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AI Podcasts

May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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Crypto Podcasts

August 30, 2025

Is Hyperliquid The Wild West? Has The Market Topped?! w/ Dim Selk

Steady Lads Podcast

Crypto
Key Takeaways:
  1. **The Market Is Cooked.** With momentum buyers exhausted and value buyers absent, the risk/reward on majors like BTC and ETH is heavily skewed to the downside. The party may not be over, but it's time to find the exit.
  2. **DEXs Are Not CEXs.** Decentralized perpetual exchanges like Hyperliquid offer unparalleled access but lack the circuit breakers and centralized oversight of a Binance. In these venues, you are the risk manager, and there is no sheriff coming to save you.
  3. **Beware OG Whales.** The market is still heavily influenced by a small number of early crypto holders operating with immense capital and unsophisticated "ape first, research later" strategies. Their unpredictable actions can and will create violent dislocations.
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August 29, 2025

ETH Hits New ATH! Powell Hints at Rate Cuts & BTC Whales Rotate to ETH

Bankless

Crypto
Key Takeaways:
  1. **The Fed's dovish turn is the primary market catalyst.** Powell's signals of impending rate cuts have injected massive optimism, driving ETH to a new all-time high and confirming that macro now dictates crypto's direction.
  2. **Capital is aggressively rotating from Bitcoin to Ether.** This classic cycle rotation, amplified by whale activity and trader expectations, is a self-fulfilling prophecy, positioning ETH as the next dominant asset to watch.
  3. **The Solana treasury narrative is the next frontier.** With the window closing for new Bitcoin and ETH treasury vehicles, a fierce competition is underway to establish the dominant, "Saylor-like" figurehead for Solana, creating a new focal point for institutional capital.
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August 29, 2025

NFTs As Top Signals

Empire

Crypto
Key Takeaways:
  1. **Track NFT Blue-Chips as a Signal.** The price action of collections like CryptoPunks acts as a potent gauge for the "wealth effect" and overall risk appetite within the crypto ecosystem. Their peaks often correlate with broader market tops.
  2. **Separate Collecting from Investing.** Frame high-end NFT acquisitions as an "expense" for art you genuinely love, not a financial investment. This strategy decouples your emotional well-being from market volatility.
  3. **Embrace Your Top-Signal Buys.** An expensive purchase at a market peak isn't just a loss; it's a powerful lesson in humility. Use it as a constant reminder that no one is immune to market psychology.
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August 27, 2025

How to Make it This Cycle w/ CryptoMessi

Taiki Maeda

Crypto
Key Takeaways:
  1. Ditch the Rotator Playbook. This isn't 2021. Stop chasing every pump. Success this cycle requires picking a few narratives, believing in them, and holding with conviction.
  2. Make On-Chain Money Real. Stablecoins encourage bad habits. Cash out profits to a real bank account to create a psychological barrier against recklessly aping your gains back into the market.
  3. Plan for Post-Win Depression. The dopamine crash after a massive score is inevitable. Resist the urge to chase that high; prioritize building sustainable, real-world income instead of buying status symbols.
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August 27, 2025

Trump’s Tariffs Could Stall Growth Before 2026 Surge | Alfonso Peccatiello

Forward Guidance

Crypto
Key Takeaways:
  1. A Politicized Fed is the Baseline. Assume the Federal Reserve will be pressured to cut rates to neutral (~3%) by 2026, creating an unusually loose policy backdrop relative to strong nominal growth.
  2. Mind the Fiscal Cliff, Then the Rocket Ship. Brace for a temporary growth slowdown as tariffs bite over the next few months, but prepare for a sharp re-acceleration in 2026 if and when new stimulus kicks in.
  3. Ditch Old Hedges, Buy Protest Assets. Your portfolio's traditional diversifiers (long bonds, USD) are broken. Shift allocation toward assets that benefit from inflation risk and high nominal growth: commodities, crypto, and undervalued international equities.
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August 26, 2025

Ep 46 — How to Turn a Dying NFT Collection into a $50M Cultural Empire in Web3 ft. Luca Netz

The DCo Podcast

Crypto
Key Takeaways:
  1. **Valuation is Evolving.** The most durable crypto projects will be judged not on tokenomics alone, but on a triad of community strength (Ecosystem), marketing reach (Attention), and real-world cash flow (Revenue).
  2. **Centralization Wins the Consumer.** The next billion users will not navigate a dozen dApps. They will be onboarded through simplified, centralized super-apps that provide a seamless and curated on-chain experience.
  3. **Reward Loyalty, Not Speculation.** Sustainable value is built by aligning with true believers. Founders should design mechanisms that reward long-term holders and actively discourage "farm-and-dump" behavior.
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