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AI Podcasts

February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The US healthcare system is shifting from a reactive, acute care model to a proactive, preventative one.
  2. Build infrastructure that financially incentivizes preventative lifestyle interventions.
  3. The next decade will see hundreds of billions of dollars redirected towards lifestyle interventions.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. AI-driven hyperdeflation will fundamentally alter economic structures, leading to a post-scarcity future where the primary challenge shifts from production to distribution and the integration of human and machine economies.
  2. Invest in infrastructure that bridges human and AI economies, or prepare for a future where AI agents become a significant, crypto-native economic force.
  3. The next 6-12 months will see continued acceleration of AI capabilities, pushing us closer to a future where traditional labor and intelligence are nearly free. Understanding this change is crucial for navigating the emerging economic landscape and identifying new value creation opportunities.
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February 5, 2026

Goodfire AI’s Bet: Interpretability as the Next Frontier of Model Design — Myra Deng & Mark Bissell

Latent Space

AI
Key Takeaways:
  1. The era of opaque, black-box AI is ending; the future demands intentionally designed models with human understanding and control. This shift is driven by reliability in high-stakes applications and extracting novel insights.
  2. Investigate interpretability tools (like Goodfire's platform) to gain granular control over model behavior, moving beyond basic fine-tuning for critical applications.
  3. Interpretability is not a niche; it's the missing piece for scaling AI safely into mission-critical domains. Mastering model understanding and intentional design will yield unprecedented capabilities and competitive advantage.
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February 4, 2026

Ep#61: 1x World Model

RoboPapers

AI
Key Takeaways:
  1. Robotics is moving from bespoke, data-hungry behavior cloning to generalized, human-informed learning via world models. This shift, mirroring the success of LLMs, means robots can use the vast, unstructured data of human experience to acquire new skills.
  2. Invest in platforms and data pipelines that facilitate multi-modal, multi-stage training for humanoid robots. Prioritize systems that can generate synthetic data and use world models for high-throughput, targeted policy evaluation.
  3. World models are the engine for scalable robot intelligence. They promise a future where robots learn faster, generalize wider, and self-improve through iterative simulation, making widespread humanoid deployment a near-term reality.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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Crypto Podcasts

June 23, 2025

What Happened To Joyful June?

1000x Podcast

Crypto
Key Takeaways:
  1. **Oil is Your Geopolitical Crystal Ball**: Monitor oil prices (Brent) as a leading indicator for crypto's reaction to global instability.
  2. **Brace for Bitcoin Chop, Altcoin Drop**: Expect Bitcoin to range-trade, creating headwinds for altcoins; consider defensive or short strategies for alts.
  3. **Crypto-Equities: Tread Carefully**: The boom in crypto-linked stocks and "treasury companies" signals froth. While flipping Day 1 listings might offer short-term gains, the underlying structures are high-risk. A long Coinbase (COIN) / short Circle (CRCL) pair trade is floated as a more fundamentally grounded approach.
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June 23, 2025

The Token Transparency Framework, Worldcoin, and X’s Super App | Livestream

0xResearch

Crypto
Key Takeaways:
  1. Transparency is Non-Negotiable: The industry overwhelmingly supports standardized disclosures; projects can no longer hide in ambiguity.
  2. Apps Over Chains (Mostly): The new meta for exchanges involves building user-facing applications on existing, efficient blockchains rather than launching bespoke L1s/L2s, prioritizing speed-to-market and revenue.
  3. Proof-of-Humanity is Coming: As AI blurs online reality, solutions like Worldcoin, despite debate, are gaining traction with platforms desperate to verify real users.
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June 23, 2025

Is Tether The World's Most Valuable Company?

Bankless

Crypto
Key Takeaways:
  1. Profit Powerhouse: Tether's profitability ($13.7B+ annually) fuels its independence and aggressive investment strategy, making it a financial force comparable to nations in Treasury markets.
  2. Global First, US Second (Strategically): While pursuing US compliance for USDT, Tether’s core focus remains on emerging markets where its impact (and profitability) is higher. A new US-specific stablecoin will target different, value-added use cases.
  3. Beyond Stablecoins: Tether is diversifying heavily, aiming to become a top Bitcoin miner, expanding its tokenized gold offering (with physical redemption), and investing in AI and other tech, always with an eye on distribution.
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June 23, 2025

How To Fix Crypto's Token Problem

Lightspeed

Crypto
Key Takeaways:
  1. **Brace for "Junk":** Expect a deluge of low-quality tokens funded over the past two years to hit markets in the next 12-18 months. Extreme diligence is crucial.
  2. **Equity Rises:** The growth of crypto M&A, potential IPOs, and institutional interest will increasingly value revenue-generating companies and "real things" over purely speculative tokens.
  3. **Utility Is King (Eventually):** Projects delivering genuine products, strong user adoption, and productive tokenomics will ultimately define a more robust and trustworthy crypto ecosystem.
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June 22, 2025

Yano On What The New Token Transparency Framework Looks Like

Empire

Crypto
Key Takeaways:
  1. **Standardized Scrutiny Arrives:** The Token Transparency Framework introduces a systematic, 18-criteria evaluation, offering a clear benchmark for assessing token projects beyond hype.
  2. **Rewards & Repercussions:** By first celebrating transparent projects (like Jito and Jupiter) and then planning to rate less forthcoming ones, the framework aims to incentivize industry-wide improvements in disclosure.
  3. **Investor Toolkit Boost:** This framework provides investors with a concrete tool for due diligence, moving towards a more informed and transparent crypto investment landscape.
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June 21, 2025

0xResearch | June 20th, 2025

0xResearch

Crypto
Key Takeaways:
  1. CEXs Go Lean: Exchanges are increasingly opting for lighter on-chain footprints, prioritizing app development on existing chains over building new L1s/L2s, signaling a focus shift to direct user value.
  2. Transparency is Non-Negotiable: The 0xResearch Token Transparency Framework highlights a critical industry need for standardized disclosures, aiming to build trust and attract serious capital by demystifying token projects.
  3. Utility Drives Valuation: Projects like Kamino, despite strong fundamentals and growth, underscore that clear token utility and value accrual mechanisms are essential for market recognition and valuation.
See full notes