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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

February 4, 2026

The Dogecoin Community Might Sh**t me for Saying This...

The DCo Podcast

Crypto
Key Takeaways:
  1. The ongoing global distrust in centralized financial systems fuels a search for decentralized alternatives, yet the crypto market's focus on "store of value" assets like Bitcoin risks missing the original intent of a truly global, fair means of exchange, a gap Dogecoin aims to fill.
  2. Re-evaluate digital asset utility beyond speculative store-of-value narratives, considering projects actively pursuing frictionless, low-cost means of exchange.
  3. The long-term viability of decentralized finance hinges on its ability to deliver practical, everyday utility, not just investment returns. This means projects focused on transactional efficiency could gain significant ground in the coming 6-12 months.
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February 4, 2026

Quadrillions: Stablecoins: We’ve Only Just Begun | Mohamed Afifi

Empire

Crypto
Key Takeaways:
  1. Build infrastructure that simplifies blockchain complexity and stablecoin fragmentation for end-users and enterprises. This is where the next wave of value creation lies.
  2. The global financial system's slowness and cost are directly challenged by programmable stablecoins, moving them from speculative assets to essential, low-cost, high-speed infrastructure.
  3. Stablecoins are moving from a crypto-native tool to a core layer for global finance.
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February 3, 2026

Haonan Li on How Codex is Taking Over The $7 Trillion FX Market

The Rollup

Crypto
Key Takeaways:
  1. As global economies grapple with inflation and inefficient financial systems, capital seeks refuge and utility in digital assets. Onchain FX provides a direct, cost-effective escape route, bypassing legacy intermediaries and offering a superior alternative for cross-border value transfer.
  2. Builders should focus on creating core financial primitives like onchain FX that solve real-world problems with superior economics, rather than chasing speculative narratives or token-driven vanity metrics.
  3. The next 6-12 months will see a continued acceleration of capital into crypto-native financial rails, particularly in emerging markets. Investors and builders should position themselves to capitalize on the structural cost advantages and network effects of onchain FX, which is poised to become a default market for many currency pairs.
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February 4, 2026

Stablecoins Hit $10T Monthly Volume, MetaMask Launches Tokenized Stocks & Galaxy Posts $482M Loss.

The Rollup

Crypto
Key Takeaways:
  1. The "Neo Finance" paradigm is solidifying, blending TradFi assets with DeFi's capital efficiency and transparency. This shift is not just about crypto, but about the future of all finance, with AI agents as a new class of economic actors.
  2. Invest in infrastructure and applications that bridge TradFi and DeFi, focusing on tokenized real-world assets and secure, high-yield stablecoin products. Prioritize platforms offering transparent, risk-managed yield, as institutional capital will flow there.
  3. The market's current volatility masks a profound structural transformation. Builders and investors who focus on creating seamless, capital-efficient, and AI-native financial products will capture the next wave of value, as digital assets become the default for both humans and machines.
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February 3, 2026

From Crypto Legal Advocate to US Senate Candidate | John Deaton

Proof of Coverage Media

Crypto
Key Takeaways:
  1. The erosion of the American dream, fueled by inflationary policies and monopolistic capitalism, is driving a political shift towards candidates who advocate for transparent, common-sense economic policies and modern regulatory clarity for emerging technologies like crypto.
  2. Support political candidates who champion clear, updated regulatory frameworks for digital assets and advocate for increased market competition across industries.
  3. The fight for crypto clarity is now intertwined with broader economic and political reform. Understanding this intersection is crucial for investors and builders navigating a landscape where policy decisions directly impact market viability and individual prosperity over the next 6-12 months.
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February 4, 2026

Will Trump's New Fed Chair Crash Markets? | Joseph Wang

Forward Guidance

Crypto
Key Takeaways:
  1. Politically influenced central banking is returning, making monetary policy an electoral tool. Fed decisions will reflect political priorities, potentially leading to aggressive rate cuts.
  2. Re-evaluate portfolio sensitivity to political intervention. Position for lower long-term rates, but prepare for increased market volatility.
  3. The incoming Fed chair signals a re-alignment of monetary policy with executive branch goals. Expect policy to prioritize affordability and electoral success.
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