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AI Podcasts

February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The US healthcare system is shifting from a reactive, acute care model to a proactive, preventative one.
  2. Build infrastructure that financially incentivizes preventative lifestyle interventions.
  3. The next decade will see hundreds of billions of dollars redirected towards lifestyle interventions.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. AI-driven hyperdeflation will fundamentally alter economic structures, leading to a post-scarcity future where the primary challenge shifts from production to distribution and the integration of human and machine economies.
  2. Invest in infrastructure that bridges human and AI economies, or prepare for a future where AI agents become a significant, crypto-native economic force.
  3. The next 6-12 months will see continued acceleration of AI capabilities, pushing us closer to a future where traditional labor and intelligence are nearly free. Understanding this change is crucial for navigating the emerging economic landscape and identifying new value creation opportunities.
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February 5, 2026

Goodfire AI’s Bet: Interpretability as the Next Frontier of Model Design — Myra Deng & Mark Bissell

Latent Space

AI
Key Takeaways:
  1. The era of opaque, black-box AI is ending; the future demands intentionally designed models with human understanding and control. This shift is driven by reliability in high-stakes applications and extracting novel insights.
  2. Investigate interpretability tools (like Goodfire's platform) to gain granular control over model behavior, moving beyond basic fine-tuning for critical applications.
  3. Interpretability is not a niche; it's the missing piece for scaling AI safely into mission-critical domains. Mastering model understanding and intentional design will yield unprecedented capabilities and competitive advantage.
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February 4, 2026

Ep#61: 1x World Model

RoboPapers

AI
Key Takeaways:
  1. Robotics is moving from bespoke, data-hungry behavior cloning to generalized, human-informed learning via world models. This shift, mirroring the success of LLMs, means robots can use the vast, unstructured data of human experience to acquire new skills.
  2. Invest in platforms and data pipelines that facilitate multi-modal, multi-stage training for humanoid robots. Prioritize systems that can generate synthetic data and use world models for high-throughput, targeted policy evaluation.
  3. World models are the engine for scalable robot intelligence. They promise a future where robots learn faster, generalize wider, and self-improve through iterative simulation, making widespread humanoid deployment a near-term reality.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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Crypto Podcasts

December 11, 2025

The Airdrop Mistake Luca Netz Won’t Repeat

The DCo Podcast

Crypto
Key Takeaways:
  1. Prioritize Early Alignment: To benefit from Abstract's ecosystem rewards, demonstrate commitment now, not right before a potential airdrop.
  2. Community Over Opportunism: Future rewards will favor genuine holders and active community members over short-term profit seekers.
  3. No Second Chances: Don't expect warnings or sympathy if you try to "grift" the system; Netz is committed to protecting loyal users.
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December 11, 2025

The Return of Corporate Blockchains | Roundup

Bell Curve

Crypto
Key Takeaways:
  1. Enterprise blockchains are making a comeback by embracing crypto, not avoiding it, marking a significant shift from the failed attempts of 2018.
  2. The success of corporate chains hinges on strategic focus, prioritizing ecosystems and BD, over trying to dominate the entire value chain, as too much control can stifle innovation.
  3. Public, permissionless blockchains must remain relevant by continually finding product-market fit in emerging segments to maintain their monetary premium amid increasing competition from verticalized corporate chains.
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December 10, 2025

Ethereum's New Era of Internet Capital Formation! The Return of the ICO

Bankless

Crypto
Key Takeaways:
  1. **ICOs are evolving:** The return of ICOs marks a shift from hype-driven raises to more sustainable models focused on established projects and fair price discovery.
  2. **Ethereum is primed for capital formation:** With its stablecoin liquidity, auction mechanisms, and tokenization narrative, Ethereum is positioned to become a central hub for internet capital markets.
  3. **Regulatory clarity is crucial:** The industry must continue to pursue regulatory clarity to foster innovation and attract institutional investment in tokenized assets.
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December 9, 2025

How MetaDAO Became Solana's Breakout Token Launchpad | Kollan House

Lightspeed

Crypto
Key Takeaways:
  1. Embrace Futarchy: Explore and implement market-driven governance mechanisms to enhance decision-making in decentralized organizations, reducing reliance on traditional, potentially biased, governance models.
  2. Prioritize Investor Protection: Adopt capital formation models, such as MetaDAO's, that offer robust investor protections through market-based checks and balances, mitigating risks associated with centralized control and poorly informed token allocation.
  3. Prepare for Crypto-Native Solutions: Build cryptonative primitives that can compete with traditional financial systems. This can prevent tradFi from dominating the blockchain space.
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December 8, 2025

Institutional Flows Will Overpower the 4-Year Cycle

Empire

Crypto
Key Takeaways:
  1. The traditional four-year crypto cycle is dead; institutional adoption and regulatory tailwinds will drive the next phase.
  2. Focus on easy-to-understand narratives; financial advisors allocate minimal time to crypto, so simple concepts are crucial.
  3. The increasing convergence of equity and tokens will lead to a new era of ICOs, revolutionizing fundraising and investment.
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December 8, 2025

Inside Gary Gensler’s SEC: A Conversation with Former Crypto Policy Advisor

Bankless

Crypto
Key Takeaways:
  1. **Regulation is inevitable:** Crypto's foray into traditional financial activities necessitates regulatory oversight to protect investors and maintain market integrity.
  2. **Compliance is key:** Crypto firms seeking legitimacy and long-term sustainability must prioritize regulatory compliance and address inherent conflicts of interest.
  3. **Philosophical divide persists:** Fundamental disagreements regarding decentralization, code as speech, and the role of intermediaries continue to fuel tensions between the SEC and the crypto industry.
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