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AI Podcasts

May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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May 25, 2025

How Endless Debt Became America's Culture

Forward Guidance

AI
Key Takeaways:
  1. **Debt is Destiny:** America's fiscal irresponsibility and cultural embrace of debt ensure ongoing money printing and inflation, making currency debasement a near certainty.
  2. **The One True Trade:** Forget complex analytics; the primary goal is preserving purchasing power. This means owning store-of-value assets like Bitcoin and gold, which are positioned to thrive.
  3. **AI Accelerates the Crisis:** Artificial intelligence will not only disrupt labor markets but also intensify the debt crisis by devaluing traditional education and fueling calls for more government relief.
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May 24, 2025

SN85 :: VIDAIO :: Decentralized AI Video Upscaling & Compression ++ Roadmap & Enterprise Utility

Opentensor Foundation

AI
Key Takeaways:
  1. Decentralized AI is Production-Ready: VIDAIO demonstrates that complex AI tasks like video processing can be effectively decentralized and optimized through BitTensor's subnet model, with miners already outperforming base models.
  2. Perceptual Quality Wins: Focusing on human-perceived video quality, rather than just raw specs, is key for AI video tools, leading to more efficient and visually appealing results.
  3. Subnets Must Aim for Self-Sufficiency: The long-term viability of BitTensor subnets hinges on generating real-world revenue and solving actual customer problems, moving beyond reliance on token emissions.
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May 24, 2025

Sovereign AI: Why Nations Are Building Their Own Models

a16z

AI
Key Takeaways:
  1. National AI is Non-Negotiable: Countries are investing heavily in "AI factories" to control their digital destiny and cultural narratives.
  2. Models are Culture: AI outputs reflect embedded values, making local control over AI development and deployment a geopolitical imperative.
  3. Lead by Building Better: The US can maintain AI leadership by out-innovating competitors and enabling allies, pursuing "foundation model diplomacy" to ensure its technology underpins global progress.
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Crypto Podcasts

October 14, 2025

LIVE from Digital Asset Summit

Forward Guidance

Crypto
Key Takeaways:
  1. The Crash Was Technical, Not Existential: This wasn't another Luna. It was a liquidity-driven cascade originating from centralized exchanges that wiped out leveraged retail, while DeFi infrastructure proved its mettle. The fundamental bull case remains intact.
  2. Bitcoin is a Different Animal: The stark performance divergence between a resilient Bitcoin and collapsing altcoins is the clearest signal yet that BTC now plays in a different, institutionalized league. The speculative fervor in "useless alts" is dead for the foreseeable future.
  3. Institutions Are Buying the Debasement Story, Not the Dip: Professional investors, insulated by ETFs, completely missed the weekend's volatility. Their focus is unchanged: allocating more capital (now 3-5%) to the "purification trade" as a hedge against unstoppable fiat debasement.
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October 11, 2025

ETH Supply Shock Could Ignite Explosive Rally

Forward Guidance

Crypto
Key Takeaways:
  1. Supply Shock Imminent: Corporate ETH accumulation is happening faster and with greater relative market impact than Bitcoin's history, creating a coiled spring for price.
  2. The Stage is Set: Profit-taking from old holders is complete, hype has died down, and leverage has been wiped out. The path of least resistance for ETH is now up.
  3. Follow the Smart Money: ETH is not just a crypto play; it's a macro-correlated, high-beta bet endorsed by some of the world's sharpest investors.
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October 10, 2025

CRYPTO MARKET CRASH EMERGENCY LIVESTREAM

Taiki Maeda

Crypto
Key Takeaways:
  1. Survive First, Profit Later. The market always presents new opportunities, but only for those who preserve capital. Avoid leverage and hold significant stablecoin allocations to capitalize on moments of extreme fear, not become a victim of them.
  2. Find Your Asymmetric Edge: Farm, Don't Buy. Retail investors cannot out-trade funds with insider information. The real edge is in airdrop farming—getting into promising protocols early and selling the token to the masses who buy on inflated centralized exchange listings.
  3. The Altcoin Reckoning is Here. The belief that a rising Bitcoin lifts all boats is a dangerous assumption. Most alts are overvalued and lack a fundamental thesis beyond momentum. Prepare for a future where Bitcoin grinds higher while most of the altcoin market bleeds out.
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October 10, 2025

Polymarket's $2B Deal with ICE Changes Everything | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. Founder Vision Outweighs Everything. Polymarket’s story proves that a founder with an unwavering, maniacal vision can overcome technical hurdles, regulatory threats, and brutal bear markets. Shane won by being an unstoppable evangelist.
  2. Abstraction Is the Key to Mass Adoption. The best crypto apps don't feel like crypto apps. Polymarket’s success comes from hiding the blockchain complexity, a lesson for every builder aiming for mainstream relevance.
  3. Bet on Second-Order Effects. The surge in BNB isn't about BSC's tech; it's a proxy bet on CZ's return. Smart investors look past the immediate narrative to trade the powerful undercurrents shaping the market.
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October 10, 2025

Novelty Search october 9, 2025

taostats

Crypto
Key Takeaways:
  1. Security Through Adversity: Targon’s "PTSD" from battling malicious miners forced them to build a cryptographically secure compute layer using TEEs, making their platform more resilient than siloed, trusted alternatives.
  2. DeFi Meets DePIN: They are building a transparent financial market for compute, complete with order books and derivatives. The goal isn’t just to rent GPUs; it’s to create the pricing infrastructure for the entire compute economy.
  3. The Foundational Layer: Targon is providing a verifiable, secure, and cost-effective compute service that other BitTensor subnets can build upon, potentially supercharging the entire network’s growth and competitive advantage.
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October 10, 2025

Why This Early Solana Investor Is Still All In | Viktor Fischer

Lightspeed

Crypto
Key Takeaways:
  1. **The L1 War Is Won.** Don't bet on new L1s. The network effects, developer mindshare, and ecosystem infrastructure of chains like Solana and Base have created an insurmountable moat.
  2. **DATs Are the Trojan Horse for TradFi.** Digital Asset Treasury companies are the key to unlocking Wall Street capital. Expect Solana DATs to drive a massive TVL re-rating in 2026 as their superior yield generation becomes undeniable.
  3. **SOL to $2,000 Is the Base Case.** This price target isn't based on meme-fueled hype, but on a model where Solana captures just 10% of the projected multi-trillion-dollar tokenized asset market by 2030.
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