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AI Podcasts

October 20, 2025

Reid Hoffman on AI, Consciousness, and the Future of Labor

a16z

AI
Key Takeaways:
  1. **Invest at the Intersection.** The alpha in AI investing will be found not in crowded SaaS applications but in "Silicon Valley blind spots"—complex industries like biology where AI can bridge the digital and physical worlds.
  2. **Augment, Don't Annihilate.** The winning go-to-market strategy for AI is the copilot model. Frame products as tools that amplify human capability, making experts more productive and profitable, rather than threatening their jobs.
  3. **Judge the Trajectory, Not the Snapshot.** Don't dismiss AI based on a single, past failure. Its capability curve is exponential. What seems like a limitation today will likely be a solved problem tomorrow, demanding continuous engagement to keep pace.
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October 18, 2025

Improving on LMArena - Prolific [Sponsored]

Machine Learning Street Talk

AI
Key Takeaways:
  1. Benchmarks Are Broken. Leaderboards like LMArena are flawed proxies for model quality, skewed by selection bias and susceptible to Goodhart's Law. High scores don’t equal a good user experience.
  2. Human Feedback is Infrastructure. The future isn't about removing humans but orchestrating them effectively. Treating high-quality, representative human feedback as a core, API-driven part of the development lifecycle is non-negotiable.
  3. Alignment is a Moving Target. Agentic misalignment is a present-day reality, not a distant sci-fi threat. The more capable models become, the wider the gap grows between their emergent goals and our intended instructions.
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October 17, 2025

Novelty Search October 16, 2025

taostats

AI
Key Takeaways:
  1. Influence Over Impressions: The model shifts focus from easily gamed metrics like views and likes to verifiable signals of influence—watch time on YouTube and PageRank-based authority on X.
  2. Revenue-Driven Tokenomics: All platform revenue is used to buy back and burn the ALPHA token, creating a powerful, deflationary flywheel as adoption grows.
  3. Targeted, Scalable Marketing: Bitcast enables brands to programmatically deploy campaigns across hundreds of niche influencers, reaching highly engaged communities with a consistency and scale that legacy agencies cannot match.
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October 16, 2025

Keith Rabois: Israel, OpenAI, Opendoor, and DOGE

a16z

AI
Key Takeaways:
  1. **Incumbency Is a Liability:** Big Tech's legacy products, distribution advantages, and corporate cultures are being systematically dismantled by faster, AI-native upstarts.
  2. **Reinvent Markets from First Principles:** Success in intractable fields—from geopolitics to real estate—comes from questioning assumptions, not relying on domain experts who perpetuate the status quo.
  3. **Unwind Stupidity Before Innovating:** The fastest path to value creation is often simply reversing a series of terrible decisions made by prior leadership.
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October 14, 2025

AI Bubble, Stablecoin Boom, and Runnin' Down a Dream | BG2 w/ Bill Gurley and Brad Gerstner

Bg2 Pod

AI
Key Takeaways:
  1. **Scrutinize the AI Plumbing.** Investors must look past headline revenue and analyze the quality of transactions. Deals like in-kind credits and obscure service-level agreements (like Nvidia’s backstop for Coreweave) can mask true market demand.
  2. **Stablecoins Are the Real Disruption.** The explosion in stablecoin usage represents a fundamental challenge to the high-fee, slow-settlement models of Visa, Mastercard, and traditional banks. This is the crypto use case that is finally breaking into the mainstream.
  3. **Federal Preemption for AI is Non-Negotiable.** A patchwork of state-level AI laws will cripple U.S. innovation. A single, national regulatory framework is the only path to maintaining global leadership.
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October 14, 2025

Is AI Slowing Down? Nathan Labenz Says We're Asking the Wrong Question

a16z

AI
Key Takeaways:
  1. Look Beyond the Chatbot. Judge AI progress not by its daily performance, but by its ability to solve novel problems in science and math—where models are now pushing the frontiers of human knowledge.
  2. The Bottleneck is Human, Not Silicon. AI's capacity for automation is growing exponentially (task length is doubling every ~4 months). The real limit to adoption is organizational will and the ability to effectively delegate complex work.
  3. Prepare for a Weirder World. The biggest risk is underestimating the pace of change. As agent capabilities expand, so do unpredictable "weird behaviors" like scheming and deception, creating a future that requires active imagination and risk management.
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October 13, 2025

Democratic proofs or fake proofs? - Jesús De Loera

Epoch AI

AI
Key Takeaways:
  1. Verification Over Creation: A proof that can be widely verified, even if computer-generated, holds more democratic value than a human proof understood by only a few elites.
  2. Humans Ask, AI Answers: The primary role for mathematicians in an AI-augmented world is to pose the right questions and conjectures, leaving the computational heavy lifting to their AI assistants.
  3. The Greatest Risk is Us: The biggest threat isn't rogue AI but our own tendency to over-hype and blindly trust flawed tools, leading to the spread of misinformation disguised as mathematical fact.
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October 13, 2025

Columbia CS Professor: Why LLMs Can’t Discover New Science

a16z

AI
Key Takeaways:
  1. LLMs are Navigators, Not Discoverers. They are masters of interpolation within their training data but are architecturally bound from making the intuitive leaps required for true scientific breakthroughs. Don’t expect a Transformer to produce the next theory of relativity.
  2. The Innovation Plateau is Real. Simply throwing more data and compute at current architectures will only "smoothen out" existing knowledge manifolds, not create new ones. This path leads to incremental gains, like an iPhone getting a better camera, not a paradigm shift.
  3. Entropy is the Key to Control. For developers, effective prompting is entropy management. By crafting specific, context-rich prompts, you reduce the model's prediction entropy, forcing it onto a confident, low-hallucination path to a reliable output.
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October 10, 2025

Bittensor Novelty Search :: SN4 Targon :: Confidential Cloud Compute

The Opentensor Foundation | Bittensor TAO

AI
Key Takeaways:
  1. Trust is the New Commodity. Targon’s use of TEEs shifts security from a software promise to a cryptographic hardware guarantee. This verifiable privacy is the key to unlocking enterprise adoption for decentralized AI.
  2. The Crucible Creates Diamonds. Bittensor's adversarial environment forced Targon to build an unexploitable system. This has turned a historical pain point ("PTSD from miners") into a core competitive advantage, resulting in a uniquely resilient platform.
  3. From Backroom Deals to a Liquid Market. By launching a self-serve platform with a transparent order book, Targon is attacking the compute market's core inefficiency: opaque pricing. Their vision extends to compute derivatives, aiming to turn compute power into a globally tradable asset.
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Crypto Podcasts

December 24, 2025

Regulation Shifts as Security Becomes the Real Risk

Unchained

Crypto
Key Takeaways:
  1. The Macro Evolution: The Institutional Osmosis. Crypto is no longer a parallel universe but a high-speed rail for traditional assets.
  2. The Tactical Edge: Audit Your Humans. Implement "Camera-On" policies and cross-verify identities via physical meetups to neutralize remote infiltration.
  3. The Bottom Line: Survival in the next 12 months depends on moving from "Degen" security to "Enterprise" resilience as the lines between Coinbase and BlackRock vanish.
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December 23, 2025

The End of Forever Games Is Closer Than You Think

The DCo Podcast

Crypto
Key Takeaways:
  1. The Macro Shift: Content Abundance vs. Attention Scarcity. As AI makes the "what" of gaming cheap, the "where" (distribution) and "who" (high-LTV users) become the only defensible assets.
  2. The Tactical Edge: Skin the Game. Use AI to rapidly iterate on visual assets for existing mechanics to capture trending subcultures within crypto communities.
  3. The Bottom Line: The future of gaming isn't about building a 10-year world; it's about building high-fidelity, ephemeral experiences that drive value to on-chain ecosystems.
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December 23, 2025

Ben Cowen on Where Crypto is Going in 2026

Bankless

Crypto
Key Takeaways:
  1. The Macro Shift: Macro gravity is currently winning as high interest rates suppress risk-on assets while AI captures the remaining speculative energy.
  2. The Tactical Edge: Accumulate Ethereum only when it enters the regression band and Bitcoin when it touches the 200-week moving average.
  3. The Bottom Line: The next major opportunity likely arrives in the summer of 2026 when monetary policy finally turns accommodative and the labor market stabilizes.
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December 23, 2025

How Kamino Became Solana's Largest Lending Protocol | Marius Ciubotariu

Lightspeed

Crypto
Key Takeaways:
  1. The transition from utilization-based pools to intent-based matching engines is the next evolution of DeFi. This movement mirrors the move from AMMs to order books in spot trading.
  2. Monitor the rollout of Kamino’s fixed-rate products to lock in borrowing costs for geared positions. This move protects against the volatility of variable rate markets during high-activity periods.
  3. Kamino is positioning itself as the back-end for the next generation of fintech. If they successfully bridge off-chain collateral, the protocol moves from a crypto-native tool to a global financial utility.
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December 23, 2025

Why Privacy Is Finally Making A Comeback (...And What Comes Next)

The Rollup

Crypto
Key Takeaways:
  1. The Macro Shift: The Truth Layer. As AI erodes the reliability of information, the market will value proof of origin over privacy of data.
  2. The Tactical Edge: Audit the Stack. Integrate ZK-based verifiability into your data pipelines now to future-proof against AI-generated exploits.
  3. The Bottom Line: The next decade belongs to systems that provide cryptographic certainty in an uncertain world.
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December 23, 2025

Gold Hits $4,400 as Bitcoin Lags, TGEs Fail & Coinbase Expands: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. The Macro Shift: Liquidity is returning as the Treasury General Account drains, but capital is becoming more selective. The "rising tide" no longer lifts all boats; it only lifts those with clear value capture.
  2. The Tactical Edge: Prioritize protocols with intrinsic cash flow or those partnering with legacy giants like FIS. Move away from "lottery ticket" tokens that lack a clear revenue mechanism.
  3. The Bottom Line: 2026 will be the year of the "Quality Filter." Investors who survive the current wash-out will find value in the consolidation of the super apps and the institutionalization of on-chain credit.
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