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AI Podcasts

August 5, 2025

The New Era Of Distribution with Ram Kumar & Eowyn Chen

The Rollup

AI
Key Takeaways:
  1. A new economic model is emerging where AI and crypto converge, transforming how value is created and distributed.
  2. AI Is Becoming Specialized, Not Generalized. Forget one-size-fits-all AI. The future is in niche, fine-tuned models trained on proprietary data for specific tasks like DeFi optimization and on-chain security, making generic models like ChatGPT look like a blunt instrument.
  3. Your Wallet Is Your Paycheck. Crypto wallets are becoming the interface for a new data economy. Users will transition from being unpaid data sources to active contributors who get rewarded with tokens for training specialized AI models.
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August 4, 2025

Dwarkesh Patel and Noah Smith on AGI and the Economy

a16z

AI
Key Takeaways:
  1. Redefine AGI from Consciousness to Commerce. Forget Turing tests. The real benchmark for AGI is its ability to automate ~95% of white-collar work. The biggest missing piece isn't reasoning, but the capacity for continuous, on-the-job learning.
  2. Prepare for an Economic Singularity. Post-AGI growth won't be an incremental bump; it will be an explosive shift to 20%+ annual growth, driven by infinitely scalable AI labor. The bottleneck won't be human demand but the ambitions of the agents controlling the AI.
  3. The AGI Race Is More Industrial Revolution than Cold War. AGI is not a single bomb but a transformative process. The key risk isn't one nation nuking another, but advanced AIs playing nations against each other, much like the East India Company did in India.
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August 4, 2025

Micaela Bazo & Pedro Penna: AI, Drug Discovery, Decentralized Science, Behavioral Medicine | Ep 55

Ventura Labs

AI
Key Takeaways:
  1. Decentralize R&D for Efficiency. Using token-incentivized networks like Bittensor radically cuts costs and accelerates the initial drug discovery phase by tapping a competitive, global talent pool.
  2. Go Upstream for Bigger Wins. Targeting root "behavioral" causes of disease instead of just symptoms creates drugs with multi-condition applications, unlocking massive, previously unseen market potential.
  3. Innovate on Existing Rails. The fastest path to impact is by building on proven systems. Focusing on small molecules and using industry-standard validation partners creates a practical bridge between the worlds of crypto and traditional pharma.
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August 1, 2025

Will Market Euphoria Cool Off In August? | Weekly Round-Up

Forward Guidance

AI
Key Takeaways:
  1. Stagflation is Here: The Fed is poised to cut rates into rising inflation, an unorthodox move that signals how boxed-in monetary policy has become.
  2. The Two-Tiered Economy is Real: Capital is flowing to the "productive frontiers" of AI and tech, while legacy industries and the un-invested class get crushed. Policy is exacerbating this divide.
  3. Be Tactical, but Bet on the Ponzi: Expect a choppy August as euphoria cools. The long-term game, however, remains the same: bet on the assets that benefit from a global flight out of failing fiat and into productive, scarce technologies.
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August 1, 2025

MCP vs Browser Agents and Moving Beyond Crypto in the AI Space

Trillion Agents

AI
Key Takeaways:
  1. Crypto Is a Niche, Not a Foundation. AI builders are actively scrubbing crypto references from their branding to close enterprise deals. The market has decided: for now, crypto’s role is a payment rail, not the core agent stack.
  2. Bet on Native Protocols, Not Browsers. Browser-based agents are a dead end. The future belongs to agent-native protocols like MCP that enable efficient, bidirectional communication, mirroring the shift from mobile web to native apps.
  3. The AI Race Is a Power Race. The real bottleneck for AGI isn't just chips; it's energy. China's massive infrastructure build-out poses a strategic challenge to the West, which is betting on innovation in nuclear to keep pace. The future of AI may be decided by who can build power plants the fastest.
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July 31, 2025

How Distributed Compute Could Solve AI's Energy Crisis, w/ the CEO of Akash

The People's AI

AI
Key Takeaways:
  1. Energy is the New Scarcity. The race for AI supremacy is a race for power. Platforms like Akash that efficiently harness distributed, underutilized energy offer the only scalable alternative to the centralized model's impending energy crisis.
  2. The Tech is Maturing Rapidly. Asynchronous training and ZK-proofs (championed by projects like Jensen) are making permissionless global compute networks a reality. The performance gap with centralized systems is closing fast.
  3. The Mainstream is Buying In. A confluence of academic acceptance (at conferences like ICML) and favorable government policy (the White House's pro-open-source stance) is creating powerful tailwinds. The narrative has shifted from if decentralized AI is possible to how it will be implemented.
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July 31, 2025

The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)

Latent Space

AI
Key Takeaways:
  1. RLVR is the New SOTA for Solvable Problems: For tasks with clear right answers (code, math), RLVR is the state-of-the-art training method. The community is focused on scaling it, while RLHF remains the domain of fuzzy, human-preference problems.
  2. The Future is Search-Driven: GPT-4o’s heavy reliance on search is not a bug; it’s a feature. The hardest problem is no longer giving models tools, but training them to learn when to use them.
  3. Agents Need More Than Skills: The next leap in AI requires training for strategy, abstraction, and calibration. The goal is an AI that doesn’t just answer questions but efficiently plans its own work without wasting compute.
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July 31, 2025

China Open-Source, Compute Arms Race, Reordering Global Trade | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. China's Open-Source Models are Winning on Price & Performance. Chinese models offer ~90% of the intelligence of top US proprietary models for a fraction of the cost, driving massive global adoption and threatening to commoditize the model layer. An American open-source champion is desperately needed to compete.
  2. The "Cost is No Object" Compute Buildout is Reshaping the Market. A handful of private companies are spending at a loss to capture market share, fueled by VC. This creates a "sport of kings" dynamic that public companies can't match and makes pick-and-shovel players like Nvidia the biggest winners.
  3. The US Tariff Strategy is Working. Contrary to consensus, the administration's tariff gambit has secured favorable trade deals with the EU and Japan, generating hundreds of billions in revenue without causing significant consumer inflation, and setting the stage for a major renegotiation with China.
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July 31, 2025

Health Tech Founders: The Future of Care Is Personalized, Proactive—and AI-Powered

a16z

AI
Key Takeaways:
  1. Biology is the ultimate API for AI. The most impactful AI will be fed not just digital data but real-world biological signals. Companies are building the infrastructure to bring a user's biology online, turning abstract health data into a constant, actionable feed.
  2. Engagement metrics are being rewritten. Forget Daily Active Users. The new model is "intense, intentional engagement" during periods of need. Growth is a function of trust and real-world impact, where the best champions are users who have been genuinely helped.
  3. AI's role is augmentation, not automation. The goal isn't to replace doctors or therapists but to empower them. By translating noise into signal, AI lets human experts skip the data-sifting and focus on what they do best: solving problems.
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Crypto Podcasts

May 14, 2025

The Mistakes Crypto Is Repeating from the Tech Boom

blocmates.

Crypto
Key Takeaways:
  1. **Brace for Impact (and M&A):** Expect valuation haircuts and a rise in crypto M&A as funding tightens and runways shorten.
  2. **Prioritize Survival:** Projects that, like Vertex, obsess over downside protection are better positioned than those fueled by pure optimism.
  3. **Infrastructure Smarts:** Innovative platforms like Sonic, simplifying app-chain deployment and revenue sharing, represent a key evolution in building sustainable on-chain applications.
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May 14, 2025

Bits + Bips: Expectations for the U.S.-China Tariff Pause

Unchained

Crypto
Key Takeaways:
  1. **Tariff Truce ≠ Lasting Peace:** The 90-day U.S.-China tariff pause offers temporary market relief, but deep-seated economic tensions and China's strategic pivot to "Made by China" suggest a protracted decoupling.
  2. **Bitcoin Shines Amidst Chaos:** Bitcoin has demonstrated resilience, outperforming traditional assets during recent market turbulence and policy uncertainty, strengthening its case as a macro hedge.
  3. **Crypto Legislation Stalls, Stakes Rise:** Delayed U.S. crypto laws create uncertainty; while Bitcoin may benefit from ambiguity, broader adoption and Ethereum's institutional ambitions hinge on clearer regulatory frameworks.
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May 13, 2025

Launchpad Wars, Market Reversal, Trump Tariff Pause, and The State of AI | EP 75

Good Game Podcast

Crypto
Key Takeaways:
  1. Crypto Reimagined: Crypto is evolving into a potent funding engine for real-world innovation across sectors like research and robotics.
  2. AI's Deep Integration: AI is embedding itself into daily life, from AI shopping agents to personalized education, demanding adaptation.
  3. Strategic Agility is King: Startups must rapidly adopt new models like tokenized fundraising and AI integration to thrive in this dynamic landscape.
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May 13, 2025

Bits + Bips LIVE: US-China Tariff Deal Reignite Markets

Unchained

Crypto
Key Takeaways:
  1. Tariff Truce is Tactical: The 90-day US-China tariff pause offers temporary relief, but the underlying trade war isn't over; expect continued market sensitivity to policy shifts.
  2. Bitcoin's Macro Moment: Bitcoin's strong performance amidst geopolitical and economic uncertainty solidifies its narrative as a non-sovereign store of value and a crucial portfolio diversifier.
  3. Crypto Regs on Horizon: Despite DC's legislative snags, the potent combination of crypto industry lobbying and perceived national benefits (like stablecoins aiding deficit financing) makes eventual regulation highly probable.
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May 12, 2025

Apps Are Taking Over Crypto | 6th Man Ventures

0xResearch

Crypto
Key Takeaways:
  1. Apps Over Infra: The investment pendulum is swinging decisively towards applications that can onboard millions and generate real revenue, marking a shift from the "fat protocol" to the "fat app" era.
  2. Ecosystems are King: Choice of blockchain (Solana, Base leading for consumer) is critical; building on unproven chains is a gamble few startups can afford. Expect consolidation.
  3. Revenue & Vision Rule: Success stories like Pump.fun highlight that agile teams with a broad vision beyond niche crypto use cases (and real revenue) will capture significant market share.
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May 12, 2025

How To Build The Most Performant L1

Lightspeed

Crypto
Key Takeaways:
  1. Performance First, Decentralization Follows: L1s that prioritize and achieve superior performance will attract the most activity, leading to higher revenues and, consequently, a greater number of incentivized, decentralized validators.
  2. Profit Over Philanthropy: Forget "running a node for the cause"; long-term decentralization hinges on validators earning more than they spend. Net income is king.
  3. Solana's Uncapped Potential: Solana's design aims to break the mold by enabling an ever-increasing number of validators without sacrificing its high-speed performance, offering a path to maximal decentralization.
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