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AI Podcasts

December 20, 2025

Are AI Benchmarks Telling The Full Story? [SPONSORED]

Machine Learning Street Talk

AI
Key Takeaways:
  1. Strategic Shift: The market will increasingly demand AI models evaluated on human-centric metrics, not just technical benchmarks. Companies prioritizing user experience and safety will gain a competitive edge.
  2. Builder/Investor Note: Investigate companies developing or utilizing advanced, demographically representative human evaluation frameworks. These are crucial for building defensible, user-aligned AI products.
  3. The "So What?": Over the next 6-12 months, expect a growing focus on AI safety, ethical alignment, and nuanced human preference data. The "Wild West" of AI evaluation is ending, paving the way for more robust, trustworthy systems.
See full notes
December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Strategic Implication: The next frontier in AI is agentic, and progress hinges on fundamental pre-training innovation, not just post-training optimizations.
  2. Builder/Investor Note: Focus on teams with deep experience in scaling and debugging large models, as this is a high-capital, high-risk endeavor. Builders should prioritize developing new benchmarks for agentic capabilities.
  3. The "So What?": The industry needs to move beyond next-token prediction and static benchmarks to unlock truly capable, self-correcting AI agents in the next 6-12 months.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Shift in AI Development: The focus moves from syntax-aware code generation to execution-aware reasoning, enabling more robust and intelligent code agents.
  2. Builder/Investor Note: Prioritize tools and platforms that support explicit execution modeling and highly asynchronous, high-throughput RL training for agentic systems.
  3. The "So What?": AI that can simulate complex systems internally will drastically reduce development and testing costs, accelerating innovation in software and distributed systems over the next 6-12 months.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI-driven kernel generation is not replacing human genius but augmenting it, allowing experts to focus on novel breakthroughs while AI automates the application of known optimizations across a complex hardware landscape.
  2. Builder/Investor Note: Focus on robust validation and hardware-in-the-loop systems. Claims of "AI inventing new algorithms" in this domain are premature. The real value is in automating the "bag of tricks" for heterogeneous compute.
  3. The "So What?": This technology is critical for scaling agentic AI workloads. Expect significant investment in tools that abstract hardware complexity and enable efficient, automated optimization, driving down the cost of AI inference in the next 6-12 months.
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December 18, 2025

AI Consulting in Practice – NLW, Super ai

AI Engineer

AI
Key Takeaways:
  1. The Agent Economy is Here: Enterprises are moving past pilots with AI agents. Builders should focus on orchestration layers and human-agent interaction design.
  2. ROI Measurement is the Next Frontier: Investors should look for solutions that help organizations accurately track and attribute AI value beyond traditional metrics.
  3. Strategic AI, Not Spot Solutions: The biggest wins come from systematic, cross-organizational AI strategies that target new capabilities and revenue growth, not just incremental time savings.
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December 18, 2025

How to build an AI native company (even if your company is 50 years old) – Dan Shipper, Every

AI Engineer

AI
Key Takeaways:
  1. The 100% AI adoption threshold is a step-function change, not incremental. Companies that commit fully will outpace those with partial integration.
  2. Builders should prioritize "compounding engineering" by codifying knowledge into reusable prompts. This builds an organizational memory that accelerates future development exponentially.
  3. Re-evaluate team structures and roles. Single engineers can own complex products, and even technical managers can contribute code, shifting how organizations operate.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. Effective crime reduction requires a shift from reactive punishment to proactive, intelligence-driven deterrence, making it highly probable for criminals to be caught.
  2. The market for AI-powered public safety technology, particularly solutions that integrate data for precision and accountability, presents a significant opportunity. Public-private partnerships are a key funding mechanism.
  3. Over the next 6-12 months, expect to see more cities adopt advanced surveillance and AI tools, driven by private funding, as they seek to improve safety and address staffing shortages without resorting to ineffective, broad-stroke policies.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade will be defined by who builds the core infrastructure for intelligence. This is where the most significant value and influence will accrue.
  2. Builder/Investor Note: Direct capital and talent towards foundational AI components—chips, models, and interoperable systems. Avoid the temptation to only build at the application layer.
  3. The So What?: The window for shaping the future of intelligence is now. Engage in the deepest, most complex challenges to secure a footprint in this new era.
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December 18, 2025

The EU and the not-so-simple macroeconomics of AI – Luis Garicano

Epoch AI

AI
Key Takeaways:
  1. Strategic Implication: The global AI race is a zero-sum game for foundational models. Europe's best strategy is a "smart second mover" approach, focusing on the implementation layer by ensuring interoperability and data portability.
  2. Builder/Investor Note: Invest in AI that achieves true autonomy and enhances expert productivity. Be wary of markets stifled by over-regulation, which can impede AI adoption and growth.
  3. The "So What?": Europe faces a critical juncture. Without embracing AI-driven growth, its demographic and debt problems will worsen, leading to higher interest rates without the corresponding economic expansion.
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Crypto Podcasts

July 12, 2025

How PumpDotFun Could Capture The Intersection Of Content, Crypto And Gaming

Empire

Crypto
Key Takeaways
  1. The New Media Blueprint: The winning strategy is a blend of long-form, authentic live streams and hyper-optimized social clips. Platforms that natively support this will win.
  2. Content, Not Just Coins: To achieve longevity, Pump.fun must evolve beyond a pure trading terminal. It needs to give users a reason to stay that isn't just watching a chart.
  3. Finance Is Entertainment: For a new generation, trading is a competitive social game. The most successful platforms will be those that embrace this "leaderboard" mentality and build entertainment-first financial experiences.
See full notes
July 12, 2025

Phantom Chooses Hyperliquid for Perps | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. Distribution is the New Moat: Wallets like Phantom are becoming aggregator kings. By integrating the best backend protocol (Hyperliquid), they can dominate user flow and marginalize competing applications.
  2. Infrastructure Eats Applications: Hyperliquid’s success stems from its focus on being a permissionless infrastructure layer, not just an app. It outsources distribution to capture flow from the entire crypto ecosystem, a model that standalone DEXes will find nearly impossible to compete with.
  3. Mobile is Crypto’s Next Frontier: Phantom’s mobile-only perp launch is a bet that the next wave of users will prioritize convenience and native experiences. Its initial success signals a critical shift in how DeFi applications must be designed and delivered.
See full notes
July 11, 2025

Winners & Losers From PUMP’S ICO With Santi & Rob Hadick | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. **App-Chains Are The New End Game.** Successful apps are now launching their own sovereign chains, posing an existential threat to host L1s like Solana. The most valuable real estate is direct user ownership, not just building on the fastest chain.
  2. **Trading Is The New Gaming.** For Gen Z, speculation is a primary form of entertainment. Platforms that successfully blend content with financialization are tapping into a powerful cultural current that moves far beyond traditional "investing" narratives.
  3. **Winners Buy, They Don't Build.** The crypto M&A market is hot. Well-capitalized players (e.g., Monad buying Portal) are acquiring talent and tech to build full-stack platforms, while many 2022-era startups are prime acquisition targets.
See full notes
July 11, 2025

Bitcoin All-Time-High, Is ETH Next?

Bankless

Crypto
Key Takeaways:
  1. A perfect storm of narrative, structural demand, and historical precedent is building for Ether, but its price has yet to reflect this reality, and the underlying technical work remains critical.
  2. The ETH Coiled Spring: A massive disconnect exists between euphoric pro-ETH sentiment—driven by treasury buys and mainstream narratives—and its lagging price. History suggests when ETH moves, it will be explosive, leaving sideline-sitters behind.
  3. Corporate Treasuries are the New Demand Sink: A new class of publicly traded "ETH Treasury" companies is in an arms race to acquire ETH, creating a structural demand shock that could absorb all new issuance and initiate a powerful positive feedback loop.
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July 10, 2025

The 8% Debasement Trap Killing Your Wealth

Forward Guidance

Crypto
Key Takeaways:
  1. Your Portfolio Is Bleeding. Unless concentrated in tech (NASDAQ) and crypto (Bitcoin, ETH), your purchasing power is eroding by 8% annually. Assets like the S&P 500 or gold are merely treading water against this relentless tide.
  2. Diversification Is a Wealth Destroyer. In a world dominated by a single macro factor—currency debasement—spreading capital across underperforming assets guarantees a loss of real value. A concentrated portfolio is now the only logical strategy.
  3. Tech Is Winning, But Crypto Is Lapping It. While the NASDAQ beats debasement, it's losing badly to crypto. The NASDAQ is down over 99% against Bitcoin since 2012, making crypto the apex asset for accumulating real wealth.
See full notes
July 9, 2025

Crypto Experts Explain Stablecoins & the Future Financial System w/ Ali Yahya & Arianna Simpson

a16z

Crypto
Key Takeaways:
  1. Stablecoins are the Trojan Horse. They are crypto's killer app, driving real-world utility and legitimizing the space for institutions and mainstream users by solving tangible financial inefficiencies.
  2. Crypto is AI’s Essential Counterbalance. As AI centralizes power and blurs reality, crypto provides the critical infrastructure for decentralization, authentication, and new economic models for creators.
  3. The Regulatory Winter is Over. A friendlier U.S. political climate has opened the door for a new wave of crypto innovation. For investors and builders, this is the signal that it's time to build.
See full notes