Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
The Interface is the Bottleneck. Today's chatbots are the MS-DOS of AI. The next trillion dollars of value will be unlocked not by the models themselves, but by the new "Windows/Mac OS" interface that makes AI accessible and useful for everyone.
Every Creator Will Build Software. The distinction between a content creator and a software developer is collapsing. The next platforms will empower anyone to build mini-apps, turning software into a new medium for community, expression, and monetization.
Ditch the Voice-Only Dream. The Her-inspired fantasy of a screenless, voice-only AI future is a dead end. The winning AI device will be screen-first, built around an AI-native OS that makes software deeply personal and context-aware.
Culture is the Newest Yield-Bearing Asset: Arya Protocol proves that intellectual property, from music royalties to digital art, can be tokenized into stable, income-generating investments, moving beyond crypto’s speculative roots.
Fintech's Crypto FOMO is Reshaping Finance: The race is on. Traditional payment giants are rapidly adopting stablecoins, not as a gimmick, but as a critical infrastructure upgrade for building faster, cheaper, and more inclusive global financial products.
Money is Becoming Natively Programmable for AI: The future of commerce and finance will be run by AI agents. Stablecoins provide the missing piece—a programmable, automated payment layer that bypasses the friction of traditional banking, unleashing a new wave of economic activity.
Crypto as a Political Countermeasure: For Hoskinson, blockchain is the practical tool to enforce the sound money and transparent governance that the US government has abandoned.
The Federal Reserve Is a Core Target: He identifies the Federal Reserve's unchecked power over the monetary supply as a central flaw in the current system, positioning decentralized currencies as a direct challenge to its authority.
A Mission, Not a Job: His daily engagement isn't for financial gain but is driven by the conviction that the fight for a more honest and accountable system is far from over.
Tech Over Hype: Solana’s long-term bet is on fundamental technology. Upgrades like Jito’s BAM are designed to create a superior on-chain environment for sophisticated finance, even if it means losing short-term narrative battles to ETH.
The Institutional Gap: Ethereum is currently winning the institutional game with simple, powerful stories around stablecoins and treasury assets. Solana needs a clearer, more accessible pitch beyond raw performance to compete for this capital.
Performance is Non-Negotiable: The Solana ecosystem is doubling down on its high-throughput thesis. Expect a continued push for more blockspace and faster finality, even if it makes running a validator more exclusive. The trade-off is deemed worth it to bring global-scale finance on-chain.
**Treasury Companies Are A Double-Edged Sword.** They are creating massive buy-side pressure now but pose a systemic risk. Their weak debt covenants could turn a market dip into a liquidation cascade.
**Market Structure Over Fundamentals (For Now).** ETH’s surge exemplifies this trend. Despite weak fundamentals, its powerful technical breakout and role as the next asset for treasury buyers are driving its outperformance.
**Watch the NAV Premium.** The key health metric is the premium-to-NAV on these treasury companies. As long as investors pay $2 for $1 of crypto, the mania continues. A flip to a discount is the canary in the coal mine.
The Cycle is Dead, Long Live the Cycle: The old four-year, retail-driven crypto cycle is over. We're in an institutionally-led "gigachad bull run" that will last through 2026 and push the market cap above $10 trillion, pending regulatory clarity.
Narrative is the Ultimate Metric: Chains that focus on philosophical purity and solving real-world problems (Bitcoin, Cardano) build more resilient communities and long-term value than those chasing fleeting metrics like TPS and TVL.
Bitcoin's Next Chapter will be Written on Cardano: As Bitcoin matures into a yield-bearing asset, its massive capital base will seek returns elsewhere. Cardano’s UTXO model and upcoming interoperability features are designed to capture this flow, positioning it as Bitcoin’s de facto yield layer.
The Dollar's "Gold Moment" is Here. The dollar is decoupling from its traditional anchor (rate differentials) just as gold decoupled from real yields, signaling a permanent regime shift driven by geopolitics, not just economics.
The "Dollar Smile" Has Inverted. The dollar is no longer a reliable risk-off hedge. Its positive correlation with equities means it now falls during market stress—a fundamental rewiring for asset allocators.
The Devaluation Trade is a Trap (For Now). While the long-term bearish case for the dollar is clear, the trade is dangerously crowded. Expect markets to test this one-sided positioning with a painful bounce before the ultimate decline resumes.
**The Real Cycle Indicator:** Forget price targets. The bull market's health is directly tied to the premium-to-NAV on crypto treasury vehicles. When those premiums collapse, the party is over.
**L1s Are Dead Money:** The dominant thesis is a massive market re-rating where capital flees overvalued L1 infrastructure and concentrates into Bitcoin and a handful of cash-flow-positive applications.
**Stablecoins Aren't a Commodity:** The moats are deep. New issuers will struggle to compete with Tether's liquidity network effects and Ethena's structural yield advantage, making it a bear market for new stablecoin startups.
