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AI Podcasts

December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Strategic Implication: The next frontier in AI is agentic, and progress hinges on fundamental pre-training innovation, not just post-training optimizations.
  2. Builder/Investor Note: Focus on teams with deep experience in scaling and debugging large models, as this is a high-capital, high-risk endeavor. Builders should prioritize developing new benchmarks for agentic capabilities.
  3. The "So What?": The industry needs to move beyond next-token prediction and static benchmarks to unlock truly capable, self-correcting AI agents in the next 6-12 months.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Shift in AI Development: The focus moves from syntax-aware code generation to execution-aware reasoning, enabling more robust and intelligent code agents.
  2. Builder/Investor Note: Prioritize tools and platforms that support explicit execution modeling and highly asynchronous, high-throughput RL training for agentic systems.
  3. The "So What?": AI that can simulate complex systems internally will drastically reduce development and testing costs, accelerating innovation in software and distributed systems over the next 6-12 months.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI-driven kernel generation is not replacing human genius but augmenting it, allowing experts to focus on novel breakthroughs while AI automates the application of known optimizations across a complex hardware landscape.
  2. Builder/Investor Note: Focus on robust validation and hardware-in-the-loop systems. Claims of "AI inventing new algorithms" in this domain are premature. The real value is in automating the "bag of tricks" for heterogeneous compute.
  3. The "So What?": This technology is critical for scaling agentic AI workloads. Expect significant investment in tools that abstract hardware complexity and enable efficient, automated optimization, driving down the cost of AI inference in the next 6-12 months.
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December 18, 2025

AI Consulting in Practice – NLW, Super ai

AI Engineer

AI
Key Takeaways:
  1. The Agent Economy is Here: Enterprises are moving past pilots with AI agents. Builders should focus on orchestration layers and human-agent interaction design.
  2. ROI Measurement is the Next Frontier: Investors should look for solutions that help organizations accurately track and attribute AI value beyond traditional metrics.
  3. Strategic AI, Not Spot Solutions: The biggest wins come from systematic, cross-organizational AI strategies that target new capabilities and revenue growth, not just incremental time savings.
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December 18, 2025

How to build an AI native company (even if your company is 50 years old) – Dan Shipper, Every

AI Engineer

AI
Key Takeaways:
  1. The 100% AI adoption threshold is a step-function change, not incremental. Companies that commit fully will outpace those with partial integration.
  2. Builders should prioritize "compounding engineering" by codifying knowledge into reusable prompts. This builds an organizational memory that accelerates future development exponentially.
  3. Re-evaluate team structures and roles. Single engineers can own complex products, and even technical managers can contribute code, shifting how organizations operate.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. Effective crime reduction requires a shift from reactive punishment to proactive, intelligence-driven deterrence, making it highly probable for criminals to be caught.
  2. The market for AI-powered public safety technology, particularly solutions that integrate data for precision and accountability, presents a significant opportunity. Public-private partnerships are a key funding mechanism.
  3. Over the next 6-12 months, expect to see more cities adopt advanced surveillance and AI tools, driven by private funding, as they seek to improve safety and address staffing shortages without resorting to ineffective, broad-stroke policies.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade will be defined by who builds the core infrastructure for intelligence. This is where the most significant value and influence will accrue.
  2. Builder/Investor Note: Direct capital and talent towards foundational AI components—chips, models, and interoperable systems. Avoid the temptation to only build at the application layer.
  3. The So What?: The window for shaping the future of intelligence is now. Engage in the deepest, most complex challenges to secure a footprint in this new era.
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December 18, 2025

The EU and the not-so-simple macroeconomics of AI – Luis Garicano

Epoch AI

AI
Key Takeaways:
  1. Strategic Implication: The global AI race is a zero-sum game for foundational models. Europe's best strategy is a "smart second mover" approach, focusing on the implementation layer by ensuring interoperability and data portability.
  2. Builder/Investor Note: Invest in AI that achieves true autonomy and enhances expert productivity. Be wary of markets stifled by over-regulation, which can impede AI adoption and growth.
  3. The "So What?": Europe faces a critical juncture. Without embracing AI-driven growth, its demographic and debt problems will worsen, leading to higher interest rates without the corresponding economic expansion.
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December 18, 2025

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)

Latent Space

AI
Key Takeaways:
  1. Vision AI Democratization: SAM 3 lowers the barrier for sophisticated vision tasks, making advanced segmentation and tracking accessible for a wider range of applications.
  2. Builder/Investor Note: Focus on domain-specific adaptations and tooling that enhance human-AI interaction for ambiguous visual concepts. The "last mile" of user intent is a key differentiator.
  3. The "So What?": SAM 3 accelerates the development of multimodal AI, particularly in robotics and video analysis, by providing a robust, scalable visual foundation for the next generation of intelligent systems.
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Crypto Podcasts

August 24, 2025

Will LINK Flip XRP? with Zach Rynes

The Rollup

Crypto
Key Takeaways:
  1. Bet on the Ecosystem, Not the Silo: Chainlink’s value is tied to the growth of the entire blockchain space, making it a diversified bet on institutional adoption. XRP’s success is a narrow wager on its own ledger and asset gaining dominance.
  2. Follow the Proof, Not the Promises: Chainlink’s public partnerships with firms like Swift and JP Morgan provide concrete evidence of traction. This stands in sharp contrast to XRP's long-unfulfilled, NDA-shrouded narrative.
  3. Infrastructure is the Ultimate Power Play: By providing a comprehensive suite of essential services (data, cross-chain, compliance), Chainlink is building a defensible moat as the go-to infrastructure platform for Web3, with no direct all-in-one competitor in sight.
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August 23, 2025

Former Yahoo Music Executive on Crypto's Inevitable Centralization Points with Ian Rogers

The Rollup

Crypto
Key Takeaways:
  1. **Value is a Function of Time:** Bitcoin's greatest asset is its 15-year track record. Lasting value isn't about technology alone; it's about a powerful story that withstands the test of time, creating an insulated brand.
  2. **Self-Custody is the Premise:** The entire value proposition of crypto hinges on eliminating counterparty risk. Compromising on self-custody and security for the sake of convenience is a recurring mistake that "always blows up."
  3. **Adoption Will Be Abstracted:** The future of crypto for the masses is one where the complexity is hidden. Centralized user experiences will run on decentralized rails, delivering the benefits of crypto (lower fees, faster settlement) without the unforgiving user experience.
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August 22, 2025

Making $5M in Unconventional Trades w/ 0xLaw

Taiki Maeda

Crypto
Key Takeaways:
  1. **Stop Gambling, Start Engineering.** The biggest edge isn’t in predicting price but in finding and exploiting structural market inefficiencies. Focus on trades where you can control or heavily influence the outcome, like RFV plays or creating self-fulfilling prophecies in prediction markets.
  2. **Become the Casino.** The crypto market is filled with speculation. By providing liquidity, farming yields, and taking the other side of gamblers (e.g., selling Pendle PTs), you can generate consistent, lower-risk returns. Farmers, on average, outperform directional traders over the long term.
  3. **Alpha Lives in the Weeds.** The most significant opportunities aren’t on the front page of Twitter. They’re buried in obscure Discord servers, complex protocol mechanics (like Aerodrome’s bribes), and emerging platforms with low capital efficiency like Polymarket.
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August 22, 2025

Robinhood’s Vlad Tenev Claps Back: From Memecoins to Real Assets – The Chopping Block

Unchained

Crypto
Key Takeaways:
  1. Private Markets Are the New Public: The real unlock for tokenization isn't just 24/7 stock trading—it's bringing high-growth private companies to retail investors, with or without the company's blessing.
  2. The Great Convergence Is Here: The line between a crypto exchange and a stock brokerage is disappearing. Robinhood and its competitors are converging on a single "financial super app" model where all assets live in one place.
  3. Regulation Has Created a Paradox: The current system allows unlimited speculation on assets with zero fundamental value (memecoins) but blocks access to premier private equity. Robinhood is betting this logic won't hold.
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August 22, 2025

Bittensor Brief #5: $TAO = The Early Internet?

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

Crypto
Key Takeaways:
  1. Embrace the Friction: The current difficulty of investing in Bittensor subnets is a feature, not a bug. It’s the moat that has suppressed valuations, creating an opportunity akin to buying Bitcoin on Mt. Gox before Coinbase existed.
  2. A 3-6 Month Catalyst Window: The development of bridges and institutional infrastructure is the primary catalyst. This window represents the final moments to gain exposure before capital can flow in easily, likely re-rating the entire ecosystem.
  3. Think Startups, Not Just Tokens: Evaluate subnets like early-stage companies. Use resources like the *Revenue Search* podcast to analyze financials and projects like Shush (AI inference), Score (AI vision), and Quantum (public quantum computing) as real, venture-style bets.
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August 21, 2025

Bear or Bull Market? Institutions Are Buying The Dip! Crypto Markets Explained

Bankless

Crypto
Key Takeaways:
  1. **Don't Panic Sell.** The current market dip is a sign of a healthy "wall of worry," not a cycle top. Historical on-chain indicators show there is significant room to run.
  2. **Follow the Smart Money.** Institutions are aggressively buying this dip. The real capital from pensions and sovereign wealth funds is still on the sidelines, waiting to enter.
  3. **The Fed is Turning Bullish.** A key Federal Reserve official is now openly advocating for crypto adoption within the regulatory apparatus, signaling a major long-term shift in the US.
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