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AI Podcasts

May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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Crypto Podcasts

August 22, 2025

Making $5M in Unconventional Trades w/ 0xLaw

Taiki Maeda

Crypto
Key Takeaways:
  1. **Stop Gambling, Start Engineering.** The biggest edge isn’t in predicting price but in finding and exploiting structural market inefficiencies. Focus on trades where you can control or heavily influence the outcome, like RFV plays or creating self-fulfilling prophecies in prediction markets.
  2. **Become the Casino.** The crypto market is filled with speculation. By providing liquidity, farming yields, and taking the other side of gamblers (e.g., selling Pendle PTs), you can generate consistent, lower-risk returns. Farmers, on average, outperform directional traders over the long term.
  3. **Alpha Lives in the Weeds.** The most significant opportunities aren’t on the front page of Twitter. They’re buried in obscure Discord servers, complex protocol mechanics (like Aerodrome’s bribes), and emerging platforms with low capital efficiency like Polymarket.
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August 22, 2025

Robinhood’s Vlad Tenev Claps Back: From Memecoins to Real Assets – The Chopping Block

Unchained

Crypto
Key Takeaways:
  1. Private Markets Are the New Public: The real unlock for tokenization isn't just 24/7 stock trading—it's bringing high-growth private companies to retail investors, with or without the company's blessing.
  2. The Great Convergence Is Here: The line between a crypto exchange and a stock brokerage is disappearing. Robinhood and its competitors are converging on a single "financial super app" model where all assets live in one place.
  3. Regulation Has Created a Paradox: The current system allows unlimited speculation on assets with zero fundamental value (memecoins) but blocks access to premier private equity. Robinhood is betting this logic won't hold.
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August 22, 2025

Bittensor Brief #5: $TAO = The Early Internet?

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

Crypto
Key Takeaways:
  1. Embrace the Friction: The current difficulty of investing in Bittensor subnets is a feature, not a bug. It’s the moat that has suppressed valuations, creating an opportunity akin to buying Bitcoin on Mt. Gox before Coinbase existed.
  2. A 3-6 Month Catalyst Window: The development of bridges and institutional infrastructure is the primary catalyst. This window represents the final moments to gain exposure before capital can flow in easily, likely re-rating the entire ecosystem.
  3. Think Startups, Not Just Tokens: Evaluate subnets like early-stage companies. Use resources like the *Revenue Search* podcast to analyze financials and projects like Shush (AI inference), Score (AI vision), and Quantum (public quantum computing) as real, venture-style bets.
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August 21, 2025

Bear or Bull Market? Institutions Are Buying The Dip! Crypto Markets Explained

Bankless

Crypto
Key Takeaways:
  1. **Don't Panic Sell.** The current market dip is a sign of a healthy "wall of worry," not a cycle top. Historical on-chain indicators show there is significant room to run.
  2. **Follow the Smart Money.** Institutions are aggressively buying this dip. The real capital from pensions and sovereign wealth funds is still on the sidelines, waiting to enter.
  3. **The Fed is Turning Bullish.** A key Federal Reserve official is now openly advocating for crypto adoption within the regulatory apparatus, signaling a major long-term shift in the US.
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August 20, 2025

The Fed Isn’t in Charge of the Dollar. The Eurodollar System Is.

Bankless

Crypto
Key Takeaways:
  1. **The Dollar Isn't Being Debased; It's Deflationary.** The market is not pricing in inflation or debasement. Instead, key indicators like the interest rate swap market are emphatically signaling a future of much lower interest rates for much longer, which is characteristic of deflationary pressure and a strong dollar.
  2. **Asset Booms Are a Symptom, Not a Solution.** Rising stock and crypto prices are not evidence of a healthy economy or money printing. They reflect a K-shaped recovery where capital flees into financial assets as a hedge against systemic fragility, while the real economy for labor remains stagnant.
  3. **The Contrarian Play Is Long Bonds.** If the global system is starved for safe, liquid collateral and headed toward a deflationary recession, the best-performing assets will be long-duration U.S. Treasuries. Snyder’s advice is the polar opposite of the typical crypto portfolio: be long bonds.
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August 20, 2025

Crypto Credit Markets Will Rewrite Risk Management | David Grider

Forward Guidance

Crypto
Key Takeaways:
  1. **Alpha Is Now Risk Management:** In a maturing crypto market, outperformance comes from actively managing gross exposure and utilizing a diverse strategy mix (equities, credit, derivatives), not just holding beta.
  2. **Crypto Credit Offers Unprecedented Asymmetry:** Instruments like convertible bonds on DATs provide credit-like downside protection while retaining crypto-like upside, creating a compelling opportunity for risk-adjusted returns that is often cheaper than replicating with native options.
  3. **The DAT Playbook Is Evolving:** The next cycle’s drama won't just be about token prices. Watch for DATs using leverage, building out their own "yield curves," and the eventual distressed cycle where activists and acquirers step in to capture NAV discounts.
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