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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

December 24, 2025

Why It Matters That Crypto Is Not Purely for Degens Anymore: DEX in the City

Unchained

Crypto
Key Takeaways:
  1. The Macro Shift: Crypto is adapting to the real world rather than forcing the world to adapt to it.
  2. The Tactical Edge: Build for institutional compatibility by integrating modular compliance tools before they become mandatory.
  3. The Bottom Line: The death of "crypto" as a niche category is the birth of crypto as a global standard.
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December 23, 2025

Is Now a Good Time to Buy BTC? Or Should You Wait for THIS Setup? - Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. The Macro Shift: Deregulation is the new meta-theme. As the "Empire Strikes Back," traditional giants like Visa and Stripe will integrate crypto rails and turn the tech into invisible "TCP/IP" for finance.
  2. The Tactical Edge: Monitor M&A activity during holiday periods. Look for "quality supply" consolidation where winners absorb the IP of failing projects.
  3. The Bottom Line: 2026 is the target for a high-quality rally. The current shakeout is a feature designed to filter out the "nonsense supply" before the $40 trillion RIA channel arrives.
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December 24, 2025

How Crypto Users Get Rekt and How You Can Stay Safe

Unchained

Crypto
Key Takeaways:
  1. The Human Layer Exploit. As code becomes more robust, the attack surface moves to the people managing it. Security is now an HR and psychology problem as much as a technical one.
  2. Deploy YubiKeys. Replace SMS and app-based 2FA with hardware keys to stop phishing. If a site cannot talk to your physical key, the attacker cannot steal your session.
  3. Security is a process of adding layers, not a one-time audit. If you do not have a "blast radius" strategy to isolate your funds, you are one bad click away from a total loss.
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December 24, 2025

Regulation Shifts as Security Becomes the Real Risk

Unchained

Crypto
Key Takeaways:
  1. The Macro Evolution: The Institutional Osmosis. Crypto is no longer a parallel universe but a high-speed rail for traditional assets.
  2. The Tactical Edge: Audit Your Humans. Implement "Camera-On" policies and cross-verify identities via physical meetups to neutralize remote infiltration.
  3. The Bottom Line: Survival in the next 12 months depends on moving from "Degen" security to "Enterprise" resilience as the lines between Coinbase and BlackRock vanish.
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December 23, 2025

The End of Forever Games Is Closer Than You Think

The DCo Podcast

Crypto
Key Takeaways:
  1. The Macro Shift: Content Abundance vs. Attention Scarcity. As AI makes the "what" of gaming cheap, the "where" (distribution) and "who" (high-LTV users) become the only defensible assets.
  2. The Tactical Edge: Skin the Game. Use AI to rapidly iterate on visual assets for existing mechanics to capture trending subcultures within crypto communities.
  3. The Bottom Line: The future of gaming isn't about building a 10-year world; it's about building high-fidelity, ephemeral experiences that drive value to on-chain ecosystems.
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December 23, 2025

Ben Cowen on Where Crypto is Going in 2026

Bankless

Crypto
Key Takeaways:
  1. The Macro Shift: Macro gravity is currently winning as high interest rates suppress risk-on assets while AI captures the remaining speculative energy.
  2. The Tactical Edge: Accumulate Ethereum only when it enters the regression band and Bitcoin when it touches the 200-week moving average.
  3. The Bottom Line: The next major opportunity likely arrives in the summer of 2026 when monetary policy finally turns accommodative and the labor market stabilizes.
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