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AI Podcasts

February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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February 4, 2026

⚡️ Context graphs: AI’s trillion-dollar opportunity — Jaya Gupta, Ashu Garg, Foundation Capital

Latent Space

AI
Key Takeaways:
  1. The shift from "how" to "why" in AI agent capabilities creates a new, multi-trillion-dollar market for companies that can capture institutional decision logic.
  2. Invest in or build agentic systems that are in the "right path" of business processes, actively capturing decision traces from unstructured data.
  3. Hundreds of context graphs will be in production at scale within a year, defining a new "context graph stack." The winning companies will be those that master this flywheel, extracting value to accelerate automation and build deep, defensible moats.
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February 2, 2026

We Entered an Era Where No One Knows What Comes Next

Turing Post

AI
Key Takeaways:
  1. The shift from linear, bottleneck-driven technological progress to a multi-layered, interconnected advancement model in AI has rendered traditional forecasting obsolete, forcing a re-evaluation of what "singularity" truly represents.
  2. Prioritize adaptability: Invest in modular, composable AI infrastructure and tools that thrive in multi-layered, unpredictable environments, rather than betting on single-bottleneck solutions.
  3. The inability to narrate AI's future means traditional roadmaps are obsolete; success hinges on navigating simultaneous, interconnected advancements and embracing the emergent.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The era of infrastructure-heavy tech deployment is over; AI's internet-native nature means immediate, widespread application. This shifts the competitive advantage from capital-intensive builds to rapid iteration and data leverage.
  2. Invest in companies that are not just using AI, but are fundamentally rethinking their business models around AI's ability to collapse traditional cost structures and accelerate product development.
  3. AI is a force multiplier for both individual opportunity and national power. Understanding its immediate deployability and the new rules of company building is crucial for investors and builders aiming to lead in the next wave of innovation over the next 12-24 months.
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February 2, 2026

Ben Horowitz and David Solomon: The Sweetest Macro Spot in 40 Years

a16z

AI
Key Takeaways:
  1. Unprecedented fiscal and monetary stimulus, coupled with a deregulatory environment, creates a powerful tailwind for financial assets and tech, driving a capital investment super cycle.
  2. Investors should prioritize companies with proprietary data and GPU access, as these are the new moats in an AI-driven world where traditional software leads are eroding.
  3. The convergence of a stimulative macro environment and AI's disruptive force means capital will flow to those who can scale, innovate, and navigate complex policy landscapes, making strategic positioning now critical for future relevance.
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Crypto Podcasts

August 14, 2025

My $1,000,000 Crypto Playbook, Revealed

blocmates.

Crypto
Key Takeaways:
  1. **Right vs. Rich:** Stop trying to be right; focus on being profitable. Buy things you think are stupid if you believe the market will value them. The best trades often feel viscerally wrong.
  2. **Master the Modes:** The market operates in two modes. In "Easy Mode," go hard on early trends with concentrated size. In "Hard Mode," your only job is capital preservation. Hit the sell button and wait.
  3. **De-Risk Like a Pro:** When you feel like a genius and start looking at houses, it's time to cash out. Aggressively take 80%+ off the table to lock in your life-changing gains and protect your mental health. Opportunity is constant; your capital is not.
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August 13, 2025

Phantom CEO: Will Phantom IPO In The Future?

Lightspeed

Crypto
Key Takeaways:
  1. Mission Over Markets: Phantom will only consider an IPO if it directly serves its primary mission of bringing crypto mainstream. The decision is strategic, not reactive to market trends or a desire for validation.
  2. Discipline by Default: The company operates with the financial and operational rigor of a public entity, modeling itself after Coinbase, without taking on the regulatory burdens of an actual IPO.
  3. Complexity is a Cost: Avoiding the operational complexity of a public listing is a competitive advantage, enabling the team to allocate 100% of its resources toward building the business.
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August 12, 2025

Did ETH Just Trigger An Alt Season?

1000x Podcast

Crypto
Key Takeaways:
  1. Bet on the ETH Ecosystem. The bounce off cycle lows signals the start of an ETH-centric alt season. Look for opportunities within its ecosystem, as rising ETH prices create positive feedback loops for its native DeFi protocols.
  2. Aerodrome is a Top Pick on Base. AERO presents a compelling investment case due to its superior tokenomics, strong product-market fit on Base, lack of VC overhang, and recent technical breakout. It is positioned to capture massive value as Base grows.
  3. On-Chain Adoption Will Come Through CEXs. The most significant long-term catalyst is the seamless integration of on-chain ecosystems into centralized exchanges. This makes Base-native projects the primary beneficiaries of the next wave of retail adoption, driven by Coinbase.
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August 12, 2025

Most Common Founder Questions a16z Crypto Fields

Empire

Crypto
Key Takeaways:
  1. The conversation has shifted from "Can we build this?" to "How do we grow this?" Founders are now focused on shipping products, forging partnerships, and hiring talent, signaling a decisive move from infrastructure to business execution.
  2. Regulation is focusing on code, not conduct. The move to a "control-based" decentralization framework means what matters is how technically neutral your system is, not who is in your Slack channel.
  3. With scaling solved, UX is the new bottleneck. The industry has moved past the gas wars; the next great challenge is creating intuitive user experiences through better wallet design and key management.
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August 12, 2025

Bits + Bips LIVE: Crypto + Macro News & Analysis - August 11, 2025

Unchained

Crypto
Key Takeaways:
  1. Follow the Flows. Ethereum's rally is a direct result of capital firehoses from new treasury companies. This isn't a narrative trade; it's a structural buying pressure that creates its own momentum.
  2. Yield is Widening. As TradFi rates fall, on-chain credit yields are set to expand. The widening spread between traditional and decentralized finance will be a powerful magnet for capital.
  3. The Treasury Gold Rush Has Begun. The explosion of new treasury companies is a land grab for asset accumulation. The real game will be fought on operational efficiency, yield generation, and brand dominance, leading to inevitable consolidation.
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August 11, 2025

Did ETH Just Signal Alt Season?

1000x Podcast

Crypto
Key Takeaways:
  1. ETH is the bellwether for risk. Its current rally is the starting gun for an "ETH alt season." Use ETH's strength as a barometer for when to be aggressive with altcoin allocations.
  2. Buy breakouts, not bottoms. The most profitable strategy is to wait for assets to break their downtrend, then ride the reflexive narrative loop. Aave (AAVE) and Aerodrome (AERO) are prime examples of this setup.
  3. Aerodrome is a conviction play. With superior tokenomics, a dominant position on Base, and a direct pipeline to Coinbase's retail army, Aerodrome has a clear path to becoming a breakout star of this cycle.
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