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AI Podcasts

May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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Crypto Podcasts

February 14, 2025

Unichain, Succinct’s Prover Network, and Crypto’s Trust Crisis | Expansion Crossover Roundup

Bell Curve

Crypto
Infrastructure

Key Takeaways:

  • 1. ZK proofs are reshaping blockchain security, offering more efficient and scalable alternatives to traditional staking models.
  • 2. Unichain and Succinct are leading innovation, enhancing cross-chain interoperability and simplifying proof generation, which can drive broader adoption.
  • 3. Enhanced security measures, like Arbitrum’s bug bounty, are critical for maintaining trust and attracting institutional investment in the crypto ecosystem.
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February 14, 2025

An Update On The Solana Thesis | Santiago Santos

Lightspeed

Crypto
Infrastructure

Key Takeaways:

  • 1. Sustainable onboarding strategies focusing on user retention outperform short-term speculative events.
  • 2. Integrating crypto into established businesses can drive broader adoption by enhancing user experience without necessitating direct crypto engagement.
  • 3. Solana’s robust infrastructure and scalability make it a strong contender against Ethereum, presenting significant investment potential.
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February 13, 2025

Ethereum’s Future, Berachain’s Q5 Launch, and App Revenue | Analyst Round Table

0xResearch

Crypto
Infrastructure
DeFi

Key Takeaways:

  • 1. Bitcoin’s stabilization through ETFs and institutional interest may offer a reliable investment anchor amidst volatile altcoin markets.
  • 2. Ethereum’s advancements in native rollups could redefine its scalability and security, making it a pivotal player for decentralized application development.
  • 3. Emerging Layer 1 chains like Berachain must focus on timely app onboarding and sustainable tokenomics to navigate market challenges and achieve growth.
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February 13, 2025

Story Protocol Exclusive: AI Agents For Everything, On-Chain IP & Owning Your Data

blocmates.

AI
Crypto
Infrastructure

Key Takeaways:

  • 1. Story Protocol is poised to democratize the $61 trillion IP market through blockchain, significantly lowering barriers to entry and enhancing accessibility.
  • 2. Tokenized and programmable IP on Story enables efficient, transparent licensing and revenue sharing, attracting both creators and investors.
  • 3. Integration with AI agents and strategic partnerships position Story at the forefront of the AI-driven future of IP management, offering substantial investment opportunities.
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February 10, 2025

Crypto's Ultimate End State With Avery Ching

Empire

Crypto
Infrastructure

Key Takeaways:

  • 1. Aptos Leads with Superior Scalability: Demonstrates industry-leading transaction capabilities, setting a new standard for blockchain performance.
  • 2. Strategic Ecosystem Support: Comprehensive support for developers and a strong regional focus are key drivers for Aptos' growth and adoption.
  • 3. Future-Proof Architecture: Aptos’ vision for interoperability and fewer, more efficient chains highlights its commitment to sustainable blockchain infrastructure.
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February 10, 2025

Jeffrey "Jiho" Zirlin: Ronin Goes Permissionless

Delphi Digital

Crypto
Infrastructure
DeFi

Key Takeaways:

  • 1. Strategic Infrastructure Development: Building tailored blockchain solutions like Ronin is crucial for scaling successful blockchain games and attracting high-quality projects.
  • 2. Quality-Driven Ecosystem Growth: Focusing on curated partnerships ensures sustainable growth and robust economic models, setting the foundation for long-term success.
  • 3. Innovative Tokenomics: Advanced economic strategies and dynamic NFTs are essential for creating resilient and engaging play-to-earn ecosystems, driving user retention and market stability.
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