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AI Podcasts

September 10, 2025

Karl Friston - Why Intelligence Can't Get Too Large (Goldilocks principle)

Machine Learning Street Talk

AI
Key Takeaways:
  1. Intelligence Has a Size Limit: Forget galaxy-spanning superintelligences. The physics of self-organizing systems suggest intelligence thrives at a specific scale, unable to exist when systems become too large or too small.
  2. True Agency is Self-Inference: The crucial leap to higher intelligence is not just modeling the world, but modeling yourself as a cause within it. This recursive "strange loop" is the foundation of planning and agentic behavior.
  3. Hardware is the Software: Consciousness is not an algorithm you can run on any machine. It likely requires a specific physical substrate where memory and processing are unified, making the body and brain inseparable from the mind.
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September 10, 2025

Chris Dixon on How to Build Networks, Movements, and AI-Native Products

a16z

AI
Key Takeaways:
  1. **Ride the Wave, Don't Fight It.** Exponential forces like Moore's Law and network effects will overwhelm any product tactic. Your first job is to identify the fundamental technological or social current you're riding.
  2. **Build a Tool, Then a Network.** Defensibility in consumer tech often comes from network effects, but you can’t start there. Solve a user’s problem in single-player mode first to build the critical mass needed for an unbeatable network.
  3. **Explore the Fringe.** The future is being prototyped in niche subreddits and hobbyist communities. To find the next big thing, look for small groups of hyper-enthusiastic people working on things that seem like toys today.
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September 9, 2025

Mark Cuban on the NBA, Cost Plus Drugs, and How to Fix Politics

a16z

AI
Key Takeaways:
  1. Find the "Death War." Cuban's biggest wins come from identifying industries where competitors are forced to spend billions to survive (like AI today or streaming media rights a decade ago). These moments create massive opportunities for suppliers and disruptors.
  2. Sell a Better Life, Not an Ideology. Whether in politics or business, success comes from solving people’s immediate, tangible problems. Abstract goals and ideological purity don't sell.
  3. The Real Moat is Domain Expertise + AI. The next generation of billion-dollar companies will be built by founders who can apply AI to specific, overlooked business processes, creating hyper-efficient, customized SaaS solutions.
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September 8, 2025

The Little Tech Agenda for AI

a16z

AI
Key Takeaways:
  1. Stop Regulating Ghosts. Policy should target concrete, illegal uses of AI under existing laws, not hypothetical future harms that require licensing regimes and kill startups before they can compete.
  2. Compliance is a Competitive Moat. Regulations designed for trillion-dollar companies are a death sentence for startups. A 50-state patchwork of rules would be the final nail in the coffin for a competitive AI ecosystem.
  3. Innovation Needs a Political War Chest. The pro-innovation camp has been outmaneuvered by well-organized "safetyism" advocates. Building political gravity through organized efforts like PACs is now essential to ensure America wins the AI race.
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September 5, 2025

Shakeel Hussein: Ridges Subnet 62, AI Agents Coding, Alpha to Equity, Future of Software | Ep. 61

Ventura Labs

AI
Key Takeaways:
  1. **The Agent is the Moat.** Ridges’ success with cheaper models demonstrates that the true differentiator in AI coding is the agent architecture, not just the underlying LLM. This focus on efficiency creates a sustainable business model where competitors burn cash.
  2. **Alpha-to-Equity Creates a Capital Bridge.** This model directly ties the token's value to profit-sharing equity, creating an arbitrage loop for crypto and traditional funds. It offers a powerful alternative to typical tokenomics by capturing the value of the underlying business.
  3. **The Future of Software is Supervisory.** The ultimate goal is not just a better coding autocomplete, but a tool that elevates developers and product managers to supervisors of AI engineering teams, fundamentally changing how software is created.
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September 4, 2025

The Stock Market Is The Economy Now

Forward Guidance

AI
Key Takeaways:
  1. The Market is the Economy. The old wall between Wall Street and Main Street has crumbled. The high degree of financialization means they are now a single, symbiotic entity.
  2. Your Portfolio is a Utility. The stock market is becoming a public utility for distributing national wealth, with ownership becoming nearly universal. This trend is set to accelerate.
  3. Capital is the New Labor. This system provides the foundation for an AI economy by creating a mechanism to pay people from capital returns, solving the problem of mass unemployment before it begins.
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September 4, 2025

The Day AI Solves My Puzzles Is The Day I Worry (Prof. Cristopher Moore)

Machine Learning Street Talk

AI
Key Takeaways:
  1. **Stop Confusing Hardness with Reality.** Theoretical computer science focuses on worst-case scenarios. Real-world success hinges on exploiting messy, latent structure that we can’t even formally define yet.
  2. **Intelligence is Tool-Making.** Humans aren't just powerful processors; we're tool-users who extend our cognitive workspace. AI will remain limited until it can recognize its own limitations and build the tools it needs to overcome them.
  3. **Demand Transparency Over Explainability.** For high-stakes decisions like criminal justice or medical diagnoses, proprietary black boxes are unacceptable. The right to confront your accuser extends to the algorithms that judge you.
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September 2, 2025

COVENANT :: The Holy Grail of Decentralized AI Training on Bittensor SN3 +SN39 Basilica +SN81 Grail

The Opentensor Foundation | Bittensor TAO

AI
Key Takeaways:
  1. Decentralized Training is Unlocked. The SparseLoCo optimizer makes training massive (70B+ parameter) models over the internet practical. This is Bittensor’s direct answer to the centralized AI training monopoly.
  2. The Future is Value-Added Compute. Raw decentralized compute is a commodity game. Covenant’s strategy with Basilica is to win by building unique, high-margin services on top, like verifiable inference and hardware efficiency amplification.
  3. The Full Stack is the Moat. By integrating pre-training (Templar), intelligent compute (Basilica), and post-training (Grail), Covenant is building a flywheel. This synergy creates an end-to-end pipeline that is more than the sum of its parts.
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September 2, 2025

Substack Cofounder on AI Slop Content & the Decline of Social Media

a16z

AI
Key Takeaways:
  1. **The Media War is Attention vs. Intention.** The future isn't about more content; it's a battle between algorithmically-generated "slop" designed to hijack your attention and curated culture that serves your long-term interests.
  2. **True Platform Power is Granting Freedom.** Substack's most defensible moat is counterintuitive: giving creators the power to leave. This forces the platform to innovate and earn its keep, fostering genuine loyalty over lock-in.
  3. **Creators Are the New Founders.** The unbundling of talent from media institutions mirrors VC's impact on tech. Independent creators are becoming "ambitious media founders," building new ventures on platforms that align value creation with value capture.
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Crypto Podcasts

March 18, 2025

Joe McCann on Why Bitcoin Is the King and Memecoins Are Over—For Now

Unchained

Crypto

Key Takeaways:

  • 1. While the current landscape for meme coins and certain trading strategies seems saturated, innovation and new implementations will drive the next wave of opportunities.
  • 2. Macroeconomic forces, particularly institutional deleveraging, are significant drivers of recent market fluctuations, but long-term fundamentals remain strong for Bitcoin and select altcoins like Solana.
  • 3. The convergence of AI and crypto holds immense potential, with orchestration playing a key role in unlocking value and efficiency across various applications.
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March 18, 2025

Why Solana’s Inflation Proposal Didn’t Pass | Weekly Roundup

Lightspeed

Crypto

Key Takeaways:

  • 1. Solana's governance processes are still evolving, requiring careful consideration of community sentiment and communication strategies.
  • 2. The Solana Foundation’s delegation program is a critical area for evaluation and potential restructuring to address decentralization concerns.
  • 3. Ethereum faces crucial decisions regarding its L1 and L2 strategy, with scaling the L1 being essential for long-term value capture.
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March 18, 2025

Alex Gluchowski and Sreeram Kannan on Their Collaborative Scaling Vision

The Rollup

Crypto

Key Takeaways:

  • 1. ZK technology is essential for scaling verifiability and enabling privacy, which are critical for broader blockchain adoption.
  • 2. The zkSync and EigenLayer partnership creates a synergistic combination of cryptographic and cryptoeconomic security, strengthening the ecosystem and ensuring greater resilience.
  • 3. The implementation of EigenLayer's novel slashing mechanism enhances the security and trustworthiness of decentralized services, paving the way for a more robust and reliable decentralized future.
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March 17, 2025

How Arbitrum is Pushing the Limits | Steven Goldfeder

0xResearch

Crypto

Key Takeaways:

  • 1. Timeboost could reshape the MEV landscape on Arbitrum, benefiting both regular users and the chain itself.
  • 2. Interoperability hinges on improving user experience, not just on developing complex technical solutions.
  • 3. Arbitrum’s long-term vision and commitment to ecosystem neutrality are key differentiators in the competitive L2 market.
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March 17, 2025

The State Of Crypto Lending | Membrane Labs

Empire

Crypto

Key Takeaways:

  • 1. While the crypto lending landscape has evolved since 2022, with improved risk management and new players, systemic risks remain.
  • 2. The convergence of centralized and decentralized finance creates new opportunities but also introduces novel challenges and potential vulnerabilities.
  • 3. Custodians stepping into lending services, coupled with increased regulatory clarity, could unlock significant growth in the crypto lending market.
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March 17, 2025

How Mode Network is the Ultimate Breeding Ground for the Cross Section of Crypto and AI | Explained

blocmates.

Crypto

Key Takeaways:

  • 1. Mode Network's focus on user experience, AI integration, and robust data infrastructure positions it as a promising platform for DeFi mass adoption.
  • 2. The innovative veTokenomics model aligns incentives and empowers community governance, fostering a thriving ecosystem.
  • 3. The convergence of DeFi and AI has the potential to unlock new financial opportunities and reshape the way users interact with blockchain technology.
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