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AI Podcasts

August 4, 2025

Dwarkesh Patel and Noah Smith on AGI and the Economy

a16z

AI
Key Takeaways:
  1. Redefine AGI from Consciousness to Commerce. Forget Turing tests. The real benchmark for AGI is its ability to automate ~95% of white-collar work. The biggest missing piece isn't reasoning, but the capacity for continuous, on-the-job learning.
  2. Prepare for an Economic Singularity. Post-AGI growth won't be an incremental bump; it will be an explosive shift to 20%+ annual growth, driven by infinitely scalable AI labor. The bottleneck won't be human demand but the ambitions of the agents controlling the AI.
  3. The AGI Race Is More Industrial Revolution than Cold War. AGI is not a single bomb but a transformative process. The key risk isn't one nation nuking another, but advanced AIs playing nations against each other, much like the East India Company did in India.
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August 4, 2025

Micaela Bazo & Pedro Penna: AI, Drug Discovery, Decentralized Science, Behavioral Medicine | Ep 55

Ventura Labs

AI
Key Takeaways:
  1. Decentralize R&D for Efficiency. Using token-incentivized networks like Bittensor radically cuts costs and accelerates the initial drug discovery phase by tapping a competitive, global talent pool.
  2. Go Upstream for Bigger Wins. Targeting root "behavioral" causes of disease instead of just symptoms creates drugs with multi-condition applications, unlocking massive, previously unseen market potential.
  3. Innovate on Existing Rails. The fastest path to impact is by building on proven systems. Focusing on small molecules and using industry-standard validation partners creates a practical bridge between the worlds of crypto and traditional pharma.
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August 1, 2025

Will Market Euphoria Cool Off In August? | Weekly Round-Up

Forward Guidance

AI
Key Takeaways:
  1. Stagflation is Here: The Fed is poised to cut rates into rising inflation, an unorthodox move that signals how boxed-in monetary policy has become.
  2. The Two-Tiered Economy is Real: Capital is flowing to the "productive frontiers" of AI and tech, while legacy industries and the un-invested class get crushed. Policy is exacerbating this divide.
  3. Be Tactical, but Bet on the Ponzi: Expect a choppy August as euphoria cools. The long-term game, however, remains the same: bet on the assets that benefit from a global flight out of failing fiat and into productive, scarce technologies.
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August 1, 2025

MCP vs Browser Agents and Moving Beyond Crypto in the AI Space

Trillion Agents

AI
Key Takeaways:
  1. Crypto Is a Niche, Not a Foundation. AI builders are actively scrubbing crypto references from their branding to close enterprise deals. The market has decided: for now, crypto’s role is a payment rail, not the core agent stack.
  2. Bet on Native Protocols, Not Browsers. Browser-based agents are a dead end. The future belongs to agent-native protocols like MCP that enable efficient, bidirectional communication, mirroring the shift from mobile web to native apps.
  3. The AI Race Is a Power Race. The real bottleneck for AGI isn't just chips; it's energy. China's massive infrastructure build-out poses a strategic challenge to the West, which is betting on innovation in nuclear to keep pace. The future of AI may be decided by who can build power plants the fastest.
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July 31, 2025

How Distributed Compute Could Solve AI's Energy Crisis, w/ the CEO of Akash

The People's AI

AI
Key Takeaways:
  1. Energy is the New Scarcity. The race for AI supremacy is a race for power. Platforms like Akash that efficiently harness distributed, underutilized energy offer the only scalable alternative to the centralized model's impending energy crisis.
  2. The Tech is Maturing Rapidly. Asynchronous training and ZK-proofs (championed by projects like Jensen) are making permissionless global compute networks a reality. The performance gap with centralized systems is closing fast.
  3. The Mainstream is Buying In. A confluence of academic acceptance (at conferences like ICML) and favorable government policy (the White House's pro-open-source stance) is creating powerful tailwinds. The narrative has shifted from if decentralized AI is possible to how it will be implemented.
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July 31, 2025

The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)

Latent Space

AI
Key Takeaways:
  1. RLVR is the New SOTA for Solvable Problems: For tasks with clear right answers (code, math), RLVR is the state-of-the-art training method. The community is focused on scaling it, while RLHF remains the domain of fuzzy, human-preference problems.
  2. The Future is Search-Driven: GPT-4o’s heavy reliance on search is not a bug; it’s a feature. The hardest problem is no longer giving models tools, but training them to learn when to use them.
  3. Agents Need More Than Skills: The next leap in AI requires training for strategy, abstraction, and calibration. The goal is an AI that doesn’t just answer questions but efficiently plans its own work without wasting compute.
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July 31, 2025

China Open-Source, Compute Arms Race, Reordering Global Trade | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. China's Open-Source Models are Winning on Price & Performance. Chinese models offer ~90% of the intelligence of top US proprietary models for a fraction of the cost, driving massive global adoption and threatening to commoditize the model layer. An American open-source champion is desperately needed to compete.
  2. The "Cost is No Object" Compute Buildout is Reshaping the Market. A handful of private companies are spending at a loss to capture market share, fueled by VC. This creates a "sport of kings" dynamic that public companies can't match and makes pick-and-shovel players like Nvidia the biggest winners.
  3. The US Tariff Strategy is Working. Contrary to consensus, the administration's tariff gambit has secured favorable trade deals with the EU and Japan, generating hundreds of billions in revenue without causing significant consumer inflation, and setting the stage for a major renegotiation with China.
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July 31, 2025

Health Tech Founders: The Future of Care Is Personalized, Proactive—and AI-Powered

a16z

AI
Key Takeaways:
  1. Biology is the ultimate API for AI. The most impactful AI will be fed not just digital data but real-world biological signals. Companies are building the infrastructure to bring a user's biology online, turning abstract health data into a constant, actionable feed.
  2. Engagement metrics are being rewritten. Forget Daily Active Users. The new model is "intense, intentional engagement" during periods of need. Growth is a function of trust and real-world impact, where the best champions are users who have been genuinely helped.
  3. AI's role is augmentation, not automation. The goal isn't to replace doctors or therapists but to empower them. By translating noise into signal, AI lets human experts skip the data-sifting and focus on what they do best: solving problems.
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July 30, 2025

AI Content and the War for Your Attention

a16z

AI
Key Takeaways:
  1. AI is an attention-polluting machine. The primary challenge for social platforms will soon be managing the tidal wave of AI-generated "slop" designed to hijack algorithms, which risks alienating users entirely.
  2. The future of social is private. The psychological burden of being a micro-celebrity in a digital panopticon is pushing users away from public feeds and into smaller, trusted, and often monetized group chats.
  3. Attention mining’s endgame is total immersion. With phones saturated, the commercial logic of adtech demands new frontiers. VR is the path to monetizing waking hours, and Neuralink is the one to monetize dreams.
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Crypto Podcasts

October 30, 2025

Hivemind: Crypto's Leverage Hangover, Hyperliquid's Resurgance & What's Next for Markets?

Empire

Crypto
Key Takeaways:
  1. Survive, Then Thrive. After massive liquidations, the strongest assets and narratives (e.g., privacy plays like Zcash) recover first. Focus capital on names showing relative strength post-wipeout, as they are the first to capture returning liquidity.
  2. Revenue is the New Narrative. The game has changed. The market now demands clear revenue streams and legal structures that align token holders with protocol success. Valueless governance tokens are out; tokens tied to real business operations are in.
  3. On-Chain TradFi is Here. Platforms like Hyperliquid are successfully bringing assets like the NASDAQ on-chain, proving crypto-native demand for traditional markets. This represents a major new frontier for DeFi protocols looking to capture volume.
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October 29, 2025

Deficits Are Forcing the Fed Back Into Expansion | Lyn Alden

Forward Guidance

Crypto
Key Takeaways:
  1. **Fiscal is the new Fed.** Government spending, not central bank policy, is the dominant force in the economy. Stop looking for a traditional recession; the deficit is the stimulus that won’t quit.
  2. **The Fed is re-opening the liquidity spigot.** The era of Quantitative Tightening is over. A gradual but persistent expansion of the Fed's balance sheet is coming, which will provide a tailwind for assets.
  3. **Own scarce assets.** The long-term debasement of fiat currency is the default path. Alden remains constructive on Bitcoin, viewing its current phase as a prelude to a significant move higher in the coming years.
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October 28, 2025

Hash Rate - Ep 140 - The New Crucible Bittensor Wallet

Hash Rate pod - Bittensor $TAO & Subnets

Crypto
Key Takeaways:
  1. Security Is No Longer an Afterthought: The Crucible Wallet’s native Ledger integration provides the first hardware-secured, consumer-friendly way to manage TAO and subnet tokens, addressing a major security gap in the ecosystem.
  2. Automated Strategy Beats Day Trading: The "Staking to Core Alpha" feature offers a powerful tool that automatically reinvests yield into a customizable portfolio of subnets, saving users from the overwhelming task of constantly researching and reallocating assets.
  3. Capital Flow is King: The wallet's primary mission is to redirect staked TAO from the root network into deserving subnets, providing them with the capital needed to grow and achieve commercial success, which in turn strengthens the entire Bittensor network.
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October 28, 2025

How Crypto Neobanks Work: Frax, Cards, and Visa’s Role

Bankless

Crypto
Key Takeaways:
  1. The Real Metric Is GDP, Not Volume. A million dollars in daily card spending on real-world goods is a far more powerful signal of adoption than hundreds of millions in AMM swap volume. Watch the growth in real economic activity, not just on-chain shuffling.
  2. Infrastructure Is the Bottleneck. The race isn't just to launch another neobank; it's to build the underlying pipes. Protocols like Frax that power multiple stablecoins and neobanks are positioned to capture value from the entire ecosystem's growth.
  3. The End Game Is a Parallel Financial System. Crypto neobanks are the final link needed to close the economic loop. They enable a world where a user can save, earn yield, and spend entirely on-chain, making the concept of a bank account obsolete.
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October 28, 2025

LIVE: EQUITY PERPS, MEGAETH SALE, CRYPTO INTO EOY | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. Verticalize or Die. Protocols are aggressively bundling services to capture value and own the user experience. Standalone products are at risk of being outcompeted or acquired cheaply, as seen with Pump's acquisition of Padre.
  2. The Middle-Ground ICO is Hot. Highly anticipated projects like MegaETH are finding success with public sales that sit between illiquid private rounds and expensive public listings. For investors with capital, these offer a compelling risk/reward profile.
  3. Performance Trumps Purity. The debate is shifting. While credible neutrality is a good marketing angle, the rise of high-performance chains like Hyperliquid suggests users and capital will flow to the best product, regardless of its decentralization score.
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October 27, 2025

Why Every Major App Will Issue Their Own Stablecoin - m0 CEO

The Rollup

Crypto
Key Takeaways:
  1. Every App is a Future Fintech: Major applications will become their own central banks, issuing native stablecoins to control their financial rails, capture yield, and eliminate the platform risk inherent in relying on third-party issuers.
  2. Infrastructure, Not Brands, is the Real Game: The battle isn't over which stablecoin brand wins, but who builds the underlying rails that make a fragmented ecosystem of thousands of dollars feel like one seamless, interoperable network.
  3. The Stablecoin Market is Just Getting Started: Today's ~$300 billion stablecoin float is a "ridiculously small number." Expect a 100x expansion as money migrates from legacy bank ledgers to programmable, on-chain infrastructure.
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