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AI Podcasts

May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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Crypto Podcasts

April 8, 2025

The State Of Solana With Carlos Gonzalez Campo

Lightspeed

Crypto
Key Takeaways:
  1. Apps Outearn the Chain: Solana apps are generating nearly twice the revenue ($1.84) per dollar compared to the network itself, proving strong economic viability on the platform.
  2. Fundamentals Over Price: Despite SOL's price drop, core network health indicators like stablecoin supply and DEX activity remain robust, suggesting the sell-off may be detached from on-chain reality.
  3. L1 Scaling is Priority: Solana is doubling down on enhancing the L1 directly via upgrades (like TPU feedback) and app-level innovation (off-chain elements), rejecting Ethereum's L2 path to keep liquidity unified.
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April 8, 2025

Grifters, Meme Coins & the Solana Comeback

The Rollup

Crypto
Key Takeaways:
  1. Grifters Follow the Heat: Speculative actors migrate to blockchains with the highest activity and potential returns, currently favouring Solana's meme coin ecosystem.
  2. Meme Coins Drive Cycles: Love them or hate them, meme coins are a powerful catalyst for user activity, price appreciation, and ecosystem attention, replicating patterns seen in Ethereum's growth.
  3. Underdog Narratives Fuel Growth: Facing adversity can forge strong, defiant communities (like Solana post-FTX) that focus inward and drive significant comebacks, echoing Ethereum's own path to dominance.
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April 7, 2025

How to Raise Crypto VC, Investing in DePIN, Network States, and the Electro Dollar with Anirudh Pai

Proof of Coverage Media

Crypto
Key Takeaways:
  1. Real Demand Trumps Hype: Prove long-term user need and cultivate raving fans; that’s the best pitch.
  2. DePIN Needs Web2 Polish: Solve user friction, especially payments, before reinventing complex crypto-native wheels.
  3. Bet on Abundance & Serendipity: The future hinges on cheap energy and compute ("Electro Dollar"), found through irrational exploration, not just rigid pattern-matching.
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April 7, 2025

Trump vs Markets: Who Blinks First? | Avi Felman & Jonah Van Bourg

Forward Guidance

Crypto
Key Takeaways:
  1. Buy the Fear (Strategically): Extreme volatility, record volume, and forced selling signal potential bottoms; scaling into weakness is preferred over trying to perfectly time the low.
  2. Crypto Gains Relative Strength: Bitcoin benefits from deglobalization trends and anticipated global stimulus (ex-US), potentially outperforming traditional assets in this environment.
  3. Inflation Fears Overblown, Fed Pivot Likely: The market crash itself is deflationary; expect the Fed to tolerate the pain to kill inflation, then pivot towards easing (likely starting May), further supporting risk assets eventually.
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April 7, 2025

Why Is Trump Nuking Markets? | Felix Jauvin

1000x Podcast

Crypto
Key Takeaways:
  1. Trump's Gambit: The tariff chaos might be a high-stakes strategy to isolate China, forcing allies to choose sides and share the burden of the US security umbrella.
  2. Buy the Blood (Carefully): With equities down ~20% and VIX elevated, it's time to cautiously scale into risk assets, accepting potential short-term pain to catch an eventual rebound.
  3. Bitcoin's Edge: De-globalization and reactive global stimulus position Bitcoin favorably, potentially decoupling (or at least outperforming) traditional assets in the near term.
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April 7, 2025

Hating on Crypto (With Love) | Felix Jauvin & James Christoph

0xResearch

Crypto
Key Takeaways:
  1. **Stablecoin Issuers are Cash Cows:** Companies like Circle (IPO soon) benefit massively from yield capture on reserves; regulation might even lock this in.
  2. **DeFi Degens vs. TradFi Suits:** Expect ongoing clashes as institutional capital demands simpler structures, challenging crypto's complex governance/token models.
  3. **Meme Coins Aren't Dying:** Despite drawdowns, platforms like Pump.fun show meme creation/trading has strong, persistent demand and revenue generation.
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