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AI Podcasts

December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Strategic Shift: AI-driven kernel generation is not replacing human genius but augmenting it, allowing experts to focus on novel breakthroughs while AI automates the application of known optimizations across a complex hardware landscape.
  2. Builder/Investor Note: Focus on robust validation and hardware-in-the-loop systems. Claims of "AI inventing new algorithms" in this domain are premature. The real value is in automating the "bag of tricks" for heterogeneous compute.
  3. The "So What?": This technology is critical for scaling agentic AI workloads. Expect significant investment in tools that abstract hardware complexity and enable efficient, automated optimization, driving down the cost of AI inference in the next 6-12 months.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Semantic Shift: The future of AI in code moves from text generation to deep semantic understanding and execution simulation.
  2. Builder Opportunity: Develop next-generation debugging tools and code agents that leverage internal simulation for faster, more efficient development cycles.
  3. Investor Focus: Prioritize models and platforms that demonstrate explicit execution modeling, as this capability will redefine software development and create new market leaders.
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December 17, 2025

AI Kernel Generation: What's working, what's not, what's next – Natalie Serrino, Gimlet Labs

AI Engineer

AI
Key Takeaways:
  1. Infrastructure Shift: AI-driven kernel optimization addresses a critical bottleneck in scaling AI compute, enabling more efficient use of diverse hardware.
  2. Builder/Investor Note: Focus on solutions with robust, hardware-verified performance metrics and a clear human-in-the-loop strategy. AI is a powerful tool for automating optimization, not a magic bullet for novel algorithmic breakthroughs.
  3. The "So What?": This technology frees expert engineers from tedious optimization, allowing them to focus on higher-level research and truly innovative algorithmic design, accelerating the pace of AI development in the next 6-12 months.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. Effective crime reduction requires a shift from reactive punishment to proactive, intelligence-driven deterrence, making it highly probable for criminals to be caught.
  2. The market for AI-powered public safety technology, particularly solutions that integrate data for precision and accountability, presents a significant opportunity. Public-private partnerships are a key funding mechanism.
  3. Over the next 6-12 months, expect to see more cities adopt advanced surveillance and AI tools, driven by private funding, as they seek to improve safety and address staffing shortages without resorting to ineffective, broad-stroke policies.
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December 17, 2025

“How We Can Eliminate Crime” | Ben Horowitz and Garrett Langley

a16z

AI
Key Takeaways:
  1. The Future of Policing is Intelligent: Integrating AI, drones, and smart cameras creates a precise, accountable, and safer policing model for both officers and communities.
  2. Invest in the "How": Builders and investors should focus on technologies that enhance certainty of capture, streamline judicial processes, and support public-private partnerships to modernize urban safety infrastructure.
  3. Safety Fuels Mobility: Eliminating crime is not just about law enforcement; it's about restoring the fundamental safety required for economic mobility and a functional society.
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December 16, 2025

Build reliable AI agents using W&B Training

Weights & Biases

AI
Key Takeaways:
  1. The democratization of RL fine-tuning will accelerate the development and deployment of more reliable and sophisticated AI agents across industries.
  2. Builders should explore open-source LLMs combined with RL fine-tuning as a cost-effective strategy to achieve specific performance benchmarks, especially where latency and cost are critical.
  3. Platforms abstracting infrastructure complexity and providing integrated tooling for the entire AI development lifecycle are crucial for the next phase of AI agent deployment.
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December 16, 2025

Build reliable AI agents using W&B Training

Weights & Biases

AI
Key Takeaways:
  1. The democratization of RL for LLMs will accelerate the deployment of more reliable and sophisticated AI agents across industries.
  2. Builders should move beyond basic prompt engineering and RAG. RL fine-tuning, now accessible via W&B Serverless RL, is a critical next step for high-stakes agentic applications.
  3. For the next 6-12 months, expect a surge in production-grade AI agents, with open-source models increasingly closing the performance gap with proprietary alternatives through advanced fine-tuning.
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December 16, 2025

Your Support Team Should Ship Code – Lisa Orr, Zapier

AI Engineer

AI
Key Takeaways:
  1. Workflow Automation is the New Frontier: The real value of AI in developer tools comes from orchestrating entire workflows, not just individual point solutions.
  2. Embed for Adoption: Tools must integrate seamlessly into existing workflows and IDEs (like Cursor) to achieve high usage.
  3. Support as a Code-Shipping Powerhouse: Empowering non-traditional roles with AI-driven code generation leverages their unique, real-time context, creating significant operational leverage.
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December 16, 2025

Your Support Team Should Ship Code – Lisa Orr, Zapier

AI Engineer

AI
Key Takeaways:
  1. Strategic Implication: Companies integrating AI-driven code generation into non-engineering roles will see significant efficiency gains and improved product reliability.
  2. Builder/Investor Note: Focus on building AI tools that deeply embed into existing workflows. Orchestration of multiple AI tools into an agent-like system is key for adoption and value.
  3. The "So What?": The next 6-12 months will see a redefinition of "support" from reactive reporting to proactive, code-shipping problem-solving, unlocking new talent pools and accelerating development cycles.
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Crypto Podcasts

November 5, 2025

Why the Crypto Markets Seem Down Bad as Bitcoin Dips Below $100K

Unchained

Crypto
Key Takeaways:
  1. Despite the brutal sentiment, both speakers remain bullish, predicting a sharp reversal and a new all-time high for Bitcoin by the end of the year once macro clarity emerges.
  2. Macro is King. Bitcoin's fate is now tied to the broader economy. Forget four-year cycles; the key catalyst is a resolution to the government shutdown, which could unlock pent-up energy in the market.
  3. The Treasury Trade is Toast. The era of companies boosting their stock by simply buying Bitcoin is over. Expect a painful shakeout as the market demands real utility and revenue, leading to more forced selling.
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November 5, 2025

x402: The Key to Internet Money, Micropayments & The AI Agent Economy

Bankless

Crypto
Key Takeaways:
  1. The Internet Gets Its Native Wallet. x402 uses crypto to finally fulfill the internet's original vision of direct, peer-to-server payments, unlocking an economy of micropayments for everything from accessing an article to running an AI model.
  2. The Ad-Supported Web Is Obsolete. AI agents that retrieve information without viewing ads are killing the web's 20-year-old business model. x402 provides the new economic rails for a pay-per-use internet where value is exchanged for resources, not attention.
  3. Build Composable Money Legos. The biggest opportunity lies in creating simple, single-purpose APIs that agents can easily discover and compose. Think of it as building for the App Store of the emerging AI agent economy.
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November 5, 2025

Play to Earn Crypto Games: $65B Opportunity | Open Game Protocol & Zynga Founder

The DCo Podcast

Crypto
Key Takeaways:
  1. Distribution is the prize, not payments. The real money in gaming isn't in payment rails, which are being competed down to zero. The scarcest and most valuable asset is user attention, and Open Game Protocol is designed to monetize distribution.
  2. Decouple to survive. Tying a single game to a single token creates a fatal dependency. A flexible, many-to-many protocol allows ecosystems to thrive by spreading risk and aligning incentives across multiple games and communities.
  3. Content abundance requires new discovery. As AI makes game creation cheap and fast, the bottleneck shifts from production to discovery. Integrating games directly into high-intent surfaces like crypto wallets creates a powerful, non-advertising-based discovery channel.
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November 5, 2025

The Next Chapter For Blockworks | Empire

Forward Guidance

Crypto
Key Takeaways:
  1. Focus or Fade. As the industry matures, companies must shed non-core business units to become world-class at one thing. For Blockworks, that's data, not news.
  2. Buy the Theme. Public market investors will pay a massive premium for the only stock representing a major crypto trend (e.g., Securitize for tokenization), often making it a better trade than trying to pick winners among underlying assets.
  3. Growth is Subsidized. Major L1/L2 foundations are actively paying for enterprise adoption (e.g., Solana and Western Union). This is a standard business practice to kickstart network effects, but the long-term ROI remains unproven.
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November 4, 2025

Bits + Bips LIVE

Unchained

Crypto
Key Takeaways:
  1. **Follow the Suits, Not the Shouts.** The market’s real signal is the massive disconnect between gloomy retail sentiment on social media and the unprecedented optimism from financial advisors and institutional platforms.
  2. **Distribution is the New Kingmaker.** From Ripple buying prime brokerages to Tether leveraging its global south dominance, the primary battle is for distribution channels. The technical "best" solution is irrelevant if it can't reach users.
  3. **Regulation Will Be a Slow Grind, Not a Big Bang.** Comprehensive crypto legislation is politically gridlocked. The industry’s integration into legacy finance will continue brick-by-brick through regulated products like ETFs, not sweeping bills from Congress.
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November 4, 2025

LIVE: BOCCACCIO EXPLAINING TO HIS WIFE THAT THEY LOST IT ALL | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. Tokenized Funds Are a Real-World Unlock. Unlike many crypto narratives, bringing funds on-chain solves a tangible, expensive problem in traditional finance, creating massive operational efficiencies and new financial primitives.
  2. The Bitcoin Holder Base Is Shifting. The ongoing "Bitcoin IPO" via ETFs means the asset is moving from the hands of early adopters to institutional portfolios. This structural shift will define its future trajectory.
  3. Cash Is Your Best Hedge. In a market with fewer winners, holding cash is a strategic imperative. It prevents forced liquidation and provides the dry powder needed to seize high-conviction opportunities as they arise.
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