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AI Podcasts

December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Infrastructure Shift: AI-driven kernel optimization addresses a critical bottleneck in scaling AI compute, enabling more efficient use of diverse hardware.
  2. Builder/Investor Note: Focus on solutions with robust, hardware-verified performance metrics and a clear human-in-the-loop strategy. AI is a powerful tool for automating optimization, not a magic bullet for novel algorithmic breakthroughs.
  3. The "So What?": This technology frees expert engineers from tedious optimization, allowing them to focus on higher-level research and truly innovative algorithmic design, accelerating the pace of AI development in the next 6-12 months.
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December 16, 2025

Finding The 1% of Stocks That Matter | Henry Ellenbogen Interview

Invest Like The Best

AI
Key Takeaways:
  1. Strategic Implication: The era of "free money" inflated the number of perceived compounders; a return to positive real rates demands a sharper focus on businesses demonstrating genuine financial discipline and competitive advantage.
  2. Builder/Investor Note: Seek out "Act 2" entrepreneurs and companies that can leverage AI to transform existing physical or IP-based advantages, not just create new AI products. Be prepared to buy more when market sentiment turns negative on strong businesses.
  3. The "So What?": The next 6-12 months will differentiate companies that merely adopt AI from those that strategically integrate it to build durable, uncatchable cost and distribution advantages.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. The Future of Policing is Intelligent: Integrating AI, drones, and smart cameras creates a precise, accountable, and safer policing model for both officers and communities.
  2. Invest in the "How": Builders and investors should focus on technologies that enhance certainty of capture, streamline judicial processes, and support public-private partnerships to modernize urban safety infrastructure.
  3. Safety Fuels Mobility: Eliminating crime is not just about law enforcement; it's about restoring the fundamental safety required for economic mobility and a functional society.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade's value will accrue to those building foundational AI infrastructure and the "invisible layers" that connect intelligent systems.
  2. Builder/Investor Note: Focus capital and talent on core AI models, specialized domain intelligence, and the underlying computational fabric. Superficial applications risk rapid commoditization.
  3. The So What?: This is the defining period for the architecture of global intelligence. Participation now determines future influence and relevance.
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December 16, 2025

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security

Latent Space

AI
Key Takeaways:
  1. Strategic Shift: AI security must move beyond superficial guardrails to a full-stack, offensive red-teaming approach that accounts for the expanding attack surface of AI agents and their tool access.
  2. Builder/Investor Note: Builders should prioritize integrating offensive security early in development. Investors should be wary of "security theater" and favor solutions that embrace open-source collaboration and address the entire AI application stack.
  3. The "So What?": The accelerating pace of AI development means static security solutions will quickly become obsolete. Proactive, community-driven, and full-stack security research is essential for navigating the next 6-12 months of AI evolution.
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December 16, 2025

Why Physical AI Needs a new Data Set | Rerun CEO

Weights & Biases

AI
Key Takeaways:
  1. Data Infrastructure is the Next Bottleneck: The physical AI sector's growth hinges on specialized data tooling that can handle multimodal, multi-rate, episodic data, moving beyond traditional tabular models.
  2. Builders, Prioritize Robustness: Focus on building systems that handle real-world variability and simplify data pipelines. Leverage open-source tools and consider combining imitation and reinforcement learning.
  3. The "So What?": The next 6-12 months will see significant improvements in robot robustness and the ability to perform longer, more complex tasks. This progress will be driven by better data management, making the gap between lab demos and deployable products narrower.
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December 16, 2025

Build reliable AI agents using W&B Training

Weights & Biases

AI
Key Takeaways:
  1. The democratization of RL for LLMs will accelerate the deployment of more reliable and sophisticated AI agents across industries.
  2. Builders should move beyond basic prompt engineering and RAG. RL fine-tuning, now accessible via W&B Serverless RL, is a critical next step for high-stakes agentic applications.
  3. For the next 6-12 months, expect a surge in production-grade AI agents, with open-source models increasingly closing the performance gap with proprietary alternatives through advanced fine-tuning.
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December 15, 2025

Coding Evals: From Code Snippets to Codebases – Naman Jain, Cursor

AI Engineer

AI
Key Takeaways:
  1. Dynamic Evaluation is Non-Negotiable: Static benchmarks are dead. Future AI development demands continuously updated, contamination-resistant evaluation sets.
  2. AI Needs AI to Judge AI: As models grow more sophisticated, LLM-driven "hack detectors" become essential for ensuring code quality and preventing adversarial exploitation of evaluation systems.
  3. User Experience Drives Adoption: For interactive AI coding tools, prioritize low latency and human-centric design; technical prowess alone will not guarantee real-world usage.
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December 15, 2025

Building in the Gemini Era – Kat Kampf & Ammaar Reshi, Google DeepMind

AI Engineer

AI
Key Takeaways:
  1. Strategic Implication: The value in software development shifts from manual coding to high-level architectural design and prompt engineering.
  2. Builder/Investor Note: Experiment with AI Studio's agentic and design capabilities. Focus on describing desired functionality rather than low-level code.
  3. The "So What?": The next 6-12 months will see a surge in AI-powered, full-stack applications built by a broader range of creators, disrupting traditional development paradigms.
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Crypto Podcasts

April 23, 2025

Are there too many tokens?

The Gwart Show

Crypto
Key Takeaways:
  1. Token quantity isn't the crisis: The market has always had more tokens than it can handle; this hasn't fundamentally changed.
  2. Macro calls the shots: Current market weakness and flight-to-quality (Bitcoin > Alts) are overwhelmingly driven by global economic downturn fears.
  3. Don't misinterpret signals: Resist attributing broad market moves solely to internal crypto factors like token supply when obvious external pressures exist.
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April 23, 2025

Why a Trump vs. Fed Showdown Would Crush the U.S. Dollar - Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. **Dollar Under Fire:** Expect continued US Dollar weakness (DXY potentially heading to 70) as policy uncertainty pushes investors towards alternatives.
  2. **Rotate, Rotate, Rotate:** US large-cap equities face headwinds; scarce assets like Gold, Copper, and notably Bitcoin are the favoured plays in this stagflationary environment.
  3. **Bitcoin: Digital Gold Rising:** Bitcoin's narrative as a non-sovereign store of value and hedge against institutional instability is gaining significant traction, potentially attracting sovereign buyers soon.
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April 22, 2025

How Does Circle Compete Against Other Stablecoins?

Empire

Crypto
Key Takeaways:
  1. Margin Compression is Real: High distribution payouts ($900M to Coinbase) severely impact profitability.
  2. Banks Are Coming: Impending regulation could unleash bank competition, challenging Circle's market share.
  3. Pivot or Perish: Circle must transition from interest-rate reliance towards transaction fees or B2B partnerships to survive and justify its valuation.
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April 22, 2025

A New Era For Crypto In 2025 | Miller Whitehouse-Levine

Lightspeed

Crypto
Key Takeaways:
  1. Legislation is Coming: Expect significant movement on stablecoin and market structure bills; their final form will shape the US crypto landscape for years.
  2. Advocacy Pays (and Diversifies): The era of a single unified crypto lobby is evolving; expect more ecosystem-specific efforts alongside broader industry initiatives. Solana is planting its flag.
  3. Watch the DOJ: Beyond the SEC/CFTC, the DOJ's stance on money transmission laws (18 USC 1960) presents a serious, potentially criminal, risk that needs urgent legislative clarification.
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April 22, 2025

Market and Tariff Predictions

The Rollup

Crypto
Key Takeaways:
  1. Expect Intervention: Bond volatility at critical levels (Move Index 135) signals central banks are likely nearing intervention, potentially through rate cuts or liquidity injections.
  2. Tariffs as Catalyst: View recent tariffs as an accelerant, forcing the inevitable recourse to money printing to address systemic issues sooner.
  3. Money Printer Goes Brrr: The core conviction remains: authorities will choose monetary stimulus over austerity, ultimately boosting inflation hedges like crypto.
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April 21, 2025

Are Fundamentals Finally Bullish?

1000x Podcast

Crypto
Key Takeaways:
  1. Bitcoin's Hedging Potential is Real: Its decoupling from equities isn't just noise; it could signal a structural shift attracting significant institutional flows seeking portfolio protection.
  2. Altcoins Aren't Dead, Just Different: Forget meme coins; focus shifts to projects with tangible revenue and strong tokenomics (think exchanges like Hyperliquid with fee buybacks). Deep research is non-negotiable.
  3. Consider BTC Upside Exposure: Given the potential for a rapid, institution-led rally and relatively low implied volatility, Bitcoin call options or proxies like IBIT calls offer asymmetric upside.
See full notes