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AI Podcasts

May 30, 2025

OpenAI, Hyperliquid, and the Internet's Next Growth Phase | Roundup

Bell Curve

AI
Key Takeaways:
  1. AI is the primary internet growth driver; crypto will largely be downstream.
  2. Hyperliquid's app-first L1 strategy and strong fee generation make it a formidable, closely-watched player.
  3. The era of "free money" airdrops is fading, replaced by "skin-in-the-game" token launches and significant institutional capital via treasury vehicles.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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Crypto Podcasts

December 15, 2025

AI Knows You Too Well: Is Privacy a Lost Cause? | Andy Yen, Founder of Proton

Bankless

Crypto
Key Takeaways:
  1. Strategic Shift: The battle for privacy is a battle for power asymmetry. Companies with transparent, privacy-aligned business models (e.g., Proton's hybrid non-profit/for-profit structure) offer a viable alternative to surveillance capitalism.
  2. Builder/Investor Note: Invest in and build open-source, privacy-preserving infrastructure and applications with strong technical guarantees. The shrinking gap between open-source and proprietary AI makes this increasingly feasible and competitive.
  3. The "So What?": Your digital identity is paramount. Switching your primary email from a Big Tech provider (like Gmail) to a privacy-focused one (like Proton Mail) is a high-impact, low-effort action to opt out of pervasive data consolidation and reclaim agency in the digital age.
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December 15, 2025

Fundamentals Are The New King of Crypto | Smac & Noah Goldberg

Empire

Crypto
Key Takeaways:
  1. Strategic Implication: Crypto is moving past its "everything is beta" phase. Expect greater dispersion in asset performance, rewarding fundamental analysis over broad market exposure.
  2. Builder/Investor Note: Focus on projects with clear paths to productivity, durable advantages, and strong, substance-backed narratives. Opportunities exist in fixing token market inefficiencies and integrating crypto into existing consumer distribution channels.
  3. The "So What?": The market demands a more sophisticated approach. Investors and builders who can identify and execute on real-world value creation, rather than relying on hype cycles, will capture the most significant returns in the next 6-12 months.
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December 14, 2025

Be Careful With Your Taxes If You Have Crypto ETFs: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Proactive Tax Planning: Engage in tax loss harvesting now, leveraging the current wash sale exemption (with economic substance).
  2. Meticulous Record Keeping: The 1099-DA will be incomplete. Investors must maintain robust personal records for all crypto activity, especially for ETPs and DeFi.
  3. Software Opportunity: The complexity creates a massive market for sophisticated crypto tax software that can aggregate data and reconcile discrepancies.
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December 14, 2025

Teng Yan: How To Capitalize on The Biggest AI Bubble Ever (...And Who's Winning Already)

The Rollup

Crypto
Key Takeaways:
  1. Compute is King (for now): The race for compute and data center capacity will intensify until the fundamental scaling laws of AI hit a wall.
  2. Agents are Coming, with Caveats: Expect significant agentic progress in 2026, but real-world, fully autonomous agents require breakthroughs in reliability and new human-computer interaction data.
  3. Privacy as a Differentiator: Decentralized AI offering true data privacy will become a critical value proposition as centralized platforms inevitably monetize user data.
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December 14, 2025

The Hidden Cost of Zero-Fee DEX's

The Gwart Show

Crypto
Key Takeaways:
  1. Strategic Shift: The Perp DEX market is maturing beyond raw volume. Sustainable competitive advantages will come from transparent economics, innovative collateral, and robust on-chain security.
  2. Builder/Investor Note: Focus on projects solving the retail onboarding problem and those building sophisticated, yield-bearing, or cross-asset collateral systems with sound liquidation mechanics.
  3. The "So What?": Expect market consolidation over the next 5 years, with a handful of dominant Perp DEXs emerging, mirroring the CeFi landscape. Innovation in core primitives, not just new markets, will define the winners.
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December 13, 2025

Why This Token Launch Is Different

The Rollup

Crypto
Key Takeaways:
  1. Community First: Prioritizing the community through token allocation and buybacks fosters a stronger, more engaged user base from the outset.
  2. Utility Over Hype: Launching with immediate, tangible utility drives genuine adoption and long-term value creation.
  3. Ecosystem Growth: Continuously expanding the ecosystem with new features and integrations ensures sustained relevance and attracts a broader audience.
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