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AI Podcasts

February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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February 4, 2026

⚡️ Context graphs: AI’s trillion-dollar opportunity — Jaya Gupta, Ashu Garg, Foundation Capital

Latent Space

AI
Key Takeaways:
  1. The shift from "how" to "why" in AI agent capabilities creates a new, multi-trillion-dollar market for companies that can capture institutional decision logic.
  2. Invest in or build agentic systems that are in the "right path" of business processes, actively capturing decision traces from unstructured data.
  3. Hundreds of context graphs will be in production at scale within a year, defining a new "context graph stack." The winning companies will be those that master this flywheel, extracting value to accelerate automation and build deep, defensible moats.
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February 2, 2026

We Entered an Era Where No One Knows What Comes Next

Turing Post

AI
Key Takeaways:
  1. The shift from linear, bottleneck-driven technological progress to a multi-layered, interconnected advancement model in AI has rendered traditional forecasting obsolete, forcing a re-evaluation of what "singularity" truly represents.
  2. Prioritize adaptability: Invest in modular, composable AI infrastructure and tools that thrive in multi-layered, unpredictable environments, rather than betting on single-bottleneck solutions.
  3. The inability to narrate AI's future means traditional roadmaps are obsolete; success hinges on navigating simultaneous, interconnected advancements and embracing the emergent.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The era of infrastructure-heavy tech deployment is over; AI's internet-native nature means immediate, widespread application. This shifts the competitive advantage from capital-intensive builds to rapid iteration and data leverage.
  2. Invest in companies that are not just using AI, but are fundamentally rethinking their business models around AI's ability to collapse traditional cost structures and accelerate product development.
  3. AI is a force multiplier for both individual opportunity and national power. Understanding its immediate deployability and the new rules of company building is crucial for investors and builders aiming to lead in the next wave of innovation over the next 12-24 months.
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February 2, 2026

Ben Horowitz and David Solomon: The Sweetest Macro Spot in 40 Years

a16z

AI
Key Takeaways:
  1. Unprecedented fiscal and monetary stimulus, coupled with a deregulatory environment, creates a powerful tailwind for financial assets and tech, driving a capital investment super cycle.
  2. Investors should prioritize companies with proprietary data and GPU access, as these are the new moats in an AI-driven world where traditional software leads are eroding.
  3. The convergence of a stimulative macro environment and AI's disruptive force means capital will flow to those who can scale, innovate, and navigate complex policy landscapes, making strategic positioning now critical for future relevance.
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Crypto Podcasts

August 8, 2025

Is TradFi Buying Our Bags? Why Jordi Owns Zero Stocks!!

Steady Lads Podcast

Crypto
Key Takeaways:
  1. **Play Offense or Get Diluted.** The dollar is devaluing faster than official numbers suggest. Sitting in cash or even diversified index funds may not be enough to preserve wealth. An offensive strategy, focused on assets like Bitcoin that can outpace this devaluation, is essential.
  2. **This Isn't 2021.** Don’t mistake short-term liquidity pumps for a sustained bull market. The market structure favors quick rotations and profit-taking, not long-term holds on unproven altcoins.
  3. **Attention is the New Scarcity.** The memecoin and launchpad meta is saturated. Most projects are ephemeral, designed for a quick flip. Long-term value will likely come from projects that can solve the attention decay problem or create sustainable revenue models.
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August 8, 2025

The Solana Seeker Phone Is Here | Emmett Hollyer

Lightspeed

Crypto
Key Takeaways:
  1. Hardware is the Trojan Horse: The Seeker phone isn't the endgame; it's the proof-of-concept. The real vision is TPIN, a network that allows any hardware manufacturer to integrate Solana's secure, crypto-native mobile stack.
  2. A Breakout App is Non-Negotiable: The platform's success depends on developers building a "viral" app that is only possible in this open, crypto-friendly environment. Watch for "Seeker Season" and hackathon results as key indicators of traction.
  3. The SKR Token is Pure Utility: SKR is designed to be the economic glue for the TPIN ecosystem. For investors, its value is tied not to a speculative cash grab but to the growth and security of a new, decentralized mobile platform.
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August 7, 2025

Is Coding a Crime? Roman Storm Tornado Cash Verdict

Bankless

Crypto
Key Takeaways:
  1. Guilty by Definition. The verdict was a product of a legal trap; the judge’s instructions forced the jury to view Roman as a money transmitter, a premise that directly contradicts FinCEN's own guidance and is the central issue for appeal.
  2. A Threat to All of DeFi. The DOJ’s legal theory is boundless. It weaponizes a low "knowledge" standard that could hold any developer liable for the actions of their users, putting the entire non-custodial ecosystem at risk.
  3. Three Paths to Victory. The crypto industry has three shots on goal to fix this: Roman’s direct appeal, a preemptive legal challenge in a separate case, and passing the Blockchain Regulatory Certainty Act (BRCA) to create hardcoded legal protections for developers.
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August 7, 2025

When Will Companies IPO Onchain?

Lightspeed

Crypto
Key Takeaways:
  1. Accountability Unlocks Adoption: The biggest barrier isn't tech, but inertia. Until executives are held accountable for incinerating billions in mispriced IPOs, the broken system will persist. The path to onchain IPOs is paved by firing the people who get it wrong in TradFi.
  2. Onchain Auctions Are IPO 2.0: Blockchains replace the "guy with a spreadsheet" with transparent, permissionless auctions. This ensures fair price discovery and prevents the insider discounts that lock out the public.
  3. The First Domino Starts a Cascade: Regulatory winds are shifting (e.g., the SEC's "Project Crypto"). The moment one major company successfully IPOs onchain, the perceived career risk will flip, opening the floodgates for others to follow.
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August 6, 2025

The World’s Largest ETH Holder - Tom Lee on Treasuries, Ethereum Dominance, and Wall Street

Bankless

Crypto
Key Takeaways:
  1. ETH Treasuries are Infrastructure, Not ETFs: These companies are active players, using staking yield, MNAV premiums, and balance sheet velocity to accumulate ETH. Bitmine’s goal to own 5% of all ETH positions it as a key, US-compliant entity for Wall Street’s on-chain future.
  2. This is ETH's "2017 Bitcoin Moment": Wall Street is beginning to recognize Ethereum as the settlement layer for tokenization and AI. This institutional awakening creates the potential for a massive step-function price increase as capital flows in.
  3. The Upside Case for ETH > Bitcoin: Tom Lee argues Ethereum has a greater asymmetric upside, with a potential 100x return and a "significant probability" of flipping Bitcoin in network value. The investment thesis is based on this expansive vision, not myopic spreadsheet models.
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August 6, 2025

Karia Samaroo: xTAO Bittensor Treasury, Validators, Subnets, Crypto AI Investing | Ep. 56

Ventura Labs

Crypto
Key Takeaways:
  1. It’s an Operating Company, Not Just a Vault: xTAO’s strategy is to actively build validators and infrastructure, using its public listing as a flywheel for accretive TAO acquisition, rather than passively holding the asset.
  2. Structure is Strategy: The combination of a low-cost TSXV listing and a tax-free Cayman Islands headquarters gives xTAO a significant operational and financial edge designed for long-term sustainability.
  3. The Next Frontier is User Adoption: For Bittensor to reach its potential, it must break out of the crypto bubble. The ecosystem's ultimate success hinges on subnets creating useful products that attract mainstream users.
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