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AI Podcasts

February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The AI industry is moving from specialized models to unified, multimodal systems, driven by a full-stack approach that integrates hardware, software, and organizational strategy. This means generalist models will increasingly dominate, with specialized knowledge delivered via retrieval or modular extensions.
  2. Invest in developing "crisp specification" skills for interacting with AI agents, whether for coding or complex problem-solving. This will be a core competency for maximizing AI productivity and ensuring desired outcomes.
  3. The race for AI dominance is a multi-dimensional chess match where hardware efficiency, model distillation, and organizational alignment are as critical as raw compute. Expect personalized, low-latency AI to redefine productivity and interaction within the next 6-12 months.
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February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. The Macro Shift: AI in biology shifts from predictive analysis to *generative design* of novel molecules. This, like LLMs for text, democratizes new therapeutics, transforming drug discovery from slow, empirical to rapid, AI-accelerated design.
  2. The Tactical Edge: Invest in platforms abstracting computational complexity. Prioritize tools offering robust, validated design across diverse molecular modalities, with scalable infrastructure and intuitive interfaces, to accelerate R&D.
  3. The Bottom Line: Designing novel, high-affinity molecules is no longer a distant dream. Over the next 6-12 months, companies integrating generative AI platforms like Boltz Lab will gain a significant competitive advantage, reducing time and cost in identifying promising therapeutic candidates.
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February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. The Macro Shift: AI is transitioning from analyzing existing biological data to actively creating new biological entities, accelerating the pace of therapeutic discovery. This means a future where drug design is less about trial-and-error and more about intelligent, targeted generation.
  2. The Tactical Edge: Invest in or build platforms that abstract away the computational complexity of generative AI for molecular design, focusing on user-friendly interfaces, robust infrastructure, and rigorous experimental validation. This approach will capture the value of AI for non-computational scientists.
  3. The Bottom Line: The ability to design novel proteins and small molecules with AI, validated in the lab, is no longer a distant dream. Companies like Boltz are making this a reality, creating a new class of tools that will fundamentally reshape drug development pipelines over the next 6-12 months, driving unprecedented efficiency and innovation.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The relentless pursuit of AI capability is increasingly intertwined with the economics of compute, forcing a strategic pivot towards hardware-software co-design and efficient model deployment to make frontier AI universally accessible.
  2. Prioritize low-latency AI interactions for agentic workflows, leveraging smaller, distilled models for rapid iteration and complex task decomposition.
  3. The next 6-12 months will see a significant acceleration in personalized AI experiences and agent-driven software development, powered by advancements in hardware efficiency and the ability to crisply define tasks for increasingly capable models.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The AI industry is moving towards unified, multimodal models that generalize across tasks, replacing specialized models. This transition, driven by scaling and distillation, means general-purpose AI will increasingly handle complex, diverse problems.
  2. Prioritize building systems that leverage low-latency, cost-effective "flash" models for multi-turn interactions and agentic workflows. This allows for rapid iteration and human-in-the-loop correction, which can outperform single, large, expensive model calls.
  3. The future of AI is not just about raw capability, but about the efficient delivery of that capability. Investing in hardware-aware model design and distillation techniques will be key to achieving truly pervasive and affordable AI applications over the next 6-12 months.
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February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. The open-source movement is now extending into complex biological AI, challenging proprietary giants and accelerating scientific progress.
  2. Invest in platforms that abstract away the computational complexity of running large-scale generative AI models for molecular design.
  3. The ability to design novel proteins and small molecules with AI is here, but it's a tool, not a magic bullet.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. Specialized AI models are yielding to unified, multimodal architectures that generalize across diverse tasks. This shift, coupled with hardware-software co-design, makes advanced AI capabilities more powerful and economically viable.
  2. Prioritize low-latency, multi-turn interactions with AI agents over single, complex prompts. This iterative approach, especially with faster "Flash" models, allows for more effective human-AI collaboration and better quality outputs.
  3. The future of AI demands relentless pursuit of both frontier capabilities and extreme efficiency. Builders and investors should focus on infrastructure and model architectures enabling this dual strategy, particularly those leveraging distillation and multimodal input.
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February 12, 2026

🔬Generating Molecules, Not Just Models

Latent Space

AI
Key Takeaways:
  1. Open-source AI is driving a fundamental shift in drug discovery, moving from predicting existing structures to computationally generating novel therapeutic candidates. This democratizes access, accelerating scientific discovery.
  2. Invest in platforms abstracting computational and architectural complexity, offering accessible, high-throughput design. Prioritize solutions demonstrating robust, multi-target experimental validation.
  3. The future of drug discovery is generative. Companies bridging cutting-edge AI with user-friendly, scalable infrastructure and rigorous validation will capture significant value, empowering scientists to design next generation of therapeutics.
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February 12, 2026

Owning the AI Pareto Frontier — Jeff Dean

Latent Space

AI
Key Takeaways:
  1. The relentless pursuit of AI capability is increasingly intertwined with the engineering discipline of cost-effective, low-latency deployment, driving a full-stack co-evolution of hardware, algorithms, and model architectures.
  2. Prioritize investments in AI systems that excel at distillation and efficient data movement, as these are the keys to scaling advanced capabilities from frontier research to mass-market applications.
  3. The next 6-12 months will see a significant push towards personalized, multimodal AI and highly efficient, low-latency models, fundamentally changing how we interact with and build on AI, making crisp prompt engineering a core skill.
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Crypto Podcasts

February 21, 2025

Is Hashflow The Next Hyperliquid?

The Rollup

DeFi
Crypto
Infrastructure

Key Takeaways:

  • 1. ZK Technology is Transformative: Zero-Knowledge proofs are not only scalable and secure but are also finding essential applications in decentralized finance, particularly in proving exchange solvency without sacrificing performance.
  • 2. Hashflow Leads with Innovation: By leveraging ZK, Hashflow is positioned as a frontrunner in creating high-performance, secure exchanges that offer a user-friendly experience, potentially setting a new standard for the industry.
  • 3. Real-Time Proving is the Future: The advancement towards real-time proving will revolutionize cross-chain interactions and user experiences, making decentralized exchanges as fast and reliable as their centralized counterparts.
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February 21, 2025

$LIBRA Memecoin Scandal Rocks Argentina & The U.S. Fed’s Next Move! Pivot?

Bankless

Crypto
Others

Key Takeaways

  • Heightened Fraud Risks: The $LIBRA scandal underscores the perpetual risk of manipulation in memecoin markets, urging investors to exercise extreme caution.
  • Evolving Airdrop Strategies: Airdrops are becoming more sophisticated, but misalignment between expectations and reality continues to challenge their effectiveness.
  • Regulatory Balance Needed: While the SEC’s efforts to curb fraud are crucial, the crypto industry must develop robust self-regulation to complement external oversight

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February 21, 2025

Monetary Properties of SOL and ETH

The Rollup

Crypto
DeFi

Key Takeaways

  • Ethereum Outshines Solana: Ethereum’s superior decentralization and monetary properties make it a more reliable asset compared to Solana.
  • Decentralization is Crucial: The degree of decentralization directly impacts an asset’s stability and future predictability, influencing investor confidence.
  • Bitcoin’s Influence Remains Strong: Despite Ethereum’s strengths, Bitcoin’s dominance sets the benchmark for decentralized digital assets, shaping the competitive landscape for other cryptocurrencies.

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February 21, 2025

A New Era For Crypto In The U.S | Rebecca Rettig

Lightspeed

Crypto
DeFi

Key Takeaways:

  • 1. Regulatory Clarity is Crucial: Effective engagement with the SEC can pave the way for more robust and compliant crypto innovations.
  • 2. Decentralization Enhances Stability: Solana’s efforts to decentralize through Jeto Labs contribute to a more resilient and trustworthy network.
  • 3. DeFi as a Game-Changer: The growth of DeFi offers unprecedented opportunities for financial autonomy and market efficiency, driving future crypto adoption.
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February 21, 2025

The Friday Podcast | Sonic and Berachain Breathe Life Into Crypto After LIBRA Memecoin Disaster

blocmates.

Crypto
Others

Key Takeaways:

  • 1. LIBRA’s collapse underscores the critical need for transparency and ethical practices in meme coin launches to restore investor trust.
  • 2. Innovative projects like Sonic and Berachain are crucial in revitalizing the crypto market, demonstrating strong recovery and growth potential.
  • 3. Utility-driven tools such as Kato are essential for fostering a more transparent and authentic crypto community, paving the way for sustainable development.
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February 20, 2025

Bitcoin’s Institutional Bid, Solana’s Memecoin Fallout, and HyperEVM | Analyst Round Table

0xResearch

Crypto
DeFi

Key Takeaways:

  • 1. Institutional Momentum: Bitcoin’s increasing adoption by institutional investors solidifies its position as a stable digital asset, offering a counterbalance to market volatility.
  • 2. Solana’s Resilience: Despite challenges from memecoin fallout, Solana’s strong ecosystem and fundamental value propositions continue to sustain its growth and developer interest.
  • 3. HyperEVM’s Potential: The rise of HyperEVM highlights the ongoing innovation in blockchain technology, emphasizing the need for multi-faceted DeFi solutions to compete with established platforms like Solana.
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