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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

February 16, 2026

Does Bitcoin Win or Lose In The Great AI-Tech Shakeout?

Unchained

Crypto
Key Takeaways:
  1. Bitcoin, once digital gold, is now frontier tech, vulnerable to broader tech sell-offs.
  2. Reallocate capital towards crypto assets benefiting from regulatory clarity and innovation: stablecoins, tokenized assets, privacy, prediction markets, perpetual futures.
  3. Bitcoin's short-term narrative is challenged, but its long-term tech thesis holds.
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February 17, 2026

Soft Jobs, AI CapEx Surge, and Institutions Move Onchain: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Real-time data platforms are supplanting traditional economic reporting, forcing investors to re-evaluate their information sources, while AI's capital expenditure is creating a bifurcation between infrastructure providers and speculative model companies.
  2. Prioritize investments in blockchain infrastructure and stablecoin-centric payment solutions that cater to the emerging agentic economy, and leverage real-time data for a competitive information advantage.
  3. The convergence of real-time data, AI agents, and blockchain rails will fundamentally alter market dynamics and value capture over the next 6-12 months, rewarding those who understand the shift from centralized, lagging systems to decentralized, optimized ones.
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February 17, 2026

Bitcoin Is Either Going To Zero Or A Million

1000x Podcast

Crypto
Key Takeaways:
  1. The Macro Shift: AI is fundamentally reshaping corporate IT spending, driving a strategic pivot from external SaaS subscriptions to internal development, which will consolidate profits within mega-cap tech and pressure traditional software vendors.
  2. The Tactical Edge: Identify and invest in vertically integrated tech giants that can leverage AI for internal cost savings and new product development, while selectively shorting asset-heavy, midstream, or non-essential SaaS providers during strength.
  3. The Bottom Line: The current market is a re-evaluation of fundamental value across tech and crypto. Focus on companies with strong internal demand for compute and real-world utility, and understand that crypto's speculative cycles, while volatile, are driven by a unique social dynamic that will persist.
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February 16, 2026

MegaETH in 2026 & Ethereum's L2 End Game | Brett DiNovi & Lei Yang

Empire

Crypto
Key Takeaways:
  1. High-performance L2s are carving out new market segments by prioritizing user experience and speed over strict L1 equivalence, challenging traditional value accrual models.
  2. Builders should target L2s offering ultra-low latency and predictable costs for consumer-facing DeFi and gaming, as these environments enable novel, sticky applications.
  3. The next wave of crypto adoption hinges on L2s that can deliver real-time, seamless experiences, shifting value capture from L1 monetary premium to execution premium and innovative tokenomics.
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February 16, 2026

Lyn Alden: How to Survive The Gradual Print Era — Fed Chair Warsh, Gold & Bitcoin

Bankless

Crypto
Key Takeaways:
  1. The global monetary order is transitioning from a unipolar, dollar-dominant system to a multipolar one, driven by sovereign debt and geopolitical competition. This change elevates neutral reserve assets and challenges traditional financial institutions.
  2. Diversify your portfolio across high-quality equities (with an international and value tilt), hard assets (gold, silver, platinum, Bitcoin), and real-world assets like energy infrastructure. Maintain 5-10% cash for opportunities.
  3. The "gradual print" and ongoing monetary reordering mean sustained debasement of fiat currencies. Positioning in hard assets and resilient, undervalued real-world businesses is crucial for preserving and growing wealth over the next 6-12 months.
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February 16, 2026

As the AI Trade Cools Off, Are Bitcoin Miners Still a Buy?

Unchained

Crypto
Key Takeaways:
  1. The relentless demand for AI compute is transforming Bitcoin miners from speculative, commodity-dependent entities into stable, infrastructure-as-a-service providers. This pivot leverages their core asset—cheap power—to capture predictable, high-margin revenue streams.
  2. Evaluate Bitcoin mining stocks based on their AI contract pipeline, execution capabilities, and access to consistent power, rather than solely on Bitcoin price correlation. Prioritize those with colocation leases to minimize GPU capex risk.
  3. The strategic shift to AI offers a compelling de-risking narrative for Bitcoin miners, potentially leading to higher valuations and more stable cash flows. However, investors must monitor execution risks and political headwinds around power access over the next 6-12 months.
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