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AI Podcasts

August 4, 2025

Dwarkesh Patel and Noah Smith on AGI and the Economy

a16z

AI
Key Takeaways:
  1. Redefine AGI from Consciousness to Commerce. Forget Turing tests. The real benchmark for AGI is its ability to automate ~95% of white-collar work. The biggest missing piece isn't reasoning, but the capacity for continuous, on-the-job learning.
  2. Prepare for an Economic Singularity. Post-AGI growth won't be an incremental bump; it will be an explosive shift to 20%+ annual growth, driven by infinitely scalable AI labor. The bottleneck won't be human demand but the ambitions of the agents controlling the AI.
  3. The AGI Race Is More Industrial Revolution than Cold War. AGI is not a single bomb but a transformative process. The key risk isn't one nation nuking another, but advanced AIs playing nations against each other, much like the East India Company did in India.
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August 4, 2025

Micaela Bazo & Pedro Penna: AI, Drug Discovery, Decentralized Science, Behavioral Medicine | Ep 55

Ventura Labs

AI
Key Takeaways:
  1. Decentralize R&D for Efficiency. Using token-incentivized networks like Bittensor radically cuts costs and accelerates the initial drug discovery phase by tapping a competitive, global talent pool.
  2. Go Upstream for Bigger Wins. Targeting root "behavioral" causes of disease instead of just symptoms creates drugs with multi-condition applications, unlocking massive, previously unseen market potential.
  3. Innovate on Existing Rails. The fastest path to impact is by building on proven systems. Focusing on small molecules and using industry-standard validation partners creates a practical bridge between the worlds of crypto and traditional pharma.
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August 1, 2025

Will Market Euphoria Cool Off In August? | Weekly Round-Up

Forward Guidance

AI
Key Takeaways:
  1. Stagflation is Here: The Fed is poised to cut rates into rising inflation, an unorthodox move that signals how boxed-in monetary policy has become.
  2. The Two-Tiered Economy is Real: Capital is flowing to the "productive frontiers" of AI and tech, while legacy industries and the un-invested class get crushed. Policy is exacerbating this divide.
  3. Be Tactical, but Bet on the Ponzi: Expect a choppy August as euphoria cools. The long-term game, however, remains the same: bet on the assets that benefit from a global flight out of failing fiat and into productive, scarce technologies.
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August 1, 2025

MCP vs Browser Agents and Moving Beyond Crypto in the AI Space

Trillion Agents

AI
Key Takeaways:
  1. Crypto Is a Niche, Not a Foundation. AI builders are actively scrubbing crypto references from their branding to close enterprise deals. The market has decided: for now, crypto’s role is a payment rail, not the core agent stack.
  2. Bet on Native Protocols, Not Browsers. Browser-based agents are a dead end. The future belongs to agent-native protocols like MCP that enable efficient, bidirectional communication, mirroring the shift from mobile web to native apps.
  3. The AI Race Is a Power Race. The real bottleneck for AGI isn't just chips; it's energy. China's massive infrastructure build-out poses a strategic challenge to the West, which is betting on innovation in nuclear to keep pace. The future of AI may be decided by who can build power plants the fastest.
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July 31, 2025

How Distributed Compute Could Solve AI's Energy Crisis, w/ the CEO of Akash

The People's AI

AI
Key Takeaways:
  1. Energy is the New Scarcity. The race for AI supremacy is a race for power. Platforms like Akash that efficiently harness distributed, underutilized energy offer the only scalable alternative to the centralized model's impending energy crisis.
  2. The Tech is Maturing Rapidly. Asynchronous training and ZK-proofs (championed by projects like Jensen) are making permissionless global compute networks a reality. The performance gap with centralized systems is closing fast.
  3. The Mainstream is Buying In. A confluence of academic acceptance (at conferences like ICML) and favorable government policy (the White House's pro-open-source stance) is creating powerful tailwinds. The narrative has shifted from if decentralized AI is possible to how it will be implemented.
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July 31, 2025

The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)

Latent Space

AI
Key Takeaways:
  1. RLVR is the New SOTA for Solvable Problems: For tasks with clear right answers (code, math), RLVR is the state-of-the-art training method. The community is focused on scaling it, while RLHF remains the domain of fuzzy, human-preference problems.
  2. The Future is Search-Driven: GPT-4o’s heavy reliance on search is not a bug; it’s a feature. The hardest problem is no longer giving models tools, but training them to learn when to use them.
  3. Agents Need More Than Skills: The next leap in AI requires training for strategy, abstraction, and calibration. The goal is an AI that doesn’t just answer questions but efficiently plans its own work without wasting compute.
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July 31, 2025

China Open-Source, Compute Arms Race, Reordering Global Trade | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. China's Open-Source Models are Winning on Price & Performance. Chinese models offer ~90% of the intelligence of top US proprietary models for a fraction of the cost, driving massive global adoption and threatening to commoditize the model layer. An American open-source champion is desperately needed to compete.
  2. The "Cost is No Object" Compute Buildout is Reshaping the Market. A handful of private companies are spending at a loss to capture market share, fueled by VC. This creates a "sport of kings" dynamic that public companies can't match and makes pick-and-shovel players like Nvidia the biggest winners.
  3. The US Tariff Strategy is Working. Contrary to consensus, the administration's tariff gambit has secured favorable trade deals with the EU and Japan, generating hundreds of billions in revenue without causing significant consumer inflation, and setting the stage for a major renegotiation with China.
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July 31, 2025

Health Tech Founders: The Future of Care Is Personalized, Proactive—and AI-Powered

a16z

AI
Key Takeaways:
  1. Biology is the ultimate API for AI. The most impactful AI will be fed not just digital data but real-world biological signals. Companies are building the infrastructure to bring a user's biology online, turning abstract health data into a constant, actionable feed.
  2. Engagement metrics are being rewritten. Forget Daily Active Users. The new model is "intense, intentional engagement" during periods of need. Growth is a function of trust and real-world impact, where the best champions are users who have been genuinely helped.
  3. AI's role is augmentation, not automation. The goal isn't to replace doctors or therapists but to empower them. By translating noise into signal, AI lets human experts skip the data-sifting and focus on what they do best: solving problems.
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July 30, 2025

AI Content and the War for Your Attention

a16z

AI
Key Takeaways:
  1. AI is an attention-polluting machine. The primary challenge for social platforms will soon be managing the tidal wave of AI-generated "slop" designed to hijack algorithms, which risks alienating users entirely.
  2. The future of social is private. The psychological burden of being a micro-celebrity in a digital panopticon is pushing users away from public feeds and into smaller, trusted, and often monetized group chats.
  3. Attention mining’s endgame is total immersion. With phones saturated, the commercial logic of adtech demands new frontiers. VR is the path to monetizing waking hours, and Neuralink is the one to monetize dreams.
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Crypto Podcasts

July 29, 2025

Has ETH/BTC Bottomed?

1000x Podcast

Crypto
Key Takeaways:
  1. Price Action Is the Best Marketing. ETH’s bullish chart has single-handedly revived interest, breaking a long-term downtrend against BTC and forcing even skeptics to reconsider. The technicals are now undeniably strong.
  2. ETH Is Wall Street’s High-Beta Darling. New institutional money, looking for 5-10x returns and limited to what’s available in brokerage accounts, is flowing into ETH as the logical next step down the risk curve from Bitcoin.
  3. Trade Your Conviction. Don't chase a rally you don't understand. Entering a trade based on technicals without a fundamental framework is a recipe for selling the lows when volatility hits. For some, leveraged Bitcoin remains a more coherent trade.
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July 29, 2025

Why Charles Hoskinson Is Still Actively Involved In Crypto

Empire

Crypto
Key Takeaways:
  1. Crypto as a Political Countermeasure: For Hoskinson, blockchain is the practical tool to enforce the sound money and transparent governance that the US government has abandoned.
  2. The Federal Reserve Is a Core Target: He identifies the Federal Reserve's unchecked power over the monetary supply as a central flaw in the current system, positioning decentralized currencies as a direct challenge to its authority.
  3. A Mission, Not a Job: His daily engagement isn't for financial gain but is driven by the conviction that the fight for a more honest and accountable system is far from over.
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July 29, 2025

The State Of Solana With Carlos Gonzalez Campo

Lightspeed

Crypto
Key Takeaways:
  1. Tech Over Hype: Solana’s long-term bet is on fundamental technology. Upgrades like Jito’s BAM are designed to create a superior on-chain environment for sophisticated finance, even if it means losing short-term narrative battles to ETH.
  2. The Institutional Gap: Ethereum is currently winning the institutional game with simple, powerful stories around stablecoins and treasury assets. Solana needs a clearer, more accessible pitch beyond raw performance to compete for this capital.
  3. Performance is Non-Negotiable: The Solana ecosystem is doubling down on its high-throughput thesis. Expect a continued push for more blockspace and faster finality, even if it makes running a validator more exclusive. The trade-off is deemed worth it to bring global-scale finance on-chain.
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July 28, 2025

The Rise Of Crypto Treasury Companies

1000x Podcast

Crypto
Key Takeaways:
  1. **Treasury Companies Are A Double-Edged Sword.** They are creating massive buy-side pressure now but pose a systemic risk. Their weak debt covenants could turn a market dip into a liquidation cascade.
  2. **Market Structure Over Fundamentals (For Now).** ETH’s surge exemplifies this trend. Despite weak fundamentals, its powerful technical breakout and role as the next asset for treasury buyers are driving its outperformance.
  3. **Watch the NAV Premium.** The key health metric is the premium-to-NAV on these treasury companies. As long as investors pay $2 for $1 of crypto, the mania continues. A flip to a discount is the canary in the coal mine.
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July 28, 2025

Charles Hoskinson: ADA Is A Better Investment Than BTC

Empire

Crypto
Key Takeaways:
  1. The Cycle is Dead, Long Live the Cycle: The old four-year, retail-driven crypto cycle is over. We're in an institutionally-led "gigachad bull run" that will last through 2026 and push the market cap above $10 trillion, pending regulatory clarity.
  2. Narrative is the Ultimate Metric: Chains that focus on philosophical purity and solving real-world problems (Bitcoin, Cardano) build more resilient communities and long-term value than those chasing fleeting metrics like TPS and TVL.
  3. Bitcoin's Next Chapter will be Written on Cardano: As Bitcoin matures into a yield-bearing asset, its massive capital base will seek returns elsewhere. Cardano’s UTXO model and upcoming interoperability features are designed to capture this flow, positioning it as Bitcoin’s de facto yield layer.
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July 27, 2025

Liberation Day Broke The Dollar

Forward Guidance

Crypto
Key Takeaways:
  1. The Dollar's "Gold Moment" is Here. The dollar is decoupling from its traditional anchor (rate differentials) just as gold decoupled from real yields, signaling a permanent regime shift driven by geopolitics, not just economics.
  2. The "Dollar Smile" Has Inverted. The dollar is no longer a reliable risk-off hedge. Its positive correlation with equities means it now falls during market stress—a fundamental rewiring for asset allocators.
  3. The Devaluation Trade is a Trap (For Now). While the long-term bearish case for the dollar is clear, the trade is dangerously crowded. Expect markets to test this one-sided positioning with a painful bounce before the ultimate decline resumes.
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