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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

July 4, 2025

All Roads Lead To Debasement | Weekly Roundup

Forward Guidance

Crypto
Key Takeaways:
  1. All Roads Lead to Debasement: Both political parties are now committed to a policy of fiscal dominance and financial repression. The goal is to inflate away the debt, which makes holding cash and traditional bonds a losing proposition.
  2. Get Out on the Risk Frontier: The only rational response is to move capital into assets that can benefit from currency debasement and a manufactured asset boom. This means frontier tech, crypto, and other high-growth, high-risk assets.
  3. The Social Contract is Breaking: These policies will blatantly exacerbate wealth inequality, fueling populist anger. The system is no longer a free market but a manipulated game, and the backlash will define the political landscape for the next decade.
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July 4, 2025

0xResearch - Crypto Treasury Mania, Stocks Onchain, and Crypto Venture | July 3rd, 2025

0xResearch

Crypto
Key Takeaways:
  1. **The Great Bifurcation:** Capital is rotating out of altcoins and into two main buckets: Bitcoin (channeled through treasury companies) and crypto-adjacent equities (COIN, HOOD). Don't mistake isolated pumps for a broad "alt season."
  2. **Synthetics are the New Speculation:** The next wave of on-chain gambling will be on synthetic versions of real-world assets, from private company shares to public stocks, providing exposure without the complexity of ownership.
  3. **Apps Over Chains:** The most valuable real estate in crypto is no longer the base layer but the application layer. Companies that build sticky, revenue-generating products with great UX—even if they just clip fees—are winning.
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July 3, 2025

Robinhood vs. Coinbase: The Trillion Dollar Race to Build the Financial Super App

Bankless

Crypto
Key Takeaways:
  1. **Bet on a Thesis:** Coinbase is a pure-play bet on the entire global economy moving on-chain, positioning itself as the essential B2B infrastructure provider.
  2. **Follow the Money:** Robinhood is a bet on demographics, strategically positioning itself to capture the next generation's financial life and inherit trillions in the great wealth transfer.
  3. **The Next Frontier is On-Chain:** The new battleground is Layer 2. Coinbase’s established Base ecosystem will face a formidable challenge from Robinhood Chain, with tokenized stocks as the initial prize.
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July 3, 2025

Crypto Meets Cards: Shaping the Future of Commerce | Permissionless IV Fireside Chat | Bonus Episode

Empire

Crypto
Key Takeaways:
  1. **Invisible Rails are the Endgame:** The winner isn't the platform that forces users to understand blockchain, but the one that makes it invisible. Mainstream adoption will arrive when consumers use stablecoins without even knowing it, powered by seamless wallet and card integrations.
  2. **Wallets Are the New Financial Hub:** Wallets are transcending simple storage to become full-fledged financial platforms. The next wave of innovation will focus on embedding neobank-like features (direct deposits, bill pay) into non-custodial wallets.
  3. **AI Will Run on Stablecoins:** The rise of autonomous AI agents executing commercial tasks will create massive demand for a programmable, internet-native currency. Stablecoins are the clear frontrunner to become the default payment rail for this new automated economy.
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July 3, 2025

How Stablecoins Are Hijacking The Yield Curve

Forward Guidance

Crypto
Key Takeaways:
  1. Exporting US Monetary Policy. Stablecoins are extending the US financial system's reach by creating a global on-ramp to dollar assets. Demand from emerging markets now directly impacts US Treasury yields.
  2. The Repo Market is the Epicenter. The crucial arena for stablecoin reserves is shifting from T-bills to the reverse repo market. This creates a massive, structural demand for overnight lending against Treasury collateral.
  3. A Permanent Weight on the Yield Curve. This constant, inelastic demand from stablecoin issuers will act as a permanent force suppressing Treasury funding rates, creating a powerful and lasting influence on the entire US yield curve.
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July 2, 2025

Is Robinhood Unlocking Crypto’s Next Frontier?

1000x Podcast

Crypto
Key Takeaways:
  1. Robinhood is the Blueprint. Its plan to launch tokenized assets on its own future Layer-2 is the new model for financial institutions, creating a direct challenge to the supremacy of existing public blockchains.
  2. Become a Trader, Not a "Crypto Trader". The most successful investors will be those who treat crypto as one of several asset classes, moving capital opportunistically based on macro trends, political shifts, and emerging frontiers like prediction markets.
  3. Politics Will Drive Your Portfolio. While both US political parties are expected to debase the dollar through spending, they present different risks. The Republican party is seen as bullish for risk assets via deregulation, while a progressive Democratic shift could introduce bearish headwinds through redistributionist policies.
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