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AI Podcasts

August 4, 2025

Micaela Bazo & Pedro Penna: AI, Drug Discovery, Decentralized Science, Behavioral Medicine | Ep 55

Ventura Labs

AI
Key Takeaways:
  1. Decentralize R&D for Efficiency. Using token-incentivized networks like Bittensor radically cuts costs and accelerates the initial drug discovery phase by tapping a competitive, global talent pool.
  2. Go Upstream for Bigger Wins. Targeting root "behavioral" causes of disease instead of just symptoms creates drugs with multi-condition applications, unlocking massive, previously unseen market potential.
  3. Innovate on Existing Rails. The fastest path to impact is by building on proven systems. Focusing on small molecules and using industry-standard validation partners creates a practical bridge between the worlds of crypto and traditional pharma.
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August 4, 2025

Dwarkesh Patel and Noah Smith on AGI and the Economy

a16z

AI
Key Takeaways:
  1. Redefine AGI from Consciousness to Commerce. Forget Turing tests. The real benchmark for AGI is its ability to automate ~95% of white-collar work. The biggest missing piece isn't reasoning, but the capacity for continuous, on-the-job learning.
  2. Prepare for an Economic Singularity. Post-AGI growth won't be an incremental bump; it will be an explosive shift to 20%+ annual growth, driven by infinitely scalable AI labor. The bottleneck won't be human demand but the ambitions of the agents controlling the AI.
  3. The AGI Race Is More Industrial Revolution than Cold War. AGI is not a single bomb but a transformative process. The key risk isn't one nation nuking another, but advanced AIs playing nations against each other, much like the East India Company did in India.
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August 1, 2025

Will Market Euphoria Cool Off In August? | Weekly Round-Up

Forward Guidance

AI
Key Takeaways:
  1. Stagflation is Here: The Fed is poised to cut rates into rising inflation, an unorthodox move that signals how boxed-in monetary policy has become.
  2. The Two-Tiered Economy is Real: Capital is flowing to the "productive frontiers" of AI and tech, while legacy industries and the un-invested class get crushed. Policy is exacerbating this divide.
  3. Be Tactical, but Bet on the Ponzi: Expect a choppy August as euphoria cools. The long-term game, however, remains the same: bet on the assets that benefit from a global flight out of failing fiat and into productive, scarce technologies.
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August 1, 2025

MCP vs Browser Agents and Moving Beyond Crypto in the AI Space

Trillion Agents

AI
Key Takeaways:
  1. Crypto Is a Niche, Not a Foundation. AI builders are actively scrubbing crypto references from their branding to close enterprise deals. The market has decided: for now, crypto’s role is a payment rail, not the core agent stack.
  2. Bet on Native Protocols, Not Browsers. Browser-based agents are a dead end. The future belongs to agent-native protocols like MCP that enable efficient, bidirectional communication, mirroring the shift from mobile web to native apps.
  3. The AI Race Is a Power Race. The real bottleneck for AGI isn't just chips; it's energy. China's massive infrastructure build-out poses a strategic challenge to the West, which is betting on innovation in nuclear to keep pace. The future of AI may be decided by who can build power plants the fastest.
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July 31, 2025

How Distributed Compute Could Solve AI's Energy Crisis, w/ the CEO of Akash

The People's AI

AI
Key Takeaways:
  1. Energy is the New Scarcity. The race for AI supremacy is a race for power. Platforms like Akash that efficiently harness distributed, underutilized energy offer the only scalable alternative to the centralized model's impending energy crisis.
  2. The Tech is Maturing Rapidly. Asynchronous training and ZK-proofs (championed by projects like Jensen) are making permissionless global compute networks a reality. The performance gap with centralized systems is closing fast.
  3. The Mainstream is Buying In. A confluence of academic acceptance (at conferences like ICML) and favorable government policy (the White House's pro-open-source stance) is creating powerful tailwinds. The narrative has shifted from if decentralized AI is possible to how it will be implemented.
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July 31, 2025

Health Tech Founders: The Future of Care Is Personalized, Proactive—and AI-Powered

a16z

AI
Key Takeaways:
  1. Biology is the ultimate API for AI. The most impactful AI will be fed not just digital data but real-world biological signals. Companies are building the infrastructure to bring a user's biology online, turning abstract health data into a constant, actionable feed.
  2. Engagement metrics are being rewritten. Forget Daily Active Users. The new model is "intense, intentional engagement" during periods of need. Growth is a function of trust and real-world impact, where the best champions are users who have been genuinely helped.
  3. AI's role is augmentation, not automation. The goal isn't to replace doctors or therapists but to empower them. By translating noise into signal, AI lets human experts skip the data-sifting and focus on what they do best: solving problems.
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July 31, 2025

The RLVR Revolution — with Nathan Lambert (AI2, Interconnects.ai)

Latent Space

AI
Key Takeaways:
  1. RLVR is the New SOTA for Solvable Problems: For tasks with clear right answers (code, math), RLVR is the state-of-the-art training method. The community is focused on scaling it, while RLHF remains the domain of fuzzy, human-preference problems.
  2. The Future is Search-Driven: GPT-4o’s heavy reliance on search is not a bug; it’s a feature. The hardest problem is no longer giving models tools, but training them to learn when to use them.
  3. Agents Need More Than Skills: The next leap in AI requires training for strategy, abstraction, and calibration. The goal is an AI that doesn’t just answer questions but efficiently plans its own work without wasting compute.
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July 31, 2025

China Open-Source, Compute Arms Race, Reordering Global Trade | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. China's Open-Source Models are Winning on Price & Performance. Chinese models offer ~90% of the intelligence of top US proprietary models for a fraction of the cost, driving massive global adoption and threatening to commoditize the model layer. An American open-source champion is desperately needed to compete.
  2. The "Cost is No Object" Compute Buildout is Reshaping the Market. A handful of private companies are spending at a loss to capture market share, fueled by VC. This creates a "sport of kings" dynamic that public companies can't match and makes pick-and-shovel players like Nvidia the biggest winners.
  3. The US Tariff Strategy is Working. Contrary to consensus, the administration's tariff gambit has secured favorable trade deals with the EU and Japan, generating hundreds of billions in revenue without causing significant consumer inflation, and setting the stage for a major renegotiation with China.
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July 30, 2025

AI Content and the War for Your Attention

a16z

AI
Key Takeaways:
  1. AI is an attention-polluting machine. The primary challenge for social platforms will soon be managing the tidal wave of AI-generated "slop" designed to hijack algorithms, which risks alienating users entirely.
  2. The future of social is private. The psychological burden of being a micro-celebrity in a digital panopticon is pushing users away from public feeds and into smaller, trusted, and often monetized group chats.
  3. Attention mining’s endgame is total immersion. With phones saturated, the commercial logic of adtech demands new frontiers. VR is the path to monetizing waking hours, and Neuralink is the one to monetize dreams.
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Crypto Podcasts

December 18, 2025

Why Gen Z Will Turn Everything Into a Market | Threadguy

Bankless

Crypto
Key Takeaways:
  1. Strategic Implication: The lines between traditional finance, crypto, and cultural markets will blur. "Internet markets" will encompass everything, driven by attention and mimetics.
  2. Builder/Investor Note: Focus on platforms that facilitate permissionless market creation and enhance the "spectacle" of trading. User experience that feels as native as social media will capture Gen Z's capital.
  3. The "So What?": Crypto's open, liquid, and attention-driven nature makes it the ultimate infrastructure for this new financial paradigm. The next decade will see an explosion of internet asset trading, with crypto at its core.
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December 18, 2025

Solana’s Big Upgrade, Aave’s Civil War & the Problem With Token Value: Uneasy Money

Unchained

Crypto
Key Takeaways:
  1. Clarity is King: The industry needs clearer, legally defensible definitions of token holder rights and revenue accrual to build trust and sustainable value.
  2. Builder/Investor Note: Builders should prioritize explicit tokenomics and robust governance. Investors must scrutinize token rights beyond speculative narratives and be hyper-vigilant against social engineering scams.
  3. The "So What?": The next 6-12 months will test which projects can evolve beyond ambiguous structures to deliver tangible value and accountability, separating sustainable innovation from speculative chaos.
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December 18, 2025

🟦 Base Eco & Coinbase System Update Mega Stream

The Rollup

Crypto
Key Takeaways:
  1. Market Bifurcation: The crypto market is splitting. Protocols with strong FinTech distribution partnerships (the "DeFi mullets") will outpace those relying solely on crypto-native power users.
  2. Builder/Investor Note: Builders should prioritize Base App integration and AI-driven simplification. Investors should identify DeFi protocols securing these large-scale distribution deals and those building in tokenized RWAs and prediction markets.
  3. The "So What?": Coinbase's aggressive expansion into traditional assets, combined with Base App's creator-first, self-custodial "everything app" vision, signals a significant push for mainstream adoption. The next 6-12 months will see a race to onboard millions of new users and creators, fundamentally reshaping how we interact with finance and digital ownership.
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December 17, 2025

Hash Rate - Ep 151 - Bittensor EXPLOIT Summit March 30-31 SF

Hash Rate Podcast

Crypto
Key Takeaways:
  1. **Narrative Shift:** BitTensor is actively moving beyond its crypto-native roots to position itself as a serious, efficient platform for mainstream AI development.
  2. **Builder Opportunity:** For AI engineers, BitTensor offers a unique model to access distributed compute and talent, potentially reducing development costs and accelerating innovation.
  3. **Long-Term Play:** Exploit, scheduled for 2026, signals a long-term strategic vision for BitTensor's growth and mainstream adoption, requiring sustained community and developer engagement.
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December 17, 2025

Hash Rate - Ep 150 - Babelbit Subnet 59

Hash Rate Podcast

Crypto
Key Takeaways:
  1. AI Development Shift: BitTensor is redefining how complex AI is built, offering a decentralized, capital-efficient, and talent-rich alternative to traditional corporate and VC models.
  2. Investor Opportunity: This creates a new asset class for investors seeking early-stage AI exposure with token liquidity, but demands a high tolerance for volatility and a deep understanding of technical roadmaps.
  3. Builder's Playbook: For AI builders, BitTensor offers a platform to focus on core technology, leverage specialized models, and build interoperable services, accelerating innovation without the typical startup overhead.
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December 17, 2025

S3 Ep3_V1

The People's AI

Crypto
Key Takeaways:
  1. **Evolving Human-AI Interaction:** Our relationship with AI, especially digital personas, will evolve rapidly. Society will develop "genre literacy" to understand and integrate these new forms of connection.
  2. **Builder/Investor Note:** Prioritize user agency in design. Implement "sunsets" for grief bots and avoid intrusive notifications. Invest in decentralized data solutions that empower individual control over digital legacy.
  3. **The "So What?":** Grief tech forces a philosophical reckoning. As digital personas become more sophisticated, the very definition of "death" and "being alive" will blur, creating unprecedented social, legal, and economic implications.
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