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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

February 24, 2025

Where Does Crypto Go From Here? | EP 71

Good Game Podcast

Crypto
AI
Infrastructure

Key Takeaways:

  • 1. Focus on Financial Utility: Crypto's strongest and most sustainable applications remain within the financial sector, emphasizing the need for robust, revenue-generating projects over speculative tokens.
  • 2. Leverage AI for Innovation: Startups that effectively integrate AI to solve real-world problems, particularly in personalized applications, are poised for significant growth and competitive advantage.
  • 3. Embrace Tokenization: The future of equity and capital formation lies in tokenizing shares and streamlining IPO processes on-chain, presenting a transformative opportunity for startups and investors alike.
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February 24, 2025

Solana’s Vibe Shift, Restaking, and Yapping About Kaito | Ian Unsworth

0xResearch

Crypto
DeFi
AI

Key Takeaways:

  • :
  • 1. Solana’s Dependence on Meme Coins: While meme coins drive substantial revenue for Solana, they also introduce significant vulnerabilities amid changing market sentiments and regulatory pressures.
  • 2. Staking Yield Dynamics: Proposed reductions in staking yields are unlikely to trigger mass unstaking but will push the ecosystem towards more liquid and innovative staking solutions.
  • 3. Kaido’s Tokenomics Potential: Emerging platforms like Kaido offer novel tokenomics and AI integration, presenting new opportunities and challenges in monetizing user engagement and attention.
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February 24, 2025

Memes are Dead, Long Live the Memes | Nick Tomaino

Empire

Crypto
DeFi

Key Takeaways:

  • :
  • 1. Meme coins, while initially promising, often exploit retail investors through pump and dump schemes, necessitating a wary approach.
  • 2. Investing in crypto requires a long-term vision, focusing on meaningful projects and founders committed to sustained growth over fleeting gains.
  • 3. Stablecoins are pivotal in maintaining the US dollar's global influence and are set to grow with increasing adoption and regulatory support.
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February 24, 2025

How Sapien Lets Anyone Earn by Creating Datasets

Outpost | Crypto AI

AI
Crypto
Infrastructure

Key Takeaways:

  • 1. Decentralized data labeling can significantly reduce costs while enhancing data quality through global expert networks.
  • 2. The synergy between crypto and AI unlocks new possibilities for scalable and efficient AI model training.
  • 3. Proprietary, purpose-built datasets are becoming essential for enterprises to maintain a competitive edge in AI development.
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February 23, 2025

Crypto Circus Never Ends: Hacks, Grifts, and Kanye’s Coin?

Unchained

Crypto
DeFi

Key Takeaways:

  • :
  • 1. Major Hacks Undermine Trust: The Bybit hack exemplifies the vulnerabilities in crypto security and the sophisticated methods of state-affiliated hackers.
  • 2. Insider Scandals Expose Systemic Flaws: The Libra scandal reveals deep-seated issues in meme coin launches, highlighting the need for greater transparency and regulation.
  • 3. Regulatory Shifts Offer Hope: Positive moves by the SEC and the CFTC signal a more supportive regulatory landscape, encouraging legitimate crypto innovation.
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February 21, 2025

Is Hashflow The Next Hyperliquid?

The Rollup

DeFi
Crypto
Infrastructure

Key Takeaways:

  • 1. ZK Technology is Transformative: Zero-Knowledge proofs are not only scalable and secure but are also finding essential applications in decentralized finance, particularly in proving exchange solvency without sacrificing performance.
  • 2. Hashflow Leads with Innovation: By leveraging ZK, Hashflow is positioned as a frontrunner in creating high-performance, secure exchanges that offer a user-friendly experience, potentially setting a new standard for the industry.
  • 3. Real-Time Proving is the Future: The advancement towards real-time proving will revolutionize cross-chain interactions and user experiences, making decentralized exchanges as fast and reliable as their centralized counterparts.
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