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AI Podcasts

May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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May 25, 2025

How Endless Debt Became America's Culture

Forward Guidance

AI
Key Takeaways:
  1. **Debt is Destiny:** America's fiscal irresponsibility and cultural embrace of debt ensure ongoing money printing and inflation, making currency debasement a near certainty.
  2. **The One True Trade:** Forget complex analytics; the primary goal is preserving purchasing power. This means owning store-of-value assets like Bitcoin and gold, which are positioned to thrive.
  3. **AI Accelerates the Crisis:** Artificial intelligence will not only disrupt labor markets but also intensify the debt crisis by devaluing traditional education and fueling calls for more government relief.
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May 24, 2025

SN85 :: VIDAIO :: Decentralized AI Video Upscaling & Compression ++ Roadmap & Enterprise Utility

Opentensor Foundation

AI
Key Takeaways:
  1. Decentralized AI is Production-Ready: VIDAIO demonstrates that complex AI tasks like video processing can be effectively decentralized and optimized through BitTensor's subnet model, with miners already outperforming base models.
  2. Perceptual Quality Wins: Focusing on human-perceived video quality, rather than just raw specs, is key for AI video tools, leading to more efficient and visually appealing results.
  3. Subnets Must Aim for Self-Sufficiency: The long-term viability of BitTensor subnets hinges on generating real-world revenue and solving actual customer problems, moving beyond reliance on token emissions.
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May 24, 2025

Sovereign AI: Why Nations Are Building Their Own Models

a16z

AI
Key Takeaways:
  1. National AI is Non-Negotiable: Countries are investing heavily in "AI factories" to control their digital destiny and cultural narratives.
  2. Models are Culture: AI outputs reflect embedded values, making local control over AI development and deployment a geopolitical imperative.
  3. Lead by Building Better: The US can maintain AI leadership by out-innovating competitors and enabling allies, pursuing "foundation model diplomacy" to ensure its technology underpins global progress.
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Crypto Podcasts

August 26, 2025

Why I Sold Some Crypto & Prediction Markets Alpha

Taiki Maeda

Crypto
Key Takeaways:
  1. Re-evaluate Risk/Reward. With majors like Ethereum potentially offering symmetrical 50% upside vs. 50% downside, the rationale for holding heavy, levered positions weakens. It's time to take some chips off the table.
  2. Explore Prediction Markets. This sector offers a fresh frontier for alpha. Get active on Polymarket, farm the Limitless airdrop on Base (min. $200 bet), and join Outcome’s risk-free testnet competition to get exposure.
  3. Build a Defensive Core. Adopt assets like JLP on Solana as a portfolio cornerstone. It provides market exposure while protecting capital through its diversified pool and fees generated from retail traders, outperforming most crypto assets in a downturn.
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August 26, 2025

Will Crypto Peak in 2025… or Run Into 2026? Onchain Data Signals

Bankless

Crypto
Key Takeaways:
  1. **This Time Might Be Different.** Macro indicators like loosening bank lending standards, mid-range equity valuations, and a dovish Fed signal the business cycle is earlier than many believe, favoring a cycle extension into 2026 over a 2025 peak.
  2. **On-Chain Metrics Show No Signs of a Top.** Key on-chain data is far from euphoric. The Bitcoin Fear & Greed index is neutral, and while long-term holders are selling, it’s being absorbed without triggering the "extreme greed" that defines market tops.
  3. **Build a Concentrated, High-Conviction Portfolio.** Don't "diworsify." Anchor 70%+ of your portfolio in core assets (BTC, ETH), benchmark all other bets against them, and use small "hot sauce" allocations (5-10%) for high-risk plays while always maintaining cash to buy the dips.
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August 25, 2025

Can Rate Cuts Save Crypto’s Bull Market?

1000x Podcast

Crypto
Key Takeaways:
  1. **Macro is your north star.** The crypto market's direction is dictated by Fed policy. Rate cuts are the narrative, and trillions are waiting on the sidelines to flood into risk assets.
  2. **Take profits aggressively.** We are in the "stupid" phase of the cycle. Systematically sell portions of your holdings at 20%, 50%, and 100% gains to de-risk before the music stops.
  3. **Scrutinize DAOs.** Many are exit liquidity schemes. Only consider those with strong guardrails, like mandatory fresh capital matching, that bring new money into the ecosystem.
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August 25, 2025

Commissioner Peirce On SEC’s Next Moves

Empire

Crypto
Key Takeaways:
  1. Frameworks, Not Fights: The SEC is shifting from broad prohibitions to creating specific, workable rules for token launches. The goal is to bring this crucial capital formation activity back to the U.S. under a clear and compliant regime.
  2. Decentralization Changes the Game: True decentralization isn't just a buzzword; it fundamentally challenges the existing regulatory model. For truly peer-to-peer protocols, the old playbook of licensing intermediaries may no longer apply.
  3. The Best Defense is Utility: The crypto industry's greatest protection against future regulatory hostility is to build things with real, lasting value. Use this period of clearer skies to create products and services that prove the technology's worth beyond speculation.
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August 24, 2025

Will LINK Flip XRP? with Zach Rynes

The Rollup

Crypto
Key Takeaways:
  1. Bet on the Ecosystem, Not the Silo: Chainlink’s value is tied to the growth of the entire blockchain space, making it a diversified bet on institutional adoption. XRP’s success is a narrow wager on its own ledger and asset gaining dominance.
  2. Follow the Proof, Not the Promises: Chainlink’s public partnerships with firms like Swift and JP Morgan provide concrete evidence of traction. This stands in sharp contrast to XRP's long-unfulfilled, NDA-shrouded narrative.
  3. Infrastructure is the Ultimate Power Play: By providing a comprehensive suite of essential services (data, cross-chain, compliance), Chainlink is building a defensible moat as the go-to infrastructure platform for Web3, with no direct all-in-one competitor in sight.
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August 23, 2025

Former Yahoo Music Executive on Crypto's Inevitable Centralization Points with Ian Rogers

The Rollup

Crypto
Key Takeaways:
  1. **Value is a Function of Time:** Bitcoin's greatest asset is its 15-year track record. Lasting value isn't about technology alone; it's about a powerful story that withstands the test of time, creating an insulated brand.
  2. **Self-Custody is the Premise:** The entire value proposition of crypto hinges on eliminating counterparty risk. Compromising on self-custody and security for the sake of convenience is a recurring mistake that "always blows up."
  3. **Adoption Will Be Abstracted:** The future of crypto for the masses is one where the complexity is hidden. Centralized user experiences will run on decentralized rails, delivering the benefits of crypto (lower fees, faster settlement) without the unforgiving user experience.
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