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AI Podcasts

December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Pre-Training is the New Frontier: The next leap in AI capabilities, particularly for agentic systems, will come from fundamental advancements in pre-training, not just post-training tweaks.
  2. Builders & Investors: Focus on teams rethinking loss objectives, curating high-quality reasoning data, and developing dynamic benchmarks for agentic capabilities. Be wary of "agentic" claims that lack foundational pre-training innovation.
  3. The "So What?": Over the next 6-12 months, expect a push for new benchmarks and data strategies that explicitly train models for multi-step planning, long-form reasoning, and error recovery, moving beyond simple next-token prediction.
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December 16, 2025

What We Learned Deploying AI within Bloomberg’s Engineering Organization – Lei Zhang, Bloomberg

AI Engineer

AI
Key Takeaways:
  1. Strategic Implication: AI fundamentally changes the economics of software development. Organizations must re-evaluate what constitutes "high-quality" engineering and adapt their processes.
  2. Builder/Investor Note: Prioritize platforms that provide guardrails and guidance for AI tool usage, focusing on deterministic verification and robust testing. Uncontrolled AI deployment risks technical debt.
  3. The "So What?": The next 6-12 months will see a bifurcation: companies that strategically integrate AI into their engineering culture and platforms will gain significant efficiency, while those that don't will struggle with quality and adoption.
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December 16, 2025

Your Support Team Should Ship Code – Lisa Orr, Zapier

AI Engineer

AI
Key Takeaways:
  1. Workflow Automation is the New Frontier: The real value of AI in developer tools comes from orchestrating entire workflows, not just individual point solutions.
  2. Embed for Adoption: Tools must integrate seamlessly into existing workflows and IDEs (like Cursor) to achieve high usage.
  3. Support as a Code-Shipping Powerhouse: Empowering non-traditional roles with AI-driven code generation leverages their unique, real-time context, creating significant operational leverage.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Semantic Shift: The future of AI in code moves from text generation to deep semantic understanding and execution simulation.
  2. Builder Opportunity: Develop next-generation debugging tools and code agents that leverage internal simulation for faster, more efficient development cycles.
  3. Investor Focus: Prioritize models and platforms that demonstrate explicit execution modeling, as this capability will redefine software development and create new market leaders.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Infrastructure Shift: AI-driven kernel optimization addresses a critical bottleneck in scaling AI compute, enabling more efficient use of diverse hardware.
  2. Builder/Investor Note: Focus on solutions with robust, hardware-verified performance metrics and a clear human-in-the-loop strategy. AI is a powerful tool for automating optimization, not a magic bullet for novel algorithmic breakthroughs.
  3. The "So What?": This technology frees expert engineers from tedious optimization, allowing them to focus on higher-level research and truly innovative algorithmic design, accelerating the pace of AI development in the next 6-12 months.
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December 16, 2025

Finding The 1% of Stocks That Matter | Henry Ellenbogen Interview

Invest Like The Best

AI
Key Takeaways:
  1. Strategic Implication: The era of "free money" inflated the number of perceived compounders; a return to positive real rates demands a sharper focus on businesses demonstrating genuine financial discipline and competitive advantage.
  2. Builder/Investor Note: Seek out "Act 2" entrepreneurs and companies that can leverage AI to transform existing physical or IP-based advantages, not just create new AI products. Be prepared to buy more when market sentiment turns negative on strong businesses.
  3. The "So What?": The next 6-12 months will differentiate companies that merely adopt AI from those that strategically integrate it to build durable, uncatchable cost and distribution advantages.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. The Future of Policing is Intelligent: Integrating AI, drones, and smart cameras creates a precise, accountable, and safer policing model for both officers and communities.
  2. Invest in the "How": Builders and investors should focus on technologies that enhance certainty of capture, streamline judicial processes, and support public-private partnerships to modernize urban safety infrastructure.
  3. Safety Fuels Mobility: Eliminating crime is not just about law enforcement; it's about restoring the fundamental safety required for economic mobility and a functional society.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade's value will accrue to those building foundational AI infrastructure and the "invisible layers" that connect intelligent systems.
  2. Builder/Investor Note: Focus capital and talent on core AI models, specialized domain intelligence, and the underlying computational fabric. Superficial applications risk rapid commoditization.
  3. The So What?: This is the defining period for the architecture of global intelligence. Participation now determines future influence and relevance.
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December 16, 2025

⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security

Latent Space

AI
Key Takeaways:
  1. Strategic Shift: AI security must move beyond superficial guardrails to a full-stack, offensive red-teaming approach that accounts for the expanding attack surface of AI agents and their tool access.
  2. Builder/Investor Note: Builders should prioritize integrating offensive security early in development. Investors should be wary of "security theater" and favor solutions that embrace open-source collaboration and address the entire AI application stack.
  3. The "So What?": The accelerating pace of AI development means static security solutions will quickly become obsolete. Proactive, community-driven, and full-stack security research is essential for navigating the next 6-12 months of AI evolution.
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Crypto Podcasts

February 5, 2026

Alchemy CEO: Why AI Agents Need Crypto More Than Humans Do with Nikhil Viswanathan

The Rollup

Crypto
Key Takeaways:
  1. The convergence of AI and crypto is not just a technological trend; it's a foundational shift towards a digital society where AI agents are first-class economic citizens.
  2. Build agent-native financial primitives. Focus on creating protocols and services that allow AI agents to autonomously transact, manage assets, and interact with digital property without human intervention.
  3. The question isn't if digital currency and AI agents will dominate, but when and how.
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February 4, 2026

The Robot Revolution Is Here: Warehouse Automation, Humanoids, and What Comes Next

The People's AI

Crypto
Key Takeaways:
  1. The AI-driven automation is not a sudden, generalist humanoid takeover, but a gradual, specialized deployment.
  2. Invest in or build solutions for industrial automation, logistics, and specialized service robotics (e.g., medical, waste management).
  3. The next 5-10 years will see significant, quiet growth in non-humanoid, task-specific robots transforming supply chains, manufacturing, and healthcare.
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February 4, 2026

The Dogecoin Community Might Sh**t me for Saying This...

The DCo Podcast

Crypto
Key Takeaways:
  1. The ongoing global distrust in centralized financial systems fuels a search for decentralized alternatives, yet the crypto market's focus on "store of value" assets like Bitcoin risks missing the original intent of a truly global, fair means of exchange, a gap Dogecoin aims to fill.
  2. Re-evaluate digital asset utility beyond speculative store-of-value narratives, considering projects actively pursuing frictionless, low-cost means of exchange.
  3. The long-term viability of decentralized finance hinges on its ability to deliver practical, everyday utility, not just investment returns. This means projects focused on transactional efficiency could gain significant ground in the coming 6-12 months.
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February 4, 2026

Quadrillions: Stablecoins: We’ve Only Just Begun | Mohamed Afifi

Empire

Crypto
Key Takeaways:
  1. Build infrastructure that simplifies blockchain complexity and stablecoin fragmentation for end-users and enterprises. This is where the next wave of value creation lies.
  2. The global financial system's slowness and cost are directly challenged by programmable stablecoins, moving them from speculative assets to essential, low-cost, high-speed infrastructure.
  3. Stablecoins are moving from a crypto-native tool to a core layer for global finance.
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February 3, 2026

Haonan Li on How Codex is Taking Over The $7 Trillion FX Market

The Rollup

Crypto
Key Takeaways:
  1. As global economies grapple with inflation and inefficient financial systems, capital seeks refuge and utility in digital assets. Onchain FX provides a direct, cost-effective escape route, bypassing legacy intermediaries and offering a superior alternative for cross-border value transfer.
  2. Builders should focus on creating core financial primitives like onchain FX that solve real-world problems with superior economics, rather than chasing speculative narratives or token-driven vanity metrics.
  3. The next 6-12 months will see a continued acceleration of capital into crypto-native financial rails, particularly in emerging markets. Investors and builders should position themselves to capitalize on the structural cost advantages and network effects of onchain FX, which is poised to become a default market for many currency pairs.
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February 4, 2026

Stablecoins Hit $10T Monthly Volume, MetaMask Launches Tokenized Stocks & Galaxy Posts $482M Loss.

The Rollup

Crypto
Key Takeaways:
  1. The "Neo Finance" paradigm is solidifying, blending TradFi assets with DeFi's capital efficiency and transparency. This shift is not just about crypto, but about the future of all finance, with AI agents as a new class of economic actors.
  2. Invest in infrastructure and applications that bridge TradFi and DeFi, focusing on tokenized real-world assets and secure, high-yield stablecoin products. Prioritize platforms offering transparent, risk-managed yield, as institutional capital will flow there.
  3. The market's current volatility masks a profound structural transformation. Builders and investors who focus on creating seamless, capital-efficient, and AI-native financial products will capture the next wave of value, as digital assets become the default for both humans and machines.
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