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AI Podcasts

May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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May 25, 2025

How Endless Debt Became America's Culture

Forward Guidance

AI
Key Takeaways:
  1. **Debt is Destiny:** America's fiscal irresponsibility and cultural embrace of debt ensure ongoing money printing and inflation, making currency debasement a near certainty.
  2. **The One True Trade:** Forget complex analytics; the primary goal is preserving purchasing power. This means owning store-of-value assets like Bitcoin and gold, which are positioned to thrive.
  3. **AI Accelerates the Crisis:** Artificial intelligence will not only disrupt labor markets but also intensify the debt crisis by devaluing traditional education and fueling calls for more government relief.
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Crypto Podcasts

October 17, 2025

Is the Crypto Bull Market Over? Gold All-Time Highs, Crypto Whipsaws: Are We Topping or Resetting?

Bankless

Crypto
Key Takeaways:
  1. Leverage is the market's double-edged sword. The $19B flash crash was a cascade failure driven by leverage, not fundamentals. It exposed the fragility of perpetual exchanges and the critical risk of Auto-Deleveraging (ADL) even for sophisticated traders.
  2. Wall Street is tokenizing everything. Larry Fink and BlackRock are building the operating system to move trillions in traditional assets on-chain. This isn't a speculative bet; it's a core strategy to capture a massive, untapped global market.
  3. Infrastructure is maturing, but risks are shifting. While core DeFi protocols proved bulletproof under stress, centralized exchanges and their oracle dependencies remain a systemic weak point, as shown by Binance's API failures and the resulting market chaos.
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October 17, 2025

Crypto Has Topped.

Taiki Maeda

Crypto
Key Takeaways:
  1. Altcoins Are Cooked. A decimated retail buyer base combined with relentless selling pressure from insider token unlocks creates a structurally bearish environment for the entire altcoin complex.
  2. Farm, Don't Buy. Stop being exit liquidity. The winning strategy is to farm airdrops to acquire tokens for free and become the one who sells at launch.
  3. Capital Preservation is King. The "one more 2x" mentality is a trap. Protect your gains by holding significant stablecoin reserves and acting quickly to de-risk. Take care of the downside, and the upside will take care of itself.
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October 17, 2025

Global Liquidity Cycle & the Worldwide Rush Into Hard Assets | Weekly Roundup

Forward Guidance

Crypto
Key Takeaways:
  1. Hard Assets Are The Only Exit. Governments must monetize their staggering debt, making monetary inflation hedges like gold and crypto essential. Gold’s recent surge is the canary in the coal mine, signaling a major catch-up move for Bitcoin is imminent.
  2. Forget the Trade War; Watch the Capital War. The real global conflict is financial. The US is building its future on digital dollars (stablecoins), while China is anchoring its system to gold. This divergence will define capital flows for the next decade.
  3. The Bitcoin 4-Year Cycle Is Dead. Treat Bitcoin as a global macro asset driven by liquidity and its relationship with gold. Its recent price consolidation is a sign of distribution from old hands to new institutional players, setting the stage for its next major move.
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October 15, 2025

Kyle Samani Thinks Solana Will Overtake Bitcoin and ETH

The DCo Podcast

Crypto
Key Takeaways:
  1. Utility Trumps Scarcity: The most valuable crypto asset will be the one powering the most economic activity, not simply the one with the most predictable supply.
  2. Solana’s Technical Roadmap is Key: A future state with multiple concurrent block producers will give Solana a decisive advantage in censorship resistance and performance over its rivals.
  3. Bet on SOL to Flip BTC: Samani’s core investment thesis is that as Solana’s real-world adoption becomes undeniable over the next decade, SOL is positioned to become the world’s number one crypto asset.
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October 15, 2025

Crypto's Biggest Liquidation, DAT Strategies, & The Purification Trade | Jeff Park

Forward Guidance

Crypto
Key Takeaways:
  1. Consolidation is Coming: The recent retail wipeout will likely funnel capital into higher-quality assets, with Bitcoin positioned to front-run altcoins in a reversal of typical bull market cycles.
  2. Reframe Debasement as Purification: The simultaneous rise of gold and Bitcoin isn't just a hedge; it's a fundamental repricing of value and a cleansing of a broken financial system, driven by geopolitical strategy.
  3. DATs are Not ETFs: Digital Asset Treasuries offer an active approach to crypto exposure, with smaller players uniquely positioned to capture on-chain alpha that is impossible for mega-holders to access.
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October 13, 2025

The Most Important Video I’ll Make This Year

Taiki Maeda

Crypto
Key Takeaways:
  1. **The Game Has Changed.** Stop trying to win by spot-buying overvalued altcoins in a market dominated by insiders. The real, sustainable edge is found on-chain through airdrop farming, which allows you to acquire tokens at a low cost basis and sell them to market hype.
  2. **Become an All-Weather Farmer.** Structure your portfolio defensively. A 50%+ stablecoin allocation is not being sidelined; it's a dry powder reserve that allows you to farm, hedge, and survive while others get wiped out. Your upside comes from farming, not from being 100% long.
  3. **Airdrops Are Your Asymmetric Bet.** Treat airdrop points as a call option on the entire crypto market. This allows you to stay risk-off with a large stablecoin position while retaining explosive upside potential if the market runs, creating a win-win scenario.
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