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AI Podcasts

May 31, 2025

Varimo: Bittensor Subnets, TaoHash, Dynamic Tao, Privacy Coins, Crypto Investing, AI | Ep. 45

Ventura Labs

AI
Key Takeaways:
  1. Profit-Taking is Paramount: When you've made life-changing money, change your life – don't let paper gains evaporate.
  2. Bet on Bittensor's Talent: The concentration of high-caliber individuals in the Bittensor ecosystem signals immense potential for disruptive innovation.
  3. Follow the AI Capital: AI is poised for significant capital inflow; identify projects with strong fundamentals and teams within this narrative.
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May 30, 2025

SN17 - 404GEN :: Decentralized AI generated 3D assets

Opentensor Foundation

AI
Key Takeaways:
  1. Unlocking Creative Potential: 404GEN radically lowers barriers to 3D content creation, enabling faster iteration and new forms of interactive media previously unfeasible for smaller teams or individuals.
  2. Gaussian Splats are Ascendant: This representation is emerging as a powerful alternative for 3D AI, and 404GEN is at the forefront of its practical application and tooling.
  3. BitTensor's Competitive Edge Shines: The subnet's rapid quality improvement and the innovative ELO validation system highlight BitTensor's power to incentivize and coordinate decentralized intelligence towards state-of-the-art results.
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May 30, 2025

Novelty Search May 29, 2025

taostats

AI
Key Takeaways:
  1. Democratization Unleashed: Subnet 17 radically lowers barriers to 3D content creation, empowering indie developers and non-artists.
  2. Gaussian Splats are Hot: This representation is emerging as a key technology for fast, high-fidelity 3D AI, and Subnet 17 is at the forefront.
  3. Web2 Validation is Key: Partnerships like the Unity "verified solution" status signal BitTensor's growing real-world utility and credibility, presenting opportunities for miners and the TAO ecosystem.
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May 30, 2025

OpenAI, Hyperliquid, and the Internet's Next Growth Phase | Roundup

Bell Curve

AI
Key Takeaways:
  1. AI is the primary internet growth driver; crypto will largely be downstream.
  2. Hyperliquid's app-first L1 strategy and strong fee generation make it a formidable, closely-watched player.
  3. The era of "free money" airdrops is fading, replaced by "skin-in-the-game" token launches and significant institutional capital via treasury vehicles.
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May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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Crypto Podcasts

December 20, 2025

Coinbase Goes All In, JPMorgan Brings Funds Onchain: Weekly Recap

Unchained

Crypto
Key Takeaways:
  1. Tokenization is the Trojan Horse: TradFi isn't just observing; it's actively building on public blockchains. Tokenized real-world assets (RWAs) are the primary vector for institutional adoption.
  2. Governance Matters: For builders, robust and transparent DAO governance is paramount. For investors, scrutinize projects for clear value accrual to token holders and potential conflicts between core teams and DAOs.
  3. Regulatory Nuance: The Fed's policy shift suggests a move towards more nuanced regulation, potentially opening doors for regulated entities to engage with digital assets.
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December 20, 2025

2025 Year In Review Special: AI & Tokenization

The Rollup

Crypto
Key Takeaways:
  1. RWA as a Macro Trend: The tokenization of real-world assets is not a niche but a fundamental shift, attracting significant institutional capital and driving a search for yield beyond traditional instruments.
  2. AI Integration is the Moat: For builders, success in AI hinges on deep integration into existing platforms and workflows, coupled with robust trust and safety mechanisms for autonomous agents.
  3. The Hybrid Future: The market is moving towards centralized frontends (banks, exchanges) offering decentralized, on-chain products. This model bridges user familiarity with crypto-native efficiency, unlocking massive adoption in the next 6-12 months.
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December 20, 2025

Crypto Treasury Stocks Trade Far Below Their Holdings. Is It Time to Buy?

Unchained

Crypto
Key Takeaways:
  1. Strategic Implication: The market is re-evaluating crypto-holding companies, punishing those without clear value-add beyond asset accumulation. The "MNAV of 1" is the expected long-term anchor.
  2. Builder/Investor Note: This is a high-conviction, long-term play, not a quick arbitrage. Investors must conduct deep due diligence on each company's balance sheet, share structure, and operational strategy.
  3. The "So What?": For the next 6-12 months, expect continued volatility and company-specific challenges. The path to MNAV parity will be bumpy, driven by broader market recovery, potential M&A, and individual company execution, not a simple market mechanism.
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December 19, 2025

Why Crypto as a Subculture Is Dying, but Why That's a Good Thing

Unchained

Crypto
Key Takeaways:
  1. Strategic Implication: The "four-year cycle" driven by speculative behavior is likely dead. The industry's maturation will be marked by sustainable business models, not just macro-driven asset prices.
  2. Builder/Investor Note: Prioritize utility and user experience over tokenomics and crypto-native branding. Invest in projects solving real-world problems for a broad audience, not just those chasing the next airdrop.
  3. The "So What?": The next 6-12 months will see a continued shift towards applications that abstract away blockchain complexity, making crypto an invisible, powerful backend for mainstream products.
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December 19, 2025

Why Today’s Economy Serves Assets, Not Workers | Harris Kupperman

Forward Guidance

Crypto
Key Takeaways:
  1. Political Catalyst: A major political shift, likely driven by public anger over economic disparity, is the only force capable of breaking the current feudalistic cycle. This will be obvious when it happens, likely causing a sharp market correction.
  2. Strategic Asset Allocation: Investors should prioritize stores of value (like gold) and seek out hard assets in overlooked emerging/frontier markets. Avoid the AI hardware bubble and identify companies that will leverage AI to cut white-collar costs, rather than those building the infrastructure.
  3. The "So What?": The current economic structure is unsustainable. The growing divide and misallocation of capital will eventually force a re-evaluation of economic priorities. Positioning for this shift means embracing volatility and a long-term, contrarian view, looking beyond the overvalued "approved products" of the current system.
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December 19, 2025

Stablecoins in 2025: The Breakout Year In Review (And What Comes Next...)

The Rollup

Crypto
Key Takeaways:
  1. Strategic Implication: The YBS market is shifting from speculative yield farming to a foundational layer for tokenized finance, driven by institutional interest and RWA integration.
  2. Builder/Investor Note: Prioritize YBS protocols with diversified yield strategies and robust risk management (e.g., first-loss tranches). Builders should focus on RWA infrastructure and sustainable, real-world yield mechanisms.
  3. The "So What?": The convergence of declining traditional rates and maturing RWA tokenization will funnel significant capital into diversified, transparent YBS. Protocols prioritizing these elements will capture the lion's share of the projected $100 billion TVL.
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