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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

June 2, 2025

Bitcoin Hits Escape Velocity! Mike Novogratz on the Bond Crisis, Genius Act & AI’s Crypto Future

Bankless

Crypto
Key Takeaways:
  1. Bitcoin's Bull Run is Just Starting: Driven by broad adoption and macro uncertainty, Bitcoin has hit "escape velocity" with significant upside potential.
  2. Regulatory Winds Have Shifted: The impending Genius Act and a more crypto-friendly SEC are set to unleash a wave of innovation and institutional participation.
  3. Tokenization & AI are Converging: The tokenization of real-world assets, especially equities, and the build-out of AI infrastructure (often by crypto-related entities) are major growth vectors.
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June 2, 2025

Finding Product Market Fit In Crypto

Lightspeed

Crypto
Key Takeaways:
  1. **Infrastructure is the New Frontier:** Prioritize crypto ventures using blockchain as a foundational layer to innovate and compete with Web2, moving beyond purely crypto-centric applications.
  2. **Solve Real Problems, Not Chase Hypotheses:** True PMF stems from addressing tangible user pain points; market creation is often a byproduct of successful problem-solving, not an initial goal.
  3. **Large Markets Fuel Pivots:** While a sharp focus is vital, building within a substantial market provides the necessary runway and adjacent opportunities critical for navigating the path to PMF.
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June 2, 2025

The Race to Replace Mainnet | Ian Unsworth, Kairos Research

0xResearch

Crypto
Key Takeaways:
  1. UX is King: Seamless, integrated user experiences (like Hyperliquid's or a desired "Robin Hood for crypto") will win, as fragmentation (EVM L2s) breeds user frustration and churn.
  2. Solana's Ascent: Alpenlow’s 150ms finality and zero voting costs significantly enhance Solana's competitive edge, driven by an "underdog" culture of relentless improvement.
  3. ETH's Identity Search: Ethereum needs decisive leadership and a unified technical/narrative strategy to counter fragmentation and challengers; price pressure often serves as its main catalyst for action.
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June 1, 2025

We Asked Flood About His Hyperliquid Bull Thesis

The Rollup

Crypto
Key Takeaways:
  1. **Hyperliquid (Hype) is King:** Flood states, "It's the only asset that matters in crypto other than Bitcoin... Nothing else makes money," citing its strong fundamentals and mispricing.
  2. **L1s are Uninvestable Commodities:** Focus on applications and frontends that directly serve users; L1s are a race to the bottom on fees and vulnerable to tech disruption.
  3. **Builder Codes Fuel an Ecosystem:** Hyperliquid's permissionless monetization will attract a wave of development, creating a moat through network effects and specialized user experiences.
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May 31, 2025

LIVE Hivemind: Crypto Treasury Companies, Sui Hack & Solana’s New Consensus

Empire

Crypto
Key Takeaways:
  1. Treasury Tactics: The "treasury company" model is the new "low float, high FDV" game, but relies on continued premium valuations and favorable debt markets; watch out for stress when debt matures.
  2. Sui's Pragmatism: Sui’s handling of the Cetus hack signals that newer chains may prioritize decisive action and recovery over decentralization purity in crises, a trend likely to continue.
  3. Solana's Evolution: Solana’s major consensus upgrade, developed by former critics, showcases a pragmatic, engineering-first approach focused on performance and validator accessibility, potentially strengthening its L1 position.
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May 31, 2025

Where Crypto Meets AI with Chris Dixon & David George

a16z

Crypto
Key Takeaways:
  1. Crypto Delivers Utility: Stablecoins move trillions monthly, proving crypto's real-world value beyond speculation for fast, cheap global payments.
  2. AI Rewrites Web Economics: AI's direct-answer capability breaks the old ad-traffic model. Crypto offers tools to build the new economic "covenant" required.
  3. Bet on Category Kings: Tech markets are "winner-take-all." Focus on the dominant player in any credible category, especially those led by founders with unique, "earned secrets."
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