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AI Podcasts

February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The AI industry is moving from specialized models to unified, multimodal systems, driven by a full-stack approach that integrates hardware, software, and organizational strategy. This means generalist models will increasingly dominate, with specialized knowledge delivered via retrieval or modular extensions.
  2. Invest in developing "crisp specification" skills for interacting with AI agents, whether for coding or complex problem-solving. This will be a core competency for maximizing AI productivity and ensuring desired outcomes.
  3. The race for AI dominance is a multi-dimensional chess match where hardware efficiency, model distillation, and organizational alignment are as critical as raw compute. Expect personalized, low-latency AI to redefine productivity and interaction within the next 6-12 months.
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February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. The Macro Shift: AI in biology shifts from predictive analysis to *generative design* of novel molecules. This, like LLMs for text, democratizes new therapeutics, transforming drug discovery from slow, empirical to rapid, AI-accelerated design.
  2. The Tactical Edge: Invest in platforms abstracting computational complexity. Prioritize tools offering robust, validated design across diverse molecular modalities, with scalable infrastructure and intuitive interfaces, to accelerate R&D.
  3. The Bottom Line: Designing novel, high-affinity molecules is no longer a distant dream. Over the next 6-12 months, companies integrating generative AI platforms like Boltz Lab will gain a significant competitive advantage, reducing time and cost in identifying promising therapeutic candidates.
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February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. The Macro Shift: AI is transitioning from analyzing existing biological data to actively creating new biological entities, accelerating the pace of therapeutic discovery. This means a future where drug design is less about trial-and-error and more about intelligent, targeted generation.
  2. The Tactical Edge: Invest in or build platforms that abstract away the computational complexity of generative AI for molecular design, focusing on user-friendly interfaces, robust infrastructure, and rigorous experimental validation. This approach will capture the value of AI for non-computational scientists.
  3. The Bottom Line: The ability to design novel proteins and small molecules with AI, validated in the lab, is no longer a distant dream. Companies like Boltz are making this a reality, creating a new class of tools that will fundamentally reshape drug development pipelines over the next 6-12 months, driving unprecedented efficiency and innovation.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The relentless pursuit of AI capability is increasingly intertwined with the economics of compute, forcing a strategic pivot towards hardware-software co-design and efficient model deployment to make frontier AI universally accessible.
  2. Prioritize low-latency AI interactions for agentic workflows, leveraging smaller, distilled models for rapid iteration and complex task decomposition.
  3. The next 6-12 months will see a significant acceleration in personalized AI experiences and agent-driven software development, powered by advancements in hardware efficiency and the ability to crisply define tasks for increasingly capable models.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The AI industry is moving towards unified, multimodal models that generalize across tasks, replacing specialized models. This transition, driven by scaling and distillation, means general-purpose AI will increasingly handle complex, diverse problems.
  2. Prioritize building systems that leverage low-latency, cost-effective "flash" models for multi-turn interactions and agentic workflows. This allows for rapid iteration and human-in-the-loop correction, which can outperform single, large, expensive model calls.
  3. The future of AI is not just about raw capability, but about the efficient delivery of that capability. Investing in hardware-aware model design and distillation techniques will be key to achieving truly pervasive and affordable AI applications over the next 6-12 months.
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February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. The open-source movement is now extending into complex biological AI, challenging proprietary giants and accelerating scientific progress.
  2. Invest in platforms that abstract away the computational complexity of running large-scale generative AI models for molecular design.
  3. The ability to design novel proteins and small molecules with AI is here, but it's a tool, not a magic bullet.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. Specialized AI models are yielding to unified, multimodal architectures that generalize across diverse tasks. This shift, coupled with hardware-software co-design, makes advanced AI capabilities more powerful and economically viable.
  2. Prioritize low-latency, multi-turn interactions with AI agents over single, complex prompts. This iterative approach, especially with faster "Flash" models, allows for more effective human-AI collaboration and better quality outputs.
  3. The future of AI demands relentless pursuit of both frontier capabilities and extreme efficiency. Builders and investors should focus on infrastructure and model architectures enabling this dual strategy, particularly those leveraging distillation and multimodal input.
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February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. Open-source AI is driving a fundamental shift in drug discovery, moving from predicting existing structures to computationally generating novel therapeutic candidates. This democratizes access, accelerating scientific discovery.
  2. Invest in platforms abstracting computational and architectural complexity, offering accessible, high-throughput design. Prioritize solutions demonstrating robust, multi-target experimental validation.
  3. The future of drug discovery is generative. Companies bridging cutting-edge AI with user-friendly, scalable infrastructure and rigorous validation will capture significant value, empowering scientists to design next generation of therapeutics.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The relentless pursuit of AI capability is increasingly intertwined with the engineering discipline of cost-effective, low-latency deployment, driving a full-stack co-evolution of hardware, algorithms, and model architectures.
  2. Prioritize investments in AI systems that excel at distillation and efficient data movement, as these are the keys to scaling advanced capabilities from frontier research to mass-market applications.
  3. The next 6-12 months will see a significant push towards personalized, multimodal AI and highly efficient, low-latency models, fundamentally changing how we interact with and build on AI, making crisp prompt engineering a core skill.
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Crypto Podcasts

February 20, 2025

Kaito And The Massive Crypto AI Trend Nobody Is Talking About

Bankless

Crypto
AI
DeFi

Key Takeaways:

  • 1. Shift to Utility-Driven Crypto: The decline of meme coins signals a maturation of the crypto market, with a strong pivot towards innovative, utility-focused projects, especially in AI.
  • 2. AI Models Are Accelerating Innovation: Rapid advancements in AI, exemplified by models like Grock 3, are challenging established leaders and driving the next wave of crypto innovation.
  • 3. Kaido’s KITO Token is a Game-Changer: The launch of Kaido’s KITO token represents a significant opportunity for investors and developers, as it aims to create a robust decentralized data layer critical for the advancement of AI agents in crypto.
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February 20, 2025

Why BlackRock’s BUIDL Fund is Going Multichain

The Rollup

Crypto
DeFi

Key Takeaways:

  • 1. Multichain Strategy is Crucial: Embracing interoperability across multiple blockchains significantly enhances the liquidity and utility of tokenized assets, positioning funds like BlackRock’s BUIDL for broader market integration and success.
  • 2. Regulatory Clarity Drives Innovation: Clear and supportive regulatory frameworks are essential for the continued growth and adoption of tokenized real-world assets, ensuring investor protection while fostering technological advancement.
  • 3. Institutional Adoption is Accelerating: The rapid influx of institutional capital and interest in tokenized assets highlights a pivotal shift towards mainstream acceptance, presenting lucrative opportunities for investors and innovators alike.
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February 19, 2025

Breaking Crypto's Privacy Deadlock with Primus

The Rollup

Crypto
AI
Infrastructure

Key Takeaways:

  • 1. Primus is revolutionizing crypto middleware with advanced ZK technologies, enabling secure, privacy-preserving applications essential for regulatory compliance.
  • 2. Investment strategies are shifting towards application-layer projects, offering higher engagement and returns by addressing real-world use cases in fintech and AI.
  • 3. Embedding compliance into blockchain protocols through ZK proofs is crucial for broader adoption, providing a seamless integration of privacy and regulatory requirements.
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February 17, 2025

Justin Drake & Federico Carrone on Ethereum’s Native Rollup Roadmap

The Rollup

Crypto
Infrastructure

Key Takeaways:

  • 1. Ethereum’s native rollups are set to revolutionize scalability, offering enhanced transaction speeds while maintaining security.
  • 2. Security remains a cornerstone in the development of native rollups, ensuring the integrity and reliability of the Ethereum network.
  • 3. The economic benefits of native rollups, including reduced transaction fees, are poised to drive greater adoption among developers, users, and investors.
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February 17, 2025

Hester Peirce's Crypto Task Force: A New Era for Regulation?

Bankless

Crypto
Others

Key Takeaways:

  • 1. Collaborative Regulation: The SEC’s new approach under Hester Peirce aims to foster innovation through collaboration rather than confrontation, creating a more supportive environment for crypto development.
  • 2. Increased Custodian Participation: The repeal of SAB 121 unlocks opportunities for traditional financial institutions to engage in crypto custody, potentially leading to greater market stability and trust.
  • 3. Encouraging Transparency and Compliance: Tools like no-action letters and safe harbor mechanisms are designed to promote transparency and voluntary compliance, helping to legitimize the crypto industry while protecting investors.
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February 16, 2025

Mira Network: Why AI Agents Can't Be Trusted Yet with Karan Sirdesai

Outpost | Crypto AI

AI
Crypto
Infrastructure

Key Takeaways:

  • 1. Mirror Network's decentralized verification drastically reduces AI hallucinations, enhancing trust in autonomous AI systems.
  • 2. The fusion of crypto’s staking and slashing mechanisms provides a scalable and secure framework for AI reliability.
  • 3. Mirror’s wide-ranging applications across multiple industries underscore its significant growth potential and investment appeal.
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