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AI Podcasts

December 12, 2025

Hard Won Lessons from Building Effective AI Coding Agents – Nik Pash, Cline

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: The competitive edge in AI agents is moving from clever architecture to superior model training data and robust RL environments.
  2. Builder/Investor Note: Prioritize raw model capability over complex agent stacks. Builders should contribute to open-source RL environments; investors should seek companies focused on generating and leveraging high-quality training data.
  3. The "So What?": The next 6-12 months will see a race to build and utilize real-world, outcome-driven benchmarks. Open initiatives like Client Bench could democratize model improvement and accelerate AI development significantly.
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December 11, 2025

The State of AI Code Quality: Hype vs Reality — Itamar Friedman, Qodo

AI Engineer

AI
Key Takeaways:
  1. Strategic Implication: The next frontier of AI in software isn't just *generating* code, but *governing* its quality. This shift will redefine competitive advantage.
  2. Builder/Investor Note: Prioritize investments in AI-powered quality gates, intelligent code review, and dynamic testing. For builders, feed your AI tools rich, comprehensive context. For investors, look for companies building these "picks and shovels."
  3. The "So What?": The promised 2x-10x productivity gains are real, but they won't come from raw code generation alone. The next 6-12 months will see a scramble to implement agentic, context-aware quality workflows to unlock AI's true potential across the SDLC.
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December 11, 2025

Can you prove AI ROI in Software Eng? (Stanford 120k Devs Study) – Yegor Denisov-Blanch, Stanford

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI ROI isn't about adoption, it's about intelligent adoption. The gap between top and bottom performers will widen based on measurement sophistication and codebase health.
  2. Builder/Investor Note: For builders, prioritize codebase hygiene and engineer training before or concurrently with AI rollout. For investors, scrutinize AI productivity claims; ask about code quality, rework rates, and specific measurement frameworks beyond simple usage.
  3. The "So What?": In the next 6-12 months, companies that master AI integration by focusing on quality, measurement, and environment will compound their gains, while those chasing superficial metrics risk significant tech debt and negative ROI.
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December 11, 2025

No Priors Ep. 143 | With ElevenLabs Co-Founder Mati Staniszewski

No Priors: AI, Machine Learning, Tech, & Startups

AI
Key Takeaways:
  1. Strategic Shift: The future of human-computer interaction is voice-first, moving from static content to dynamic, personalized, and agentic experiences.
  2. Builder/Investor Note: Defensibility in AI is increasingly found in deep product layers, specialized architectural breakthroughs (especially in audio), and robust ecosystems, not just raw model scale.
  3. The "So What?": Over the next 6-12 months, expect to see significant advancements in proactive AI agents, immersive media, and personalized education, with voice as the core interface.
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December 10, 2025

Nav Kumar: Trishool, AI Alignment, Subnet 23, Mechanistic Interpretability, Rogue LLMs | Ep. 75

Ventura Labs

AI
Key Takeaways:
  1. **Prioritize AI Safety Research:** Invest aggressively in understanding and mitigating AI risks to safeguard humanity against potential rogue LLMs.
  2. **Support Decentralized AI Alignment:** Champion decentralized platforms like Bit Tensor and initiatives like Trishool that promote open and transparent AI alignment research.
  3. **Embrace Mechanistic Interpretability:** Drive the development of tools that enable us to understand and control the internal workings of AI models, ensuring alignment with human values.
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December 10, 2025

The Unicorn Founder Who Delegated Everything.

a16z

AI
Key Takeaways:
  1. The AI-Delegation Revolution is Here: Start experimenting with AI tools like ChatGPT for delegation now. The future involves proactive machine assistants deeply integrated into your workflow.
  2. Builders & Investors: Focus on "How to Delegate": The biggest constraint isn't finding assistants, but teaching clients how to delegate effectively. Tools and services that educate delegators will win.
  3. Reclaim Your Ambition: By offloading the mundane, you free up mental bandwidth to think bigger, pursue more ambitious goals, and ultimately, control your most valuable asset: time.
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December 10, 2025

Everyone Needs an Assistant. Here’s Why.

a16z

AI
Key Takeaways:
  1. Embrace Delegation as a Foundational Skill: Whether you leverage AI or human support, mastering delegation is paramount for unlocking personal and professional potential.
  2. Prioritize Time Ownership: Recognize time as your most valuable asset and design your life and calendar around your highest goals.
  3. Start Small, Scale Intentionally: Begin with affordable AI tools and gradually incorporate human assistance as your budget and needs evolve, building trust and compounding leverage over time.
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December 8, 2025

Building The Chip That Could Unlock AGI | Naveen Rao

a16z

AI
Key Takeaways:
  1. **Embrace Analog:** Explore and invest in analog computing solutions to overcome the energy limitations of current digital AI systems.
  2. **Prioritize Causality:** Shift focus towards AI models that incorporate time and causality, potentially unlocking more advanced and human-like intelligence.
  3. **Support Hardware Innovation:** Invest in and foster startups like Unconventional AI that are tackling fundamental challenges in AI hardware.
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December 8, 2025

Why AI Will Have To Run On Blockchains

The DCo Podcast

AI
Key Takeaways:
  1. Blockchain is essential for AI to ensure censorship resistance and uninterrupted accessibility.
  2. Trustworthy AI agents require on-chain governance to manage assets securely and transparently.
  3. AI agents can drastically accelerate blockchain adoption and optimize corporate processes.
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Crypto Podcasts

December 17, 2025

Lark Davis: The Bull & Bear Thesis for Digital Assets

The Rollup

Crypto
Key Takeaways:
  1. Concentration is Key: Ruthlessly prune portfolios, focusing on assets with clear utility, user adoption, and robust value accrual mechanisms.
  2. Build for Revenue: For builders, design tokenomics that directly reward token holders with revenue or buybacks, moving beyond abstract governance.
  3. Macro Over Cycle: The Fed's liquidity injections and potential rate cuts could override historical crypto cycles, creating a unique market environment for the next 6-12 months.
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December 16, 2025

How Crypto Networks Are Racing to Be the TradFi Chain - Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Strategic Implication: The "Empire Strikes Back" is real, with TradFi giants building their own tokenized solutions and specialized chains, intensifying competition for public blockchains.
  2. Builder/Investor Note: Focus on infrastructure and applications that enable seamless movement of tokenized "money" between specialized chains. This interoperability is crucial for unlocking capital efficiency.
  3. The "So What?": Despite current market rotation into "value" assets, the long-term trend of institutional tokenization is accelerating. Regulatory clarity in the US will act as a significant accelerant, but competitive forces are already driving adoption.
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December 16, 2025

How Hylo Is Accelerating Solana DeFi In 2026 | Plish

Lightspeed

Crypto
Key Takeaways:
  1. Productive Stablecoins are Key: The transition from unproductive to productive stablecoins like hUSD is a significant catalyst for Solana DeFi growth, attracting capital by offering intrinsic yield.
  2. Builders, Simplify Leverage: Hylo's success with xSOL demonstrates the demand for simplified, liquidation-proof leverage products. Builders should focus on making complex DeFi primitives accessible through intuitive design.
  3. The X-Asset Frontier: Hylo's move into XBTC and other X-assets signals a broader trend: tokenizing leverage for diverse crypto assets will be a major growth driver for DeFi in the next 6-12 months.
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December 16, 2025

10 Crypto Predictions for 2026: $1M BTC, Wall Street Onchain & ETF Takeover

Bankless

Crypto
Key Takeaways:
  1. Strategic Implication: Crypto is transitioning from a niche, retail-driven asset class to a mainstream, institutionally-backed financial infrastructure. This shift will drive sustained growth, reduced volatility, and lower correlation with traditional assets.
  2. Builder/Investor Note: Re-evaluate crypto allocations, recognizing the shift from retail-driven cycles to institutional adoption. Explore diversified exposure beyond Bitcoin, including ETH, Solana, and high-quality DeFi tokens as their economic capture improves. The rise of on-chain vaults indicates demand for professional, diversified asset management strategies on-chain.
  3. The "So What?": The market is vastly underestimating the fundamental progress and institutional acceptance of crypto. The "suit coiners" are bullish for a reason, and their capital will reshape the landscape in 2026 and beyond.
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December 16, 2025

JPMorgan Goes Onchain as the Fed Cuts & Why Bitcoin Can’t Break Out - Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Institutional Inevitability: Major financial institutions will continue tokenizing traditional assets, creating a clear, low-risk entry point for TradFi into crypto.
  2. Builder Focus: Build infrastructure that bridges TradFi and crypto, or specialize in high-throughput retail solutions. Regulatory compliance and education are paramount.
  3. Market Patience: Expect continued pressure on high-beta crypto assets until a clear market shift occurs, likely requiring high-beta assets to become oversold and the "value" rally to top out.
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December 16, 2025

Visa Stablecoin Strategy, N3on Crashout, AXL Acquisition, JPMorgan MMF on Ethereum & Nexus x Rialo

The Rollup

Crypto
Key Takeaways:
  1. Strategic Implication: The future of crypto is increasingly defined by institutional adoption, driven by the need for verifiable, private, and compliant digital assets and systems.
  2. Builder/Investor Note: Focus on foundational technologies like ZK proofs and secure interoperability. Avoid speculative retail trends that lack long-term utility.
  3. The "So What?": The convergence of AI and blockchain will redefine trust. Builders who integrate ZKPs to authenticate AI outputs and ensure agent accountability will capture significant value in the next 6-12 months.
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