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AI Podcasts

August 4, 2025

Dwarkesh Patel and Noah Smith on AGI and the Economy

a16z

AI
Key Takeaways:
  1. Redefine AGI from Consciousness to Commerce. Forget Turing tests. The real benchmark for AGI is its ability to automate ~95% of white-collar work. The biggest missing piece isn't reasoning, but the capacity for continuous, on-the-job learning.
  2. Prepare for an Economic Singularity. Post-AGI growth won't be an incremental bump; it will be an explosive shift to 20%+ annual growth, driven by infinitely scalable AI labor. The bottleneck won't be human demand but the ambitions of the agents controlling the AI.
  3. The AGI Race Is More Industrial Revolution than Cold War. AGI is not a single bomb but a transformative process. The key risk isn't one nation nuking another, but advanced AIs playing nations against each other, much like the East India Company did in India.
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August 4, 2025

Micaela Bazo & Pedro Penna: AI, Drug Discovery, Decentralized Science, Behavioral Medicine | Ep 55

Ventura Labs

AI
Key Takeaways:
  1. Decentralize R&D for Efficiency. Using token-incentivized networks like Bittensor radically cuts costs and accelerates the initial drug discovery phase by tapping a competitive, global talent pool.
  2. Go Upstream for Bigger Wins. Targeting root "behavioral" causes of disease instead of just symptoms creates drugs with multi-condition applications, unlocking massive, previously unseen market potential.
  3. Innovate on Existing Rails. The fastest path to impact is by building on proven systems. Focusing on small molecules and using industry-standard validation partners creates a practical bridge between the worlds of crypto and traditional pharma.
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August 1, 2025

Will Market Euphoria Cool Off In August? | Weekly Round-Up

Forward Guidance

AI
Key Takeaways:
  1. Stagflation is Here: The Fed is poised to cut rates into rising inflation, an unorthodox move that signals how boxed-in monetary policy has become.
  2. The Two-Tiered Economy is Real: Capital is flowing to the "productive frontiers" of AI and tech, while legacy industries and the un-invested class get crushed. Policy is exacerbating this divide.
  3. Be Tactical, but Bet on the Ponzi: Expect a choppy August as euphoria cools. The long-term game, however, remains the same: bet on the assets that benefit from a global flight out of failing fiat and into productive, scarce technologies.
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August 1, 2025

MCP vs Browser Agents and Moving Beyond Crypto in the AI Space

Trillion Agents

AI
Key Takeaways:
  1. Crypto Is a Niche, Not a Foundation. AI builders are actively scrubbing crypto references from their branding to close enterprise deals. The market has decided: for now, crypto’s role is a payment rail, not the core agent stack.
  2. Bet on Native Protocols, Not Browsers. Browser-based agents are a dead end. The future belongs to agent-native protocols like MCP that enable efficient, bidirectional communication, mirroring the shift from mobile web to native apps.
  3. The AI Race Is a Power Race. The real bottleneck for AGI isn't just chips; it's energy. China's massive infrastructure build-out poses a strategic challenge to the West, which is betting on innovation in nuclear to keep pace. The future of AI may be decided by who can build power plants the fastest.
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July 31, 2025

How Distributed Compute Could Solve AI's Energy Crisis, w/ the CEO of Akash

The People's AI

AI
Key Takeaways:
  1. Energy is the New Scarcity. The race for AI supremacy is a race for power. Platforms like Akash that efficiently harness distributed, underutilized energy offer the only scalable alternative to the centralized model's impending energy crisis.
  2. The Tech is Maturing Rapidly. Asynchronous training and ZK-proofs (championed by projects like Jensen) are making permissionless global compute networks a reality. The performance gap with centralized systems is closing fast.
  3. The Mainstream is Buying In. A confluence of academic acceptance (at conferences like ICML) and favorable government policy (the White House's pro-open-source stance) is creating powerful tailwinds. The narrative has shifted from if decentralized AI is possible to how it will be implemented.
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July 31, 2025

The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)

Latent Space

AI
Key Takeaways:
  1. RLVR is the New SOTA for Solvable Problems: For tasks with clear right answers (code, math), RLVR is the state-of-the-art training method. The community is focused on scaling it, while RLHF remains the domain of fuzzy, human-preference problems.
  2. The Future is Search-Driven: GPT-4o’s heavy reliance on search is not a bug; it’s a feature. The hardest problem is no longer giving models tools, but training them to learn when to use them.
  3. Agents Need More Than Skills: The next leap in AI requires training for strategy, abstraction, and calibration. The goal is an AI that doesn’t just answer questions but efficiently plans its own work without wasting compute.
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July 31, 2025

China Open-Source, Compute Arms Race, Reordering Global Trade | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. China's Open-Source Models are Winning on Price & Performance. Chinese models offer ~90% of the intelligence of top US proprietary models for a fraction of the cost, driving massive global adoption and threatening to commoditize the model layer. An American open-source champion is desperately needed to compete.
  2. The "Cost is No Object" Compute Buildout is Reshaping the Market. A handful of private companies are spending at a loss to capture market share, fueled by VC. This creates a "sport of kings" dynamic that public companies can't match and makes pick-and-shovel players like Nvidia the biggest winners.
  3. The US Tariff Strategy is Working. Contrary to consensus, the administration's tariff gambit has secured favorable trade deals with the EU and Japan, generating hundreds of billions in revenue without causing significant consumer inflation, and setting the stage for a major renegotiation with China.
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July 31, 2025

Health Tech Founders: The Future of Care Is Personalized, Proactive—and AI-Powered

a16z

AI
Key Takeaways:
  1. Biology is the ultimate API for AI. The most impactful AI will be fed not just digital data but real-world biological signals. Companies are building the infrastructure to bring a user's biology online, turning abstract health data into a constant, actionable feed.
  2. Engagement metrics are being rewritten. Forget Daily Active Users. The new model is "intense, intentional engagement" during periods of need. Growth is a function of trust and real-world impact, where the best champions are users who have been genuinely helped.
  3. AI's role is augmentation, not automation. The goal isn't to replace doctors or therapists but to empower them. By translating noise into signal, AI lets human experts skip the data-sifting and focus on what they do best: solving problems.
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July 30, 2025

AI Content and the War for Your Attention

a16z

AI
Key Takeaways:
  1. AI is an attention-polluting machine. The primary challenge for social platforms will soon be managing the tidal wave of AI-generated "slop" designed to hijack algorithms, which risks alienating users entirely.
  2. The future of social is private. The psychological burden of being a micro-celebrity in a digital panopticon is pushing users away from public feeds and into smaller, trusted, and often monetized group chats.
  3. Attention mining’s endgame is total immersion. With phones saturated, the commercial logic of adtech demands new frontiers. VR is the path to monetizing waking hours, and Neuralink is the one to monetize dreams.
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Crypto Podcasts

February 3, 2026

The Crypto Community Hangover w/ David Hoffman

The Gwart Show

Crypto
Key Takeaways:
  1. The Macro Shift: From unbridled, community-driven idealism to a pragmatic, business-focused approach. Early crypto imagined a world where "everything is a thing on Ethereum," but reality has narrowed its primary use cases to finance and trading, forcing a re-evaluation of tokenomics and community models. This shift is also driven by AI capturing mindshare and traditional finance co-opting blockchain tech.
  2. The Tactical Edge: Re-evaluate token distribution models. Instead of relying on inflationary yield farming that creates sell pressure, explore innovative approaches like Cap's "stable drop" (airdropping stablecoins, then inviting participation in a token sale) to align incentives and attract long-term holders. Focus on building real products with defensible business models, even if they lean more "business" than "protocol."
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February 2, 2026

Gavin Zaentz & Pranav Ramesh: Leadpoet, Lead Generation, Intent-Driven Sales Automation | Ep. 79

Ventura Labs

Crypto
Key Takeaways:
  1. The shift from centralized, static data aggregation to decentralized, real-time, incentivized intelligence networks is fundamentally changing how data-intensive industries operate.
  2. Investigate subnet opportunities where incumbent data quality is low and validation is a core challenge.
  3. The future of sales is not just about more leads, but smarter, fresher, and more relevant ones.
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February 3, 2026

Gold Crashes, Bitcoin Slides, and the Fed Shock Markets

Unchained

Crypto
Key Takeaways:
  1. The Macro Shift: As trust erodes in traditional financial systems and geopolitical risks rise, capital is flowing towards more efficient, permissionless DeFi markets. This is forcing traditional finance to adapt or lose market share.
  2. The Tactical Edge: Evaluate DATs trading below NAV for potential M&A or activist plays, as these discounts often reflect management misalignment rather than fundamental asset weakness.
  3. The Bottom Line: The current market volatility, Fed policy shifts, and the rise of DeFi are not just noise; they are reshaping capital allocation. Investors and builders must understand these structural changes to position for the next cycle of institutional adoption.
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February 2, 2026

Metals Crash & Bitcoin Breaks $80k

1000x Podcast

Crypto
Key Takeaways:
  1. Global economic uncertainty and tariff threats are triggering a broad risk-off sentiment, creating dislocations where fundamentally strong assets are sold indiscriminately.
  2. Reallocate capital from speculative metals positions into Bitcoin at current levels and high-conviction, revenue-producing crypto platforms like Hyperliquid.
  3. The current market turbulence is separating the signal from the noise. Focus on assets with strong fundamentals and organic usage, as they are poised for significant gains once the broader market stabilizes.
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February 3, 2026

Is BTC A Buy, Metals Crash, Hyperliquid RWAs, New Fed Chair

1000x Podcast

Crypto
Key Takeaways:
  1. Global market indigestion is creating a flight to quality and a re-evaluation of speculative assets. This environment favors fundamentally strong assets and platforms with clear utility over pure FOMO plays.
  2. Consider tax-loss harvesting Bitcoin positions that are out of the money and reallocate to high-conviction, revenue-producing crypto assets like Hyperliquid.
  3. The "crypto portfolio" concept is evolving; focus on individual assets with strong organic usage and mega-trend tailwinds. This strategic shift will differentiate winners from losers in the coming market cycles.
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February 2, 2026

Why BitGo Went Public | Mike Belshe

Empire

Crypto
Key Takeaways:
  1. Regulatory clarity and institutional demand are converging, driving a fundamental re-architecture of financial market infrastructure. This shift will see traditional finance increasingly rely on regulated crypto-native service providers.
  2. Builders and investors should prioritize infrastructure providers that offer robust regulatory compliance and fiduciary protection, as these are the non-negotiable requirements for the next wave of institutional capital.
  3. The digital asset industry is poised for massive growth, driven by Wall Street's entry. Companies like BitGo, by building transparent, regulated infrastructure, are not just participating in this growth; they are actively shaping the future of finance, making now the time to understand these foundational shifts.
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