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AI Podcasts

February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The AI industry is moving from a focus on raw model size to a sophisticated interplay of frontier research, efficient distillation, and specialized hardware. This means the "best" model isn't just the biggest, but the one optimized for its specific deployment context, driven by energy efficiency and latency.
  2. Prioritize investments in hardware and software architectures that enable extreme low-latency inference and multimodal processing. For builders, this means designing systems that can leverage both powerful frontier models for complex tasks and highly optimized "flash" models for ubiquitous, real-time applications.
  3. The next 6-12 months will see a continued acceleration in AI capabilities, driven by a relentless focus on making models faster, cheaper, and more context-aware. Companies that excel at distilling cutting-edge AI into deployable, low-latency solutions will capture significant market share and redefine user expectations.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The AI industry is consolidating around unified, multimodal general models, moving past the era of highly specialized, single-task AI. This means foundational models will increasingly serve as the base for all applications, with specialized knowledge integrated via retrieval or modular training.
  2. Invest in low-latency AI infrastructure and model architectures. The future of AI interaction hinges on near-instantaneous responses, enabling complex, multi-turn reasoning and agentic workflows that are currently bottlenecked by speed and cost.
  3. The race for AI dominance is a full-stack game: superior hardware, efficient model architectures, and smart deployment strategies are inseparable. Companies that master this co-evolution will capture the next wave of AI-driven productivity and user experience.
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February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. The open-source AI movement is democratizing advanced scientific tools, particularly in generative biology, forcing a re-evaluation of proprietary models' long-term impact on innovation.
  2. Builders and investors should prioritize platforms that combine cutting-edge open-source models with robust, scalable infrastructure and extensive experimental validation.
  3. The future of drug discovery will be driven by accessible, validated generative AI platforms that empower a broad scientific community, rather than relying on a few closed, black-box solutions. This means faster iteration, lower costs, and a higher probability of discovering novel therapeutics in the next 6-12 months.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. Prioritize low-latency AI interactions and invest in tools that enable precise, multimodal prompting.
  2. The relentless pursuit of AI capability is increasingly tied to the energy efficiency of data movement, driving a co-evolution of model architectures and specialized hardware.
  3. The next 6-12 months will see a significant acceleration in personalized AI experiences and a continued push for ultra-low latency models, making crisp communication with AI a competitive advantage.
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February 12, 2026

OpenClaw: The Viral AI Agent that Broke the Internet - Peter Steinberger | Lex Fridman Podcast #491

Lex Fridman

AI
Key Takeaways:
  1. The rise of autonomous AI agents is fundamentally reconfiguring the digital economy, transforming traditional software applications into agent-addressable services and democratizing building by lowering the technical bar for creation.
  2. Invest in platforms and tools that prioritize agent-friendly APIs and open-source collaboration, as these will capture the next wave of digital value creation.
  3. Personal AI agents are not just tools; they are a new operating system layer that will redefine how we interact with technology and each other. Understanding this shift is critical for navigating the next 6-12 months of rapid innovation and market disruption.
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February 11, 2026

Ep#62: PolaRiS: Scalable Real-to-Sim Evaluations for Generalist Robot Policies

RoboPapers

AI
Key Takeaways:
  1. Adopt PolaRiS for policy iteration. Builders should use its browser-based scene builder and Gaussian splatting pipeline to quickly create new, diverse evaluation environments from real-world scans.
  2. Integrate minimal, unrelated sim data into policy training to dramatically boost real-to-sim correlation, allowing for faster, cheaper development cycles before costly real-world deployment.
  3. PolaRiS shifts the focus from hand-crafted, task-specific simulations to scalable, real-world-correlated benchmarks, enabling rapid iteration and generalization testing previously impossible in robotics.
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February 12, 2026

OpenClaw: The Viral AI Agent that Broke the Internet - Peter Steinberger | Lex Fridman Podcast #491

Lex Fridman

AI
Key Takeaways:
  1. Agentic AI is changing software from discrete applications to an integrated, conversational operating layer, making human intent the primary interface for complex tasks.
  2. Invest in or build platforms that prioritize agent-friendly APIs and open-source collaboration, as these will capture the next wave of user interaction and value generation.
  3. The future of computing is agent-centric; understanding and adapting to this paradigm change is crucial for staying relevant in the quickly evolving tech landscape over the next 6-12 months.
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February 12, 2026

OpenClaw: The Viral AI Agent that Broke the Internet - Peter Steinberger | Lex Fridman Podcast #491

Lex Fridman

AI
Key Takeaways:
  1. Autonomous AI agents are shifting software from static apps to dynamic, self-adapting systems. This will redefine the app landscape, as personal agents absorb functions previously requiring dedicated software, forcing companies to become API-first.
  2. Cultivate "agent empathy" by learning to communicate effectively with AI models, understanding their context, and guiding them through complex tasks. This skill is paramount for builders leveraging AI for rapid development.
  3. Agentic AI is a new operating paradigm reshaping how we interact with technology and what it means to "build." Investors should seek projects prioritizing open-source, community-driven development and agent-native design.
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February 12, 2026

OpenClaw: The Viral AI Agent that Broke the Internet - Peter Steinberger | Lex Fridman Podcast #491

Lex Fridman

AI
Key Takeaways:
  1. The Macro Shift: AI agents are transforming software from discrete applications into an interconnected, conversational operating layer, shifting the value from app-specific functionality to intelligent orchestration and personalized user experience.
  2. The Tactical Edge: Experiment with agentic engineering by treating AI models as collaborative, context-aware engineers; focus on clear, concise prompts and iterative feedback loops to guide their development process.
  3. The Bottom Line: The future belongs to builders who understand how to design for and collaborate with AI agents, as they will unlock unprecedented efficiency and create new categories of personalized, proactive digital experiences, making traditional apps a relic of the past.
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Crypto Podcasts

May 23, 2025

Crypto's Next DePIN Catalyst With David Rhodus, Pipe Network

Lightspeed

Crypto
Key Takeaways:
  1. Performance First: Pipe's core bet is that significantly lower latency (single-digit milliseconds) via hyper-local nodes will provide a compelling performance advantage over incumbent CDNs.
  2. Work, Not Just Presence: The "proof of work" model, rewarding actual bandwidth egress (verified by ZKTCP) rather than mere uptime, aligns incentives directly with network value creation.
  3. Pragmatic Decentralization: Pipe leverages Solana for its current strengths but aims for product-market fit with Web2 clients first, seeing crypto as an enabling layer for a better, faster, and potentially cheaper CDN service, especially for underserved markets and emerging AI applications.
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May 22, 2025

The Rise of Internet Capital Markets | Analyst Round Table

0xResearch

Crypto
Key Takeaways:
  1. Internet Capital Markets Are Ascendant: New platforms are enabling rapid, token-based fundraising for early-stage ideas, blurring lines between meme coins and innovative startup capital.
  2. Mobile is Crypto's Next Major Arena: The demand for sophisticated, user-friendly mobile trading and DeFi applications presents a massive, largely untapped opportunity for developers and investors.
  3. Ethereum's Economic Model Faces Scrutiny: The discourse intensifies over whether Ethereum's L2-centric scaling roadmap, without a stronger L1 revenue focus, can sustain its valuation and market position long-term.
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May 21, 2025

The World’s First Truly Private Messaging App with Session | Kee Jefferys + Chris McCabe

Proof of Coverage Media

Crypto
Key Takeaways:
  1. True Privacy is Priceless (and Achievable): Session demonstrates that "can't be evil" isn't just a slogan; it's an architectural choice that eliminates data honeypots.
  2. Tokens Can Power Real Infrastructure: The Session token is vital for its DePIN, incentivizing a robust, decentralized network crucial for private communication.
  3. Organic Growth Signals Real Demand: Achieving 1M+ MAUs without token-based growth hacks validates a strong product-market fit for privacy-centric applications.
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May 21, 2025

Bitcoin Above $100k, Is Alt Season Here?

1000x Podcast

Crypto
Key Takeaways:
  1. Bitcoin's Rally Has Legs: Bitcoin's ascent beyond $100k is backed by robust institutional interest and a significant decoupling from equities, making $120k a tangible near-term target; however, high leverage in futures markets signals a need for short-term caution.
  2. Alt Season is Brewing: The market is shifting focus to "real businesses" within crypto, igniting a potential altcoin season. Investors should seek revenue-generating protocols with solid fundamentals and transparent operations.
  3. Product Innovation Signals Deep Demand: The explosion of diverse crypto financial products tailored for institutional investors indicates a profound, underlying demand that's only beginning to be tapped, marking a maturation of the crypto market.
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May 21, 2025

The REV Debate: Real Metric or Fake News? Jon, Bread, & Andy8052

Bankless

Crypto
Key Takeaways:
  1. REV is a starting point, not the finish line: It's a useful, objective measure of immediate user willingness to pay for blockspace but doesn't encompass all value drivers of an L1.
  2. App-layer eats L1 lunch (eventually): Expect applications to get better at internalizing value (like MEV), potentially reducing direct REV flow to L1s, making app success crucial for the L1 ecosystem.
  3. Narrative & adoption still trump pure metrics: For now, perceived momentum, user growth, and developer activity (like on Solana) can heavily influence L1 valuations, often overshadowing strict adherence to metrics like REV multiples.
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May 21, 2025

The Solana Treasury Strategy

Lightspeed

Crypto
Key Takeaways:
  1. Investing in specialized crypto treasury vehicles offers exposure not just to the underlying asset but also to a strategy of active accumulation and yield enhancement. These companies argue their NAV premiums are justified by their operational capabilities and future growth prospects.
  2. NAV Premiums Signal Future Growth: Market premiums on crypto-holding companies often reflect expectations of continued asset accumulation, not just current asset values.
  3. Expertise Drives Alpha: Specialized operational capabilities, like in-house validator management, can generate significantly higher yields (20-40% more) than readily available retail options.
  4. Sophisticated Strategies Outperform Simple Holding: For investors seeking optimized exposure, vehicles offering complex, managed strategies for asset accumulation and yield can provide an edge over direct, passive investment.
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