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AI Podcasts

August 5, 2025

The New Era Of Distribution with Ram Kumar & Eowyn Chen

The Rollup

AI
Key Takeaways:
  1. A new economic model is emerging where AI and crypto converge, transforming how value is created and distributed.
  2. AI Is Becoming Specialized, Not Generalized. Forget one-size-fits-all AI. The future is in niche, fine-tuned models trained on proprietary data for specific tasks like DeFi optimization and on-chain security, making generic models like ChatGPT look like a blunt instrument.
  3. Your Wallet Is Your Paycheck. Crypto wallets are becoming the interface for a new data economy. Users will transition from being unpaid data sources to active contributors who get rewarded with tokens for training specialized AI models.
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August 4, 2025

Dwarkesh Patel and Noah Smith on AGI and the Economy

a16z

AI
Key Takeaways:
  1. Redefine AGI from Consciousness to Commerce. Forget Turing tests. The real benchmark for AGI is its ability to automate ~95% of white-collar work. The biggest missing piece isn't reasoning, but the capacity for continuous, on-the-job learning.
  2. Prepare for an Economic Singularity. Post-AGI growth won't be an incremental bump; it will be an explosive shift to 20%+ annual growth, driven by infinitely scalable AI labor. The bottleneck won't be human demand but the ambitions of the agents controlling the AI.
  3. The AGI Race Is More Industrial Revolution than Cold War. AGI is not a single bomb but a transformative process. The key risk isn't one nation nuking another, but advanced AIs playing nations against each other, much like the East India Company did in India.
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August 4, 2025

Micaela Bazo & Pedro Penna: AI, Drug Discovery, Decentralized Science, Behavioral Medicine | Ep 55

Ventura Labs

AI
Key Takeaways:
  1. Decentralize R&D for Efficiency. Using token-incentivized networks like Bittensor radically cuts costs and accelerates the initial drug discovery phase by tapping a competitive, global talent pool.
  2. Go Upstream for Bigger Wins. Targeting root "behavioral" causes of disease instead of just symptoms creates drugs with multi-condition applications, unlocking massive, previously unseen market potential.
  3. Innovate on Existing Rails. The fastest path to impact is by building on proven systems. Focusing on small molecules and using industry-standard validation partners creates a practical bridge between the worlds of crypto and traditional pharma.
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August 1, 2025

Will Market Euphoria Cool Off In August? | Weekly Round-Up

Forward Guidance

AI
Key Takeaways:
  1. Stagflation is Here: The Fed is poised to cut rates into rising inflation, an unorthodox move that signals how boxed-in monetary policy has become.
  2. The Two-Tiered Economy is Real: Capital is flowing to the "productive frontiers" of AI and tech, while legacy industries and the un-invested class get crushed. Policy is exacerbating this divide.
  3. Be Tactical, but Bet on the Ponzi: Expect a choppy August as euphoria cools. The long-term game, however, remains the same: bet on the assets that benefit from a global flight out of failing fiat and into productive, scarce technologies.
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August 1, 2025

MCP vs Browser Agents and Moving Beyond Crypto in the AI Space

Trillion Agents

AI
Key Takeaways:
  1. Crypto Is a Niche, Not a Foundation. AI builders are actively scrubbing crypto references from their branding to close enterprise deals. The market has decided: for now, crypto’s role is a payment rail, not the core agent stack.
  2. Bet on Native Protocols, Not Browsers. Browser-based agents are a dead end. The future belongs to agent-native protocols like MCP that enable efficient, bidirectional communication, mirroring the shift from mobile web to native apps.
  3. The AI Race Is a Power Race. The real bottleneck for AGI isn't just chips; it's energy. China's massive infrastructure build-out poses a strategic challenge to the West, which is betting on innovation in nuclear to keep pace. The future of AI may be decided by who can build power plants the fastest.
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July 31, 2025

How Distributed Compute Could Solve AI's Energy Crisis, w/ the CEO of Akash

The People's AI

AI
Key Takeaways:
  1. Energy is the New Scarcity. The race for AI supremacy is a race for power. Platforms like Akash that efficiently harness distributed, underutilized energy offer the only scalable alternative to the centralized model's impending energy crisis.
  2. The Tech is Maturing Rapidly. Asynchronous training and ZK-proofs (championed by projects like Jensen) are making permissionless global compute networks a reality. The performance gap with centralized systems is closing fast.
  3. The Mainstream is Buying In. A confluence of academic acceptance (at conferences like ICML) and favorable government policy (the White House's pro-open-source stance) is creating powerful tailwinds. The narrative has shifted from if decentralized AI is possible to how it will be implemented.
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July 31, 2025

The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)

Latent Space

AI
Key Takeaways:
  1. RLVR is the New SOTA for Solvable Problems: For tasks with clear right answers (code, math), RLVR is the state-of-the-art training method. The community is focused on scaling it, while RLHF remains the domain of fuzzy, human-preference problems.
  2. The Future is Search-Driven: GPT-4o’s heavy reliance on search is not a bug; it’s a feature. The hardest problem is no longer giving models tools, but training them to learn when to use them.
  3. Agents Need More Than Skills: The next leap in AI requires training for strategy, abstraction, and calibration. The goal is an AI that doesn’t just answer questions but efficiently plans its own work without wasting compute.
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July 31, 2025

China Open-Source, Compute Arms Race, Reordering Global Trade | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. China's Open-Source Models are Winning on Price & Performance. Chinese models offer ~90% of the intelligence of top US proprietary models for a fraction of the cost, driving massive global adoption and threatening to commoditize the model layer. An American open-source champion is desperately needed to compete.
  2. The "Cost is No Object" Compute Buildout is Reshaping the Market. A handful of private companies are spending at a loss to capture market share, fueled by VC. This creates a "sport of kings" dynamic that public companies can't match and makes pick-and-shovel players like Nvidia the biggest winners.
  3. The US Tariff Strategy is Working. Contrary to consensus, the administration's tariff gambit has secured favorable trade deals with the EU and Japan, generating hundreds of billions in revenue without causing significant consumer inflation, and setting the stage for a major renegotiation with China.
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July 31, 2025

Health Tech Founders: The Future of Care Is Personalized, Proactive—and AI-Powered

a16z

AI
Key Takeaways:
  1. Biology is the ultimate API for AI. The most impactful AI will be fed not just digital data but real-world biological signals. Companies are building the infrastructure to bring a user's biology online, turning abstract health data into a constant, actionable feed.
  2. Engagement metrics are being rewritten. Forget Daily Active Users. The new model is "intense, intentional engagement" during periods of need. Growth is a function of trust and real-world impact, where the best champions are users who have been genuinely helped.
  3. AI's role is augmentation, not automation. The goal isn't to replace doctors or therapists but to empower them. By translating noise into signal, AI lets human experts skip the data-sifting and focus on what they do best: solving problems.
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Crypto Podcasts

May 27, 2025

Is Bitcoin Heading To $150k?

1000x Podcast

Crypto
Key Takeaways:
  1. Bitcoin's Bullish Trajectory: Bitcoin is on a path to potentially reach $150k-$200k, supported by a low-hype, strong-setup environment and a more sophisticated investor base.
  2. Strategic Altcoin Hunting: Focus on revenue-generating altcoins with solid fundamentals (check DeFiLlama) and consider measured exposure to the burgeoning AI crypto sector.
  3. Prioritize Self-Custody: Given exchange vulnerabilities, holding your assets offline in cold storage is more critical than ever.
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May 27, 2025

Empire Cross-Post: The Bull Case For Ethereum | Tom Dunleavy & Ryan Berckmans

Bell Curve

Crypto
Key Takeaways:
  1. L1 is HQ: Ethereum's "pivot" reasserts the L1's central role, supported by L2s that offer crucial business model diversity and customization for the world coming on-chain.
  2. Value Accrual via Security & Confidence: ETH's valuation is increasingly tied to the total economic value it secures and the market's confidence in its future, not just direct fee revenue.
  3. Business Development is Crucial: To compete and grow, Ethereum requires a significantly more robust and proactive go-to-market strategy to attract users, institutions, and developers.
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May 27, 2025

The Altseason Rotation Has Begun! Here's The Data Behind the Next Rotation

Bankless

Crypto
Key Takeaways:
  1. Rotation Imminent: Data suggests Bitcoin's strength is setting the stage for capital to flow into altcoins, particularly Ether, which is seen as "hated" and due for a rebound against Bitcoin.
  2. Macro is Bullish (For Now): Continued fiscal spending and an anticipated stablecoin bill are significant tailwinds, though summer may bring some turbulence.
  3. Strategic Allocation is Key: Focus on assets with strong fundamentals or high attention. Consider beta plays like "blue-chip" meme coins (Pepe for ETH, Bonk for SOL) for higher-risk, higher-reward exposure, but plan exits for speculative positions.
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May 27, 2025

Travis Millott: Tao Templar, Bittensor Subnets, Dynamic Tao, Mining, Crypto Education | Ep. 44

Ventura Labs

Crypto
Key Takeaways:
  1. Dynamic Tao is High-Risk: Approach investments with extreme caution; the market is volatile, and significant capital loss is a tangible risk.
  2. Embrace Unpredictable Innovation: Bittensor's core value lies in its capacity to generate unforeseen, groundbreaking solutions from a global, permissionless, and competitive talent pool.
  3. Substrate Chain Decentralization is Critical: The successful decentralization of Bittensor's foundational layer is a paramount upcoming milestone for its long-term viability, security, and censorship resistance.
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May 26, 2025

The Bitcoin Treasury Playbook With Tyler Evans & Josh Solesbury

Empire

Crypto
Key Takeaways:
  1. Global Takeover: Bitcoin treasury strategies are rapidly globalizing, creating new Bitcoin-proxy investment vehicles in numerous capital markets.
  2. Investor Vigilance: While "Bitcoin plus" returns are alluring, investors must critically assess MNAV multiples and beware of highly leveraged companies lacking strong, transparent leadership.
  3. Reverse Tokenization is Real: Crypto assets are increasingly entering traditional finance via these public companies, fundamentally changing institutional access and perception.
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May 26, 2025

Why Analysts Are Valuing ETH All Wrong

Bankless

Crypto
Key Takeaways:
  1. **L1s are Money, Not Stocks:** Stop trying to fit square pegs (L1s) into round holes (DCF models for companies). Their value accrues like money, through network effects and demand for their monetary properties.
  2. **RSOV is Your New Lens:** Use RSOV to gauge the "stickiness" of capital in an L1 ecosystem. A growing RSOV suggests a strengthening monetary base and potentially a rising valuation floor.
  3. **ETH's RSOV Story:** ETH, when viewed through the RSOV lens, appears undervalued relative to assets like Bitcoin, especially considering catalysts like EIP-4844 ("proto-danksharding") and the growth of its L2 ecosystem, which drives ETH's use as a store of value.
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