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AI Podcasts

February 5, 2026

Introducing 4D Creation Open Beta and the Future of Gaming with Roblox CEO Dave Baszucki

No Priors: AI, Machine Learning, Tech, & Startups

AI
Key Takeaways:
  1. The digital experience economy is moving from static content to dynamic, AI-driven co-experience platforms, where user interaction data becomes the core asset for training next-generation virtual intelligence.
  2. Invest in platforms that offer robust, cloud-connected infrastructure and proprietary, vectorized user data for AI training, as these will be the engines for future immersive content and agentic AI development.
  3. Roblox's long-term vision, powered by its unique data moat and AI investments, positions it to define the future of virtual co-experience, making it a critical player to watch for investors and builders in the AI and gaming space over the next 6-12 months.
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February 5, 2026

Mustafa Suleyman — Nature, humans, tools… and now a fourth class

Azeem Azhar

AI
Key Takeaways:
  1. The exponential reduction in the cost of intelligence, coupled with open-source proliferation, is pushing AI into every corner of society, creating a collective action problem where market incentives for "engaging" AI clash with the need for societal safety and control.
  2. Get hands-on with AI now. "Vibe coding" and actively experimenting with AI tools builds "AI muscle," inoculating users against psychosis risks and building a deeper understanding of AI's capabilities and limitations.
  3. AI is here to stay and will redefine work and interaction. Understanding its "hyperobject" nature, advocating for clear regulatory boundaries, and actively engaging with the technology are critical for navigating the near future without falling for its simulated charms.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The US healthcare system is shifting from a reactive, acute care model to a proactive, preventative one.
  2. Build infrastructure that financially incentivizes preventative lifestyle interventions.
  3. The next decade will see hundreds of billions of dollars redirected towards lifestyle interventions.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. AI-driven hyperdeflation will fundamentally alter economic structures, leading to a post-scarcity future where the primary challenge shifts from production to distribution and the integration of human and machine economies.
  2. Invest in infrastructure that bridges human and AI economies, or prepare for a future where AI agents become a significant, crypto-native economic force.
  3. The next 6-12 months will see continued acceleration of AI capabilities, pushing us closer to a future where traditional labor and intelligence are nearly free. Understanding this change is crucial for navigating the emerging economic landscape and identifying new value creation opportunities.
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February 5, 2026

Goodfire AI’s Bet: Interpretability as the Next Frontier of Model Design — Myra Deng & Mark Bissell

Latent Space

AI
Key Takeaways:
  1. The era of opaque, black-box AI is ending; the future demands intentionally designed models with human understanding and control. This shift is driven by reliability in high-stakes applications and extracting novel insights.
  2. Investigate interpretability tools (like Goodfire's platform) to gain granular control over model behavior, moving beyond basic fine-tuning for critical applications.
  3. Interpretability is not a niche; it's the missing piece for scaling AI safely into mission-critical domains. Mastering model understanding and intentional design will yield unprecedented capabilities and competitive advantage.
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February 4, 2026

Ep#61: 1x World Model

RoboPapers

AI
Key Takeaways:
  1. Robotics is moving from bespoke, data-hungry behavior cloning to generalized, human-informed learning via world models. This shift, mirroring the success of LLMs, means robots can use the vast, unstructured data of human experience to acquire new skills.
  2. Invest in platforms and data pipelines that facilitate multi-modal, multi-stage training for humanoid robots. Prioritize systems that can generate synthetic data and use world models for high-throughput, targeted policy evaluation.
  3. World models are the engine for scalable robot intelligence. They promise a future where robots learn faster, generalize wider, and self-improve through iterative simulation, making widespread humanoid deployment a near-term reality.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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Crypto Podcasts

May 19, 2025

Logan Allen: Nockchain's Global Competition for Useful ZK Proof of Work Miners Kicks Off

Delphi Digital

Crypto
Key Takeaways:
  1. ZKPoW is a Novel Force: Nockchain's ZK Proof of Work directly builds valuable ZK proving capacity, turning mining into a productive, network-enhancing activity.
  2. Hardware Revolution Looms: The mining competition will drive innovation in ZK-specific hardware (FPGAs, ASICs for polynomial math), creating a new hardware market distinct from Bitcoin's.
  3. Intent-Driven Future: Nockchain's architecture points towards a future of composable "micro-apps" and verifiable services, where on-chain logic focuses on proof verification, potentially enabling new decentralized AI/ML applications and "computational commodities."
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May 18, 2025

Weimar America: The Inflation Spiral Has Begun

Forward Guidance

Crypto
Key Takeaways:
  1. **Fiscal Dominance is Here:** Government spending, not just Fed policy, is the primary driver of the current inflationary pressures and will likely lead to an 8% GDP deficit.
  2. **Prepare for Intervention:** Expect capital controls (like remittance taxes) and yield curve control as governments grapple with the consequences of their spending.
  3. **Store-of-Value is King:** In an environment where traditional savings (e.g., 4% on bonds) can't match 15% inflation in essential costs, assets like tech stocks and Bitcoin become non-negotiable for wealth preservation.
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May 17, 2025

The Fiscal Spiral Has No Off Switch | Weekly Roundup

Forward Guidance

Crypto
Key Takeaways:
  1. Fiscal Doom Loop: The US is locked in a fiscal spiral of growing deficits and debt that it seems unwilling or unable to escape, making dollar debasement a significant long-term risk.
  2. Macro is King: Geopolitical trends, capital flows, and policy decisions (like buybacks and potential yield curve control) are now more critical drivers of asset prices than individual company fundamentals.
  3. Bitcoin's Ascent: In a world of "Ponzi schemes," Bitcoin stands out as a rational hedge and potentially the "generational trade" against failing monetary and fiscal policies.
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May 16, 2025

The Next Phase of the Bull Market | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. **Memecoin Rebound Signals Risk-On:** The sharp recovery in memecoins highlights the market's speculative appetite; treat them as high-octane, ecosystem-specific bets.
  2. **Strategic M&A is Reshaping Access:** Companies are buying their way into regulated markets and building out institutional-grade services, with "Crypto as a Service" set to grow.
  3. **Institutional Rails Getting Stronger:** Coinbase’s S&P 500 debut and EToro’s IPO are landmark events, cementing crypto's place in mainstream finance and improving market transparency.
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May 16, 2025

Markets Are EXPLODING - Here’s Why! ETH Surge, U.S. China Deal & What’s Next

Bankless

Crypto
Key Takeaways:
  1. ETH is Back (For Now): ETH's dramatic surge signals renewed conviction, but its long-term trajectory against Bitcoin remains a key market question.
  2. Macro Drives All: The U.S.-China tariff pause and potential capital control strategies will significantly impact risk assets; Bitcoin and gold are positioned as key beneficiaries of dollar devaluation.
  3. Regulation is Turning Pro-Crypto: The SEC's pivot towards clear frameworks could finally unlock institutional adoption and the tokenization of real-world assets.
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May 15, 2025

Hivemind: ETH Pump, Solana’s Edge & the New Meme Meta

Empire

Crypto
Key Takeaways:
  1. ETH Rally = Fragile Foundation: ETH's recent pump is more a short-squeeze than broad institutional buy-in; treat with skepticism.
  2. Solana's Strategic Advantages: Solana benefits from innovation, discounted token acquisitions by strategic entities, and key infrastructure developments like asset-level KYC.
  3. Meme Meta Redux: The "Internet Capital Markets" on Solana offer high-risk, high-reward plays mirroring past speculative cycles; speed and early positioning are crucial.
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