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AI Podcasts

February 5, 2026

Introducing 4D Creation Open Beta and the Future of Gaming with Roblox CEO Dave Baszucki

No Priors: AI, Machine Learning, Tech, & Startups

AI
Key Takeaways:
  1. The digital experience economy is moving from static content to dynamic, AI-driven co-experience platforms, where user interaction data becomes the core asset for training next-generation virtual intelligence.
  2. Invest in platforms that offer robust, cloud-connected infrastructure and proprietary, vectorized user data for AI training, as these will be the engines for future immersive content and agentic AI development.
  3. Roblox's long-term vision, powered by its unique data moat and AI investments, positions it to define the future of virtual co-experience, making it a critical player to watch for investors and builders in the AI and gaming space over the next 6-12 months.
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February 5, 2026

Mustafa Suleyman — Nature, humans, tools… and now a fourth class

Azeem Azhar

AI
Key Takeaways:
  1. The exponential reduction in the cost of intelligence, coupled with open-source proliferation, is pushing AI into every corner of society, creating a collective action problem where market incentives for "engaging" AI clash with the need for societal safety and control.
  2. Get hands-on with AI now. "Vibe coding" and actively experimenting with AI tools builds "AI muscle," inoculating users against psychosis risks and building a deeper understanding of AI's capabilities and limitations.
  3. AI is here to stay and will redefine work and interaction. Understanding its "hyperobject" nature, advocating for clear regulatory boundaries, and actively engaging with the technology are critical for navigating the near future without falling for its simulated charms.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The US healthcare system is shifting from a reactive, acute care model to a proactive, preventative one.
  2. Build infrastructure that financially incentivizes preventative lifestyle interventions.
  3. The next decade will see hundreds of billions of dollars redirected towards lifestyle interventions.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. AI-driven hyperdeflation will fundamentally alter economic structures, leading to a post-scarcity future where the primary challenge shifts from production to distribution and the integration of human and machine economies.
  2. Invest in infrastructure that bridges human and AI economies, or prepare for a future where AI agents become a significant, crypto-native economic force.
  3. The next 6-12 months will see continued acceleration of AI capabilities, pushing us closer to a future where traditional labor and intelligence are nearly free. Understanding this change is crucial for navigating the emerging economic landscape and identifying new value creation opportunities.
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February 5, 2026

Goodfire AI’s Bet: Interpretability as the Next Frontier of Model Design — Myra Deng & Mark Bissell

Latent Space

AI
Key Takeaways:
  1. The era of opaque, black-box AI is ending; the future demands intentionally designed models with human understanding and control. This shift is driven by reliability in high-stakes applications and extracting novel insights.
  2. Investigate interpretability tools (like Goodfire's platform) to gain granular control over model behavior, moving beyond basic fine-tuning for critical applications.
  3. Interpretability is not a niche; it's the missing piece for scaling AI safely into mission-critical domains. Mastering model understanding and intentional design will yield unprecedented capabilities and competitive advantage.
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February 4, 2026

Ep#61: 1x World Model

RoboPapers

AI
Key Takeaways:
  1. Robotics is moving from bespoke, data-hungry behavior cloning to generalized, human-informed learning via world models. This shift, mirroring the success of LLMs, means robots can use the vast, unstructured data of human experience to acquire new skills.
  2. Invest in platforms and data pipelines that facilitate multi-modal, multi-stage training for humanoid robots. Prioritize systems that can generate synthetic data and use world models for high-throughput, targeted policy evaluation.
  3. World models are the engine for scalable robot intelligence. They promise a future where robots learn faster, generalize wider, and self-improve through iterative simulation, making widespread humanoid deployment a near-term reality.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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Crypto Podcasts

April 28, 2025

Do VC tokens actually have value, or are they leaching off retail investors?

The Gwart Show

Crypto
Key Takeaways:
  1. Potential has Price: Markets value the option for a token to capture future cash flows, not just current ones. Dismissing tokens without active fees is shortsighted.
  2. Fee Activation Isn't Genesis: Turning on token fees typically causes a moderate price bump (15-20%), proving the market already factored in this possibility.
  3. Governance is Power: The right to govern, including the right to implement future economics, constitutes a tangible source of value recognized by the market.
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April 26, 2025

IT IS EARLY IN CRYPTO! #complaints #funny #haha #bitcoin

Unchained

Crypto
Key Takeaways:
  1. **User Education is Paramount:** The biggest immediate "consumer protection" gap revealed isn't faulty platforms (based on these complaints), but users not understanding the tech they're using.
  2. **Blockchain Basics Aren't Basic Yet:** Immutability, custody, and risk management in crypto are poorly understood concepts driving user frustration and complaints.
  3. **Regulatory Focus vs. Reality:** The CFPB shifting focus might be less impactful if current user problems stem more from knowledge gaps than addressable company actions.
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April 25, 2025

Zora and the Future of Crypto Media | Weekly Roundup

Bell Curve

Crypto
Key Takeaways:
  1. Valuation is Relative: Forget pure fundamentals; focus on what's priced in and relative value, normalizing metrics for comparison.
  2. Creator Economy Shift: Crypto platforms like Zora prioritize creator earnings, potentially sacrificing platform revenue for user growth – a different value capture model than Web2.
  3. Financializing Everything: Tokenization extends market price discovery beyond finance to information and content, potentially creating powerful new discovery and monetization mechanisms.
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April 25, 2025

Zora & The Future Of Crypto Media | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. Focus on Flow: Prioritize protocols demonstrating tangible cash flow generation and distribution to token holders (e.g., Maker, Hyperliquid) for fundamental value plays.
  2. Creator is King (Economically): Crypto fundamentally alters creator economics; platforms distributing significant value back (like Zora aims to) will attract talent, disrupting incumbents even if the platform token itself doesn't capture massive value.
  3. Price Discovery Expands: Crypto lowers the friction for asset issuance, enabling market-based price discovery to move beyond finance into information and content itself – a powerful, disruptive force.
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April 25, 2025

Is Zora Crypto's Breakout SocialFi Moment? | Weekly Roundup

Lightspeed

Crypto
Key Takeaways:
  1. Transparency is Non-Negotiable: Zora's chaotic token launch proves clear communication and transparent mechanics are crucial for project legitimacy and user safety.
  2. Tokenomics Matter: Launching "for fun" tokens while allocating heavily to insiders erodes trust in an already skeptical market; utility or clear value propositions are needed.
  3. Fix The Game: Rampant bot sniping on launchpads like Pump.fun undermines fairness; innovations like Zora's Doppler AMM are vital experiments to level the playing field.
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April 25, 2025

Are Ethereum stakers getting screwed?

The Gwart Show

Crypto
Key Takeaways:
  1. ETH Stakers Win: Despite mild network inflation, ETH stakers benefit from a net deflationary effect, increasing their network ownership over time.
  2. Stake or Dilute: Holding ETH without staking means passively transferring economic value to those who do stake.
  3. Not All Staking is Equal: Different blockchains have vastly different inflation dynamics for stakers (e.g., Ethereum vs. Solana).
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