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AI Podcasts

May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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May 25, 2025

How Endless Debt Became America's Culture

Forward Guidance

AI
Key Takeaways:
  1. **Debt is Destiny:** America's fiscal irresponsibility and cultural embrace of debt ensure ongoing money printing and inflation, making currency debasement a near certainty.
  2. **The One True Trade:** Forget complex analytics; the primary goal is preserving purchasing power. This means owning store-of-value assets like Bitcoin and gold, which are positioned to thrive.
  3. **AI Accelerates the Crisis:** Artificial intelligence will not only disrupt labor markets but also intensify the debt crisis by devaluing traditional education and fueling calls for more government relief.
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Crypto Podcasts

November 14, 2025

Is The Crypto Bull Market Already Over?

Bankless

Crypto
Key Takeaways:
  1. The Fee Switch Is On. Uniswap's pivot to real-yield tokenomics is a watershed moment. Expect other DeFi protocols to follow, finally aligning token value with protocol success and rewarding long-term holders over mercenaries.
  2. Onshore ICOs Are Back. Coinbase’s new token sales platform for US retail is a massive signal that the industry believes the regulatory tide has turned. This could unlock a new wave of capital and mainstream participation.
  3. Privacy Is A High-Stakes Gamble. While the market is rewarding privacy tokens, the 5-year prison sentence for a wallet developer is a brutal reminder of the risks. Until clear rules are established, building privacy tools in the US remains legally treacherous.
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November 13, 2025

Hash Rate - Ep 144 - SCORE Subnet 44

Hash Rate pod - Bittensor $TAO & Subnets

Crypto
Key Takeaways:
  1. Privacy is Paramount. SCORE’s use of TEEs for a private data track is the key that unlocks enterprise adoption, proving that decentralized networks can handle sensitive information securely.
  2. The 1/10th Price Model Wins. Leveraging Bittensor’s incentive structure allows subnets to radically undercut legacy competitors on price without sacrificing quality, opening up previously inaccessible markets.
  3. Tie Rewards to Revenue. The most sustainable tokenomic model directly links network emissions to real-world cash flow, ensuring the subnet's economy is grounded in tangible business success, not just speculation.
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November 12, 2025

Lean Ethereum: How L1 Reaches 10k TPS | Beast Mode & Fort Mode

Bankless

Crypto
Key Takeaways:
  1. **Ethereum's New Offense:** Lean Ethereum marks a strategic pivot from a defensive, decentralization-first posture to an offensive "Beast Mode," targeting 10,000 TPS on L1—a 500x increase—to become the settlement layer for all of finance.
  2. **The Validator Role is Evolving:** The future validator will verify tiny cryptographic proofs on cheap hardware (like a smartphone), not execute massive blocks. This radical shift, enabled by ZK-EVMs, simultaneously boosts scale and decentralization.
  3. **L1 Scaling is Now Possible Without Centralization:** Unlike competitors who scale by using powerful hardware in data centers, Ethereum's use of SNARKs allows it to scale L1 while *decreasing* hardware requirements, reinforcing its core value proposition.
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November 11, 2025

Hash Rate - Ep 142 - Targon (Subnet 4) Update

Hash Rate pod - Bittensor $TAO & Subnets

Crypto
Key Takeaways:
  1. Proof-of-Work Is Now Verifiable. Targon’s TVM introduces a new primitive for Bittensor, making "proof of useful work" cryptographically verifiable. This technology could become the network’s standard, eliminating fraud and ensuring capital flows to genuine contributors.
  2. The Internal Economy Is the Main Event. The focus has shifted from attracting external enterprise clients to building a robust, circular economy within Bittensor. The success of one subnet directly benefits others, creating a powerful collaborative incentive structure.
  3. Bittensor Is Playing the Long Game Against Centralized AI. The strategy is clear: build a resilient, hyper-efficient decentralized alternative while centralized AI players burn through unsustainable amounts of capital. When the market turns, Bittensor aims to be the "black hole" that absorbs the distressed compute assets.
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November 7, 2025

Finding Alpha In Crypto, Mamdani Wins & The AI Gold Rush | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. **Ditch the Alts, Buy the Adopters.** The most compelling risk/reward is no longer in L1 tokens but in publicly traded companies effectively integrating blockchain. Think Stripe and Robinhood, not the 25th-largest token on CoinMarketCap.
  2. **Follow the Gamble.** The "gambling energy" from disillusioned younger generations is a powerful market force. That capital has pivoted from crypto to AI. The best trades lie in narratives that capture this retail attention.
  3. **Conviction Over Diversification.** In a market with no consensus, holding a portfolio of "pretty good" assets is a losing strategy. Raise cash by cutting low-conviction plays and concentrate firepower in your highest-conviction ideas.
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November 7, 2025

Bull Market or Fakeout Top? Haseeb’s Crypto Cycle Take

Bankless

Crypto
Key Takeaways:
  1. AI Is The Only Game In Town: The crypto market is currently a passenger in a macro environment dictated by AI. Until that capital rotation shifts, crypto will likely remain highly correlated and susceptible to sell-offs when equities show weakness.
  2. Bitcoin’s Handover Is Bullish: Don't mistake consolidation for a bear market. Bitcoin is undergoing a healthy ownership transfer from early believers to new institutions, building a stronger, deeper foundation for its next leg up.
  3. Decentralization Is About Coercion, Not Paralysis: The ability of a chain’s validators to collectively intervene in a catastrophic hack is a feature, not a bug. True decentralization is measured by a network's ability to resist external pressure, not its inability to make collective decisions.
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