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AI Podcasts

August 23, 2025

Ben Horowitz on How a16z Was Built

a16z

AI
Key Takeaways:
  1. Build a Product, Not Just a Portfolio. The dominant VC firms of the future will offer concrete services to founders, not just capital. Reputation and unwavering founder support are the ultimate competitive advantages.
  2. Size Funds to the Market Opportunity. The software market is exponentially larger than it was two decades ago. Sticking to legacy fund sizes means missing out on a dramatically expanded opportunity set.
  3. Fight for American Innovation. The biggest existential threat to technology isn't market cycles but a hostile regulatory environment. VCs must actively engage in policy to prevent the US from forfeiting leadership in foundational technologies like AI and crypto.
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August 22, 2025

ONESHOTTED

Trillion Agents

AI
Key Takeaways:
  1. Execution is a Commodity; Ideation is the Moat. The value is rapidly shifting from those who can execute a plan to those who can generate the novel plan in the first place.
  2. Your Org Chart is Now a Repo. Forward-thinking teams are treating their entire operational knowledge base as a single, AI-readable context, turning their company's history and philosophy into a prompt.
  3. Beware the Conflict Resolution Engine. A centralized AI risks becoming an echo chamber that smooths over disagreements. Actively engineer processes (like human-led PR reviews) to preserve essential conflict and challenge groupthink.
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August 22, 2025

The State of AI: Growth, Fragmentation, and the Next Wave

a16z

AI
Key Takeaways:
  1. Zero-Sum is a Losing Bet. The market isn't a monolith. Value is fragmenting across specialized applications in code, image, and vertical workflows. The "winner-take-all" thesis is dead.
  2. Moats are Made, Not Inherent. AI’s magic solves the "bootstrap problem" of user acquisition, but long-term defensibility requires building traditional software moats like brand, workflow integration, and network effects.
  3. Be on the Field, but Pick Your Spot. This is not a market to sit out, but indiscriminate investing is a death sentence. Back exceptional, proven teams, understand that conflicts can lock you out of the best deals, and never confuse market heat with genuine momentum.
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August 21, 2025

Can AI Fix Housing and Healthcare Affordability?

a16z

AI
Key Takeaways:
  1. AI is the deflationary force for stagnant sectors. While software ate the world, it skipped housing and healthcare. AI is finally tackling the operational drag that has caused costs to balloon for decades.
  2. To solve the housing crisis, make it profitable. The path to more housing supply runs through better returns. By making property operations radically more efficient, AI attracts the capital required to build.
  3. The future of work is human + AI. Automation won't eliminate jobs; it will transform them. As AI handles the administrative grind, human roles will shift to higher-value work like community engagement and complex problem-solving.
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August 19, 2025

Hash Rate - Ep 129 - Macrocosmos IOTA (sn9) and DataUniverse (sn13)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. DTO Means Business: Dynamic TAO has forced a Darwinian shift. Subnets must now achieve product-market fit and generate real revenue to survive, transforming from research projects into self-sustaining businesses.
  2. IOTA’s Grand Ambition: IOTA (SN9) isn't just another model trainer; its architecture aims to train trillion-parameter models on decentralized, consumer-grade hardware, directly challenging the dominance of centralized AI labs.
  3. Time to Garden: The protocol's long-term health hinges on active governance. A strong sentiment is emerging to prune low-effort or malicious subnets to focus emissions on projects capable of creating real, lasting value.
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August 19, 2025

Hash Rate - Ep 128 - Ridges ($TAO Subnet 62)

Hash Rate pod - Bitcoin, AI, DePIN, DeFi

AI
Key Takeaways:
  1. AI Is Moving from Copilot to Pilot. Ridges is betting that the future isn't AI assisting humans, but AI replacing them for specific tasks. Their goal is to make hiring a software engineer as simple as subscribing to a service.
  2. Decentralized Economics Are a Moat. By leveraging Bittensor's incentive layer, Ridges outsources a $15M/year R&D budget to a global pool of competing developers, achieving a cost structure and innovation velocity that centralized players cannot match.
  3. The Breakout Subnet Is Coming. Ridges showcases how a Bittensor subnet can solve real-world business problems—privacy, cost, and quality degradation—to build a product that is not just cheaper, but fundamentally better than its centralized counterparts.
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August 18, 2025

Dylan Patel on GPT-5’s Router Moment, GPUs vs TPUs, Monetization

a16z

AI
Key Takeaways:
  1. From Performance to Profit: The AI industry is pivoting from a war of benchmarks to a game of unit economics. Features like GPT-5’s router signal that cost management and monetization are now as important as model capabilities.
  2. Hardware is a Supply Chain Game: Nvidia’s true moat is its end-to-end control of the supply chain. Competitors aren't just fighting a chip architecture; they're fighting a logistical behemoth that consistently out-executes on everything from memory procurement to time-to-market.
  3. The Grid is the Limit: The biggest check on AI’s expansion is the physical world. The speed at which new power infrastructure and data centers can be built will dictate the pace of AI deployment in the US, creating a major advantage for those who can build faster.
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August 18, 2025

Subnet 56 :: Gradients :: Bittensor End-to-end AI Model Training Suite

Opentensor Foundation

AI
Key Takeaways:
  1. Performance is Proven, Not Promised. Gradients isn't just making claims; it’s delivering benchmark-crushing results, consistently outperforming centralized incumbents and producing state-of-the-art models.
  2. Open Source Unlocks the Enterprise. The shift to verifiable, open-source training scripts is a direct solution to customer data privacy concerns, turning a critical vulnerability into a competitive advantage.
  3. The AutoML Flywheel is Spinning. The network's competitive, tournament-style mechanism creates a self-optimizing system that continuously aggregates the best training techniques, ensuring it remains at the cutting edge.
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August 16, 2025

Google DeepMind Lead Researchers on Genie 3 & the Future of World-Building

a16z

AI
Key Takeaways:
  1. **World Models Are a New Modality.** Genie 3 is not just better video; it's an interactive environment generator. This divergence from passive, cinematic models like Veo signals a new frontier focused on agency and simulation, creating a distinct discipline within generative AI.
  2. **Simulation Is the Key to Embodied AI.** The biggest hurdle for robotics is the lack of realistic training environments. Genie 3 tackles this "sim-to-real" gap head-on, providing a scalable way to train agents on infinite experiences before they ever touch physical hardware.
  3. **Emergent Properties Will Drive the Future.** Key features like spatial memory and nuanced physics weren't explicitly coded but emerged from scaling. The next breakthroughs in world models will come from discovering these unexpected capabilities, not just refining existing ones.
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Crypto Podcasts

October 17, 2025

Is the Crypto Bull Market Over? Gold All-Time Highs, Crypto Whipsaws: Are We Topping or Resetting?

Bankless

Crypto
Key Takeaways:
  1. Leverage is the market's double-edged sword. The $19B flash crash was a cascade failure driven by leverage, not fundamentals. It exposed the fragility of perpetual exchanges and the critical risk of Auto-Deleveraging (ADL) even for sophisticated traders.
  2. Wall Street is tokenizing everything. Larry Fink and BlackRock are building the operating system to move trillions in traditional assets on-chain. This isn't a speculative bet; it's a core strategy to capture a massive, untapped global market.
  3. Infrastructure is maturing, but risks are shifting. While core DeFi protocols proved bulletproof under stress, centralized exchanges and their oracle dependencies remain a systemic weak point, as shown by Binance's API failures and the resulting market chaos.
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October 17, 2025

Global Liquidity Cycle & the Worldwide Rush Into Hard Assets | Weekly Roundup

Forward Guidance

Crypto
Key Takeaways:
  1. Hard Assets Are The Only Exit. Governments must monetize their staggering debt, making monetary inflation hedges like gold and crypto essential. Gold’s recent surge is the canary in the coal mine, signaling a major catch-up move for Bitcoin is imminent.
  2. Forget the Trade War; Watch the Capital War. The real global conflict is financial. The US is building its future on digital dollars (stablecoins), while China is anchoring its system to gold. This divergence will define capital flows for the next decade.
  3. The Bitcoin 4-Year Cycle Is Dead. Treat Bitcoin as a global macro asset driven by liquidity and its relationship with gold. Its recent price consolidation is a sign of distribution from old hands to new institutional players, setting the stage for its next major move.
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October 15, 2025

Kyle Samani Thinks Solana Will Overtake Bitcoin and ETH

The DCo Podcast

Crypto
Key Takeaways:
  1. Utility Trumps Scarcity: The most valuable crypto asset will be the one powering the most economic activity, not simply the one with the most predictable supply.
  2. Solana’s Technical Roadmap is Key: A future state with multiple concurrent block producers will give Solana a decisive advantage in censorship resistance and performance over its rivals.
  3. Bet on SOL to Flip BTC: Samani’s core investment thesis is that as Solana’s real-world adoption becomes undeniable over the next decade, SOL is positioned to become the world’s number one crypto asset.
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October 15, 2025

Crypto's Biggest Liquidation, DAT Strategies, & The Purification Trade | Jeff Park

Forward Guidance

Crypto
Key Takeaways:
  1. Consolidation is Coming: The recent retail wipeout will likely funnel capital into higher-quality assets, with Bitcoin positioned to front-run altcoins in a reversal of typical bull market cycles.
  2. Reframe Debasement as Purification: The simultaneous rise of gold and Bitcoin isn't just a hedge; it's a fundamental repricing of value and a cleansing of a broken financial system, driven by geopolitical strategy.
  3. DATs are Not ETFs: Digital Asset Treasuries offer an active approach to crypto exposure, with smaller players uniquely positioned to capture on-chain alpha that is impossible for mega-holders to access.
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October 14, 2025

LIVE from Digital Asset Summit

Forward Guidance

Crypto
Key Takeaways:
  1. The Crash Was Technical, Not Existential: This wasn't another Luna. It was a liquidity-driven cascade originating from centralized exchanges that wiped out leveraged retail, while DeFi infrastructure proved its mettle. The fundamental bull case remains intact.
  2. Bitcoin is a Different Animal: The stark performance divergence between a resilient Bitcoin and collapsing altcoins is the clearest signal yet that BTC now plays in a different, institutionalized league. The speculative fervor in "useless alts" is dead for the foreseeable future.
  3. Institutions Are Buying the Debasement Story, Not the Dip: Professional investors, insulated by ETFs, completely missed the weekend's volatility. Their focus is unchanged: allocating more capital (now 3-5%) to the "purification trade" as a hedge against unstoppable fiat debasement.
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October 13, 2025

The Most Important Video I’ll Make This Year

Taiki Maeda

Crypto
Key Takeaways:
  1. **The Game Has Changed.** Stop trying to win by spot-buying overvalued altcoins in a market dominated by insiders. The real, sustainable edge is found on-chain through airdrop farming, which allows you to acquire tokens at a low cost basis and sell them to market hype.
  2. **Become an All-Weather Farmer.** Structure your portfolio defensively. A 50%+ stablecoin allocation is not being sidelined; it's a dry powder reserve that allows you to farm, hedge, and survive while others get wiped out. Your upside comes from farming, not from being 100% long.
  3. **Airdrops Are Your Asymmetric Bet.** Treat airdrop points as a call option on the entire crypto market. This allows you to stay risk-off with a large stablecoin position while retaining explosive upside potential if the market runs, creating a win-win scenario.
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