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AI Podcasts

August 4, 2025

Dwarkesh Patel and Noah Smith on AGI and the Economy

a16z

AI
Key Takeaways:
  1. Redefine AGI from Consciousness to Commerce. Forget Turing tests. The real benchmark for AGI is its ability to automate ~95% of white-collar work. The biggest missing piece isn't reasoning, but the capacity for continuous, on-the-job learning.
  2. Prepare for an Economic Singularity. Post-AGI growth won't be an incremental bump; it will be an explosive shift to 20%+ annual growth, driven by infinitely scalable AI labor. The bottleneck won't be human demand but the ambitions of the agents controlling the AI.
  3. The AGI Race Is More Industrial Revolution than Cold War. AGI is not a single bomb but a transformative process. The key risk isn't one nation nuking another, but advanced AIs playing nations against each other, much like the East India Company did in India.
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August 4, 2025

Micaela Bazo & Pedro Penna: AI, Drug Discovery, Decentralized Science, Behavioral Medicine | Ep 55

Ventura Labs

AI
Key Takeaways:
  1. Decentralize R&D for Efficiency. Using token-incentivized networks like Bittensor radically cuts costs and accelerates the initial drug discovery phase by tapping a competitive, global talent pool.
  2. Go Upstream for Bigger Wins. Targeting root "behavioral" causes of disease instead of just symptoms creates drugs with multi-condition applications, unlocking massive, previously unseen market potential.
  3. Innovate on Existing Rails. The fastest path to impact is by building on proven systems. Focusing on small molecules and using industry-standard validation partners creates a practical bridge between the worlds of crypto and traditional pharma.
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August 1, 2025

Will Market Euphoria Cool Off In August? | Weekly Round-Up

Forward Guidance

AI
Key Takeaways:
  1. Stagflation is Here: The Fed is poised to cut rates into rising inflation, an unorthodox move that signals how boxed-in monetary policy has become.
  2. The Two-Tiered Economy is Real: Capital is flowing to the "productive frontiers" of AI and tech, while legacy industries and the un-invested class get crushed. Policy is exacerbating this divide.
  3. Be Tactical, but Bet on the Ponzi: Expect a choppy August as euphoria cools. The long-term game, however, remains the same: bet on the assets that benefit from a global flight out of failing fiat and into productive, scarce technologies.
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August 1, 2025

MCP vs Browser Agents and Moving Beyond Crypto in the AI Space

Trillion Agents

AI
Key Takeaways:
  1. Crypto Is a Niche, Not a Foundation. AI builders are actively scrubbing crypto references from their branding to close enterprise deals. The market has decided: for now, crypto’s role is a payment rail, not the core agent stack.
  2. Bet on Native Protocols, Not Browsers. Browser-based agents are a dead end. The future belongs to agent-native protocols like MCP that enable efficient, bidirectional communication, mirroring the shift from mobile web to native apps.
  3. The AI Race Is a Power Race. The real bottleneck for AGI isn't just chips; it's energy. China's massive infrastructure build-out poses a strategic challenge to the West, which is betting on innovation in nuclear to keep pace. The future of AI may be decided by who can build power plants the fastest.
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July 31, 2025

How Distributed Compute Could Solve AI's Energy Crisis, w/ the CEO of Akash

The People's AI

AI
Key Takeaways:
  1. Energy is the New Scarcity. The race for AI supremacy is a race for power. Platforms like Akash that efficiently harness distributed, underutilized energy offer the only scalable alternative to the centralized model's impending energy crisis.
  2. The Tech is Maturing Rapidly. Asynchronous training and ZK-proofs (championed by projects like Jensen) are making permissionless global compute networks a reality. The performance gap with centralized systems is closing fast.
  3. The Mainstream is Buying In. A confluence of academic acceptance (at conferences like ICML) and favorable government policy (the White House's pro-open-source stance) is creating powerful tailwinds. The narrative has shifted from if decentralized AI is possible to how it will be implemented.
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July 31, 2025

The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)

Latent Space

AI
Key Takeaways:
  1. RLVR is the New SOTA for Solvable Problems: For tasks with clear right answers (code, math), RLVR is the state-of-the-art training method. The community is focused on scaling it, while RLHF remains the domain of fuzzy, human-preference problems.
  2. The Future is Search-Driven: GPT-4o’s heavy reliance on search is not a bug; it’s a feature. The hardest problem is no longer giving models tools, but training them to learn when to use them.
  3. Agents Need More Than Skills: The next leap in AI requires training for strategy, abstraction, and calibration. The goal is an AI that doesn’t just answer questions but efficiently plans its own work without wasting compute.
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July 31, 2025

China Open-Source, Compute Arms Race, Reordering Global Trade | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. China's Open-Source Models are Winning on Price & Performance. Chinese models offer ~90% of the intelligence of top US proprietary models for a fraction of the cost, driving massive global adoption and threatening to commoditize the model layer. An American open-source champion is desperately needed to compete.
  2. The "Cost is No Object" Compute Buildout is Reshaping the Market. A handful of private companies are spending at a loss to capture market share, fueled by VC. This creates a "sport of kings" dynamic that public companies can't match and makes pick-and-shovel players like Nvidia the biggest winners.
  3. The US Tariff Strategy is Working. Contrary to consensus, the administration's tariff gambit has secured favorable trade deals with the EU and Japan, generating hundreds of billions in revenue without causing significant consumer inflation, and setting the stage for a major renegotiation with China.
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July 31, 2025

Health Tech Founders: The Future of Care Is Personalized, Proactive—and AI-Powered

a16z

AI
Key Takeaways:
  1. Biology is the ultimate API for AI. The most impactful AI will be fed not just digital data but real-world biological signals. Companies are building the infrastructure to bring a user's biology online, turning abstract health data into a constant, actionable feed.
  2. Engagement metrics are being rewritten. Forget Daily Active Users. The new model is "intense, intentional engagement" during periods of need. Growth is a function of trust and real-world impact, where the best champions are users who have been genuinely helped.
  3. AI's role is augmentation, not automation. The goal isn't to replace doctors or therapists but to empower them. By translating noise into signal, AI lets human experts skip the data-sifting and focus on what they do best: solving problems.
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July 30, 2025

AI Content and the War for Your Attention

a16z

AI
Key Takeaways:
  1. AI is an attention-polluting machine. The primary challenge for social platforms will soon be managing the tidal wave of AI-generated "slop" designed to hijack algorithms, which risks alienating users entirely.
  2. The future of social is private. The psychological burden of being a micro-celebrity in a digital panopticon is pushing users away from public feeds and into smaller, trusted, and often monetized group chats.
  3. Attention mining’s endgame is total immersion. With phones saturated, the commercial logic of adtech demands new frontiers. VR is the path to monetizing waking hours, and Neuralink is the one to monetize dreams.
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Crypto Podcasts

November 28, 2025

Can ‘Choose Rich’ Nick Create the Barstool Sports of Crypto?

Unchained

Crypto
Key Takeaways:
  1. Weaponize cringe for distribution. The ‘Choose Rich Nick’ model proves that being the butt of the joke is a powerful growth hack. Manufacturing moments that invite mockery creates a viral loop of outrage and engagement that funnels attention to the core business.
  2. Authenticity is a liability. The most successful stunts are meticulously planned fabrications. From fake girlfriends to staged yacht expulsions, the goal isn't to be real but to create a compelling narrative that the internet can’t ignore.
  3. Success hinges on ambiguity. The content is designed to polarize. Its virality depends on a split audience: one half gets the joke and celebrates the performance, while the other half takes it at face value, fueling the outrage machine that drives impressions.
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November 28, 2025

Klarna Launches A Stablecoin, Hyperliquid Perps & The Prediction Market Wars | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. Fintech is the New On-Ramp. Giants like Klarna are adopting stablecoins for economic utility, not speculation. This signals a new wave of adoption driven by real-world efficiency gains.
  2. Re-evaluate Your Valuations. The massive valuation gap between a fintech like Klarna and an L1 like Solana forces a critical question: will value accrue to the rails or the businesses that use them to serve hundreds of millions of customers?
  3. Distribution is Undefeated. Robinhood’s move to sideline its partner Kalshi proves that owning the customer relationship is the ultimate moat, a crucial lesson for infrastructure projects reliant on third-party distribution.
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November 27, 2025

Anthony Sassano on Why This Cycle Isn’t Playing Out Like the Last Ones

Bankless

Crypto
Key Takeaways:
  1. The Old Playbooks Are Obsolete. This isn't your 2021 bull run. The four-year cycle is broken, institutional flows have altered market dynamics, and historical patterns are no longer reliable predictors of future performance.
  2. Ethereum Is Entering Hyper-Scale. A relentless upgrade cadence is simultaneously scaling both L1 (via gas limit increases) and L2s (via blob scaling), even before the ZK revolution delivers another 100x+ throughput boost to the mainnet.
  3. Adaptability Is the Ultimate Security. Existential threats like quantum computing are moving from science fiction to near-term reality. Ethereum's culture of continuous improvement is its greatest defense, while chains resistant to change face a brewing crisis.
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November 25, 2025

Closed my ETH Short ($578k Profit). What’s Next for Crypto?

Taiki Maeda

Crypto
Key Takeaways:
  1. **ETH is Overvalued and Avoidable.** Its fundamentals do not justify its sky-high valuation. View it as a flawed asset, not a mandatory portfolio holding for crypto investors.
  2. **Farm, Don't Trade.** The most reliable retail edge isn't trading, but airdrop farming. It allows you to acquire assets from overvalued launches without providing exit liquidity.
  3. **Cash is a Position.** In a market defined by negative reflexivity and dwindling liquidity, the winning strategy is capital preservation. Avoid the casino, raise cash, and wait for the market to present clear, undervalued opportunities.
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November 24, 2025

How to Trade Crypto Cycles with Raoul Pal

Empire

Crypto
Key Takeaways:
  1. Stop Obsessing Over the Halving. The four-year cycle is a narrative, not a driver. The real signal is the macro business cycle, driven by debt refinancing and central bank liquidity. Track the ISM index: historically, buying below 50 and selling above 57 has been a winning strategy.
  2. Invest in Networks, Not Spreadsheets. Value crypto protocols based on network effects (active users and transaction value), not discounted cash flows. The long-term bet is on the growth of the network itself, as this is where wealth has compounded most dramatically.
  3. Survive to Compound. Structure your portfolio to withstand volatility. Have external cash flow so you’re never a forced seller, and take "lifestyle chips" off the table during rallies to manage psychological stress. Drawdowns are a feature, not a bug—use them to add to your long-term positions.
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November 24, 2025

The Real Crypto Cycle: What Happens When Global Liquidity Peaks

Bankless

Crypto
Key Takeaways:
  1. **The Trend is Up, The Cycle is Peaking.** Relentless government spending ensures long-term monetary inflation, making assets like Bitcoin and gold essential core holdings. However, the 65-month cycle is nearing its peak, signaling a time to reduce risk and prepare for turbulence.
  2. **Own Both Sides of the Capital War.** The future is a bipolar monetary world. An optimal portfolio holds both Bitcoin (representing the US digital collateral system) and gold (representing China’s hard money strategy) to hedge against persistent inflation from both sides.
  3. **Watch the Repo Market for the Spark.** The immediate flashing red light is in the repo markets, where interest rate spreads are blowing out. An unwind of leveraged positions here could be the catalyst that ends the current cycle, creating a prime buying opportunity for patient, long-term investors.
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