Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
The Interface is the Bottleneck. Today's chatbots are the MS-DOS of AI. The next trillion dollars of value will be unlocked not by the models themselves, but by the new "Windows/Mac OS" interface that makes AI accessible and useful for everyone.
Every Creator Will Build Software. The distinction between a content creator and a software developer is collapsing. The next platforms will empower anyone to build mini-apps, turning software into a new medium for community, expression, and monetization.
Ditch the Voice-Only Dream. The Her-inspired fantasy of a screenless, voice-only AI future is a dead end. The winning AI device will be screen-first, built around an AI-native OS that makes software deeply personal and context-aware.
Culture is the Newest Yield-Bearing Asset: Arya Protocol proves that intellectual property, from music royalties to digital art, can be tokenized into stable, income-generating investments, moving beyond crypto’s speculative roots.
Fintech's Crypto FOMO is Reshaping Finance: The race is on. Traditional payment giants are rapidly adopting stablecoins, not as a gimmick, but as a critical infrastructure upgrade for building faster, cheaper, and more inclusive global financial products.
Money is Becoming Natively Programmable for AI: The future of commerce and finance will be run by AI agents. Stablecoins provide the missing piece—a programmable, automated payment layer that bypasses the friction of traditional banking, unleashing a new wave of economic activity.
**Structure Dictates Speed:** A flat hierarchy with small, autonomous teams is the key to maintaining startup velocity at scale. Extreme ownership is the goal; traditional corporate structures are the enemy.
**Align Incentives, Explicitly:** As a company matures, passion gives way to process. In sales, commissions become a lagging indicator of strategy. Ensure incentive structures explicitly reward strategic decisions, not just closing any deal.
**Balance Ambition with Delivery:** Don't let the quest for a perfect, research-led solution kill your product momentum. Implement clear rules to decide when to ship a practical fix now and when to wait for the scientific breakthrough.
AI Skill Markets are the New Talent Pools: Protocols can now create bespoke competitions to source top-tier AI agents for specialized tasks, bypassing traditional R&D cycles and finding the best "minds" for the job.
The Protocol Will Build Itself: Recall's endgame is a self-improving system where AI agents compete to write and enhance the code of the very protocol they operate on, blurring the line between user and creator.
Performance Becomes the Contract: The future of AI work is a meritocracy where competitive arenas are directly tied to real capital and business lines, automatically allocating work to the most capable agents.
Unleash Innovation to Win. America's path to AI supremacy is through deregulation, abundant energy, and aggressive global exports. Over-regulating our own companies simply hands markets and momentum to China.
Fight for an Open AI Ecosystem. The most pressing AI threat is not existential risk but the creation of a centralized, Orwellian control system. This is enabled by regulatory capture and "woke AI" mandates disguised as safety.
Crypto Needs Clarity, Not Chaos. While AI requires a light touch, the crypto industry needs the opposite: clear, stable, and legislated rules. Ending the "regulation by enforcement" era is critical to bringing innovation back onshore and establishing the U.S. as the world's crypto capital.
Human data is the critical asset. The most valuable—and least glamorous—layer of the AI stack is human intelligence. Its scale, importance, and economic value will only grow.
The future is human-in-the-loop. The next phase of AI development will be defined by agent-human interaction, where automated systems can call upon verified human experts on demand for review and guidance.
Expertise will be licensed. The economic model is shifting toward a future where human expertise can be licensed, allowing individuals to earn passive income for contributing their knowledge to improve AI, much like Spotify pays artists for their music.
**Infrastructure is the New Frontier:** Prioritize crypto ventures using blockchain as a foundational layer to innovate and compete with Web2, moving beyond purely crypto-centric applications.
**Solve Real Problems, Not Chase Hypotheses:** True PMF stems from addressing tangible user pain points; market creation is often a byproduct of successful problem-solving, not an initial goal.
**Large Markets Fuel Pivots:** While a sharp focus is vital, building within a substantial market provides the necessary runway and adjacent opportunities critical for navigating the path to PMF.
UX is King: Seamless, integrated user experiences (like Hyperliquid's or a desired "Robin Hood for crypto") will win, as fragmentation (EVM L2s) breeds user frustration and churn.
Solana's Ascent: Alpenlow’s 150ms finality and zero voting costs significantly enhance Solana's competitive edge, driven by an "underdog" culture of relentless improvement.
ETH's Identity Search: Ethereum needs decisive leadership and a unified technical/narrative strategy to counter fragmentation and challengers; price pressure often serves as its main catalyst for action.
**Hyperliquid (Hype) is King:** Flood states, "It's the only asset that matters in crypto other than Bitcoin... Nothing else makes money," citing its strong fundamentals and mispricing.
**L1s are Uninvestable Commodities:** Focus on applications and frontends that directly serve users; L1s are a race to the bottom on fees and vulnerable to tech disruption.
**Builder Codes Fuel an Ecosystem:** Hyperliquid's permissionless monetization will attract a wave of development, creating a moat through network effects and specialized user experiences.
Treasury Tactics: The "treasury company" model is the new "low float, high FDV" game, but relies on continued premium valuations and favorable debt markets; watch out for stress when debt matures.
Sui's Pragmatism: Sui’s handling of the Cetus hack signals that newer chains may prioritize decisive action and recovery over decentralization purity in crises, a trend likely to continue.
Solana's Evolution: Solana’s major consensus upgrade, developed by former critics, showcases a pragmatic, engineering-first approach focused on performance and validator accessibility, potentially strengthening its L1 position.
Crypto Delivers Utility: Stablecoins move trillions monthly, proving crypto's real-world value beyond speculation for fast, cheap global payments.
AI Rewrites Web Economics: AI's direct-answer capability breaks the old ad-traffic model. Crypto offers tools to build the new economic "covenant" required.
Bet on Category Kings: Tech markets are "winner-take-all." Focus on the dominant player in any credible category, especially those led by founders with unique, "earned secrets."
Build Real, Not Just Rallies: Prioritize long-term, sustainable businesses with tangible revenue models over chasing fleeting crypto trends.
Utility Tokens Trump Speculation: Design tokens to solve core project problems or incentivize user behavior, not merely for market hype.
Solana's Next Wave: Infrastructure for Reality: Leverage crypto as a backend for innovative solutions to real-world problems, targeting broader, non-crypto native audiences.
