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AI Podcasts

May 30, 2025

Novelty Search May 29, 2025

taostats

AI
Key Takeaways:
  1. Democratization Unleashed: Subnet 17 radically lowers barriers to 3D content creation, empowering indie developers and non-artists.
  2. Gaussian Splats are Hot: This representation is emerging as a key technology for fast, high-fidelity 3D AI, and Subnet 17 is at the forefront.
  3. Web2 Validation is Key: Partnerships like the Unity "verified solution" status signal BitTensor's growing real-world utility and credibility, presenting opportunities for miners and the TAO ecosystem.
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May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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Crypto Podcasts

February 9, 2026

MegaETH Mainnet is Live! — The Next Era of Ethereum Scaling

Bankless

Crypto
Key Takeaways:
  1. The Ethereum scaling narrative is evolving from L2s as mere L1 extensions to specialized, high-performance execution layers. This creates a barbell structure where Ethereum provides core security, and L2s deliver extreme throughput and novel features.
  2. Builders should explore high-performance L2s like MegaETH for applications requiring ultra-low latency and high transaction volumes, especially in gaming, DeFi, and AI agent interactions, where traditional fee models are prohibitive.
  3. MegaETH's mainnet launch, with its technical innovations and unconventional economic and app strategies, signals a new generation of L2s.
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February 8, 2026

The Pro-Quantum Argument w/ Tyler Whittle

The Gwart Show

Crypto
Key Takeaways:
  1. The theoretical certainty of quantum computing, coupled with accelerating engineering breakthroughs, means the digital asset space must proactively build "crypto agility" into its core protocols. This ensures systems can adapt to new cryptographic standards as current ones become obsolete.
  2. Secure your Bitcoin by ensuring it resides in unspent SegWit or P2SH addresses, as these keep your public key hidden until spent. This provides a temporary shield against quantum attacks.
  3. Quantum computing is not a distant threat but a near-term risk with a 20% chance of moving Satoshi's coins by 2030. Ignoring this could lead to a systemic collapse of the "store of value" narrative for Bitcoin and other digital assets, forcing a costly and painful reset.
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February 8, 2026

If Bitcoin doesn't quantum-proof it will be EXPENSIVE

The Gwart Show

Crypto
Key Takeaways:
  1. The crypto industry must shift from viewing quantum as a distant threat to an imminent engineering challenge requiring proactive, coordinated defense.
  2. Ensure any long-term Bitcoin holdings are in SegWit addresses never spent from, as these public keys remain hashed and are currently more resistant to quantum attacks.
  3. A 20% chance of Satoshi's coins moving by 2030, and near certainty by 2035, means delaying upgrades is a multi-billion dollar bet against Bitcoin's core security narrative.
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February 7, 2026

Do We Still Need L2s Now That Ethereum Has Scaled? - Uneasy Money

Unchained

Crypto
Key Takeaways:
  1. Ethereum's L1 scaling redefines L2s from pure throughput solutions to specialized platforms, while AI agents introduce a new, autonomous layer of on-chain activity.
  2. Investigate L2s that offer unique features or cater to specific enterprise needs beyond just low fees.
  3. The future of crypto involves a more performant Ethereum L1, specialized L2s, and a burgeoning agentic economy.
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February 8, 2026

Want to Hire an AI Agent? Check Their Reputation Via ERC-8004

Unchained

Crypto
Key Takeaways:
  1. The rapid rise of autonomous AI agents demands a decentralized trust layer. Blockchains, initially an "internet of money," are now becoming the foundational "internet of trusted agent commerce," providing verifiable identity and reputation essential for multi-agent economies. This shift moves beyond simple payments to establishing a credible, censorship-resistant framework for AI-driven interactions.
  2. Integrate ERC-8004 into agent development. Builders should register their AI agents on ERC-8004 to establish verifiable on-chain identity and reputation, attracting trusted interactions and avoiding future centralized platform fees or censorship.
  3. The future of AI commerce hinges on decentralized trust. ERC-8004 is the foundational primitive for this, ensuring that as AI agents become more sophisticated and transact more value, the underlying infrastructure remains open, fair, and resistant to single points of control. This is a critical piece of the puzzle for anyone building or investing in the agent economy over the next 6-12 months.
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February 8, 2026

Hash Rate - Ep.157 - Mining Bittensor with OpenClaw

Hash Rate Podcast

Crypto
Key Takeaways:
  1. Agentic AI is not just a tool; it's a new layer of abstraction for decentralized networks. It shifts the barrier to entry from deep technical and crypto-specific knowledge to strategic prompting and resource allocation, accelerating network participation and value accrual.
  2. Experiment now. Deploy a hosted agentic AI like OpenClaw (via seafloor.bot) with a small budget to understand its capabilities in a controlled environment. Focus on automating complex setup tasks within decentralized AI protocols like Bittensor to gain firsthand experience before others.
  3. The rise of agentic AI agents will fundamentally reshape how individuals and organizations interact with and profit from decentralized AI. Those who master agent orchestration and "skill" development will capture disproportionate value as these systems become the primary interface for programmable intelligence and capital.
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