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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

February 7, 2026

Do We Still Need L2s Now That Ethereum Has Scaled? - Uneasy Money

Unchained

Crypto
Key Takeaways:
  1. Ethereum's L1 scaling redefines L2s from pure throughput solutions to specialized platforms, while AI agents introduce a new, autonomous layer of on-chain activity.
  2. Investigate L2s that offer unique features or cater to specific enterprise needs beyond just low fees.
  3. The future of crypto involves a more performant Ethereum L1, specialized L2s, and a burgeoning agentic economy.
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February 8, 2026

Want to Hire an AI Agent? Check Their Reputation Via ERC-8004

Unchained

Crypto
Key Takeaways:
  1. The rapid rise of autonomous AI agents demands a decentralized trust layer. Blockchains, initially an "internet of money," are now becoming the foundational "internet of trusted agent commerce," providing verifiable identity and reputation essential for multi-agent economies. This shift moves beyond simple payments to establishing a credible, censorship-resistant framework for AI-driven interactions.
  2. Integrate ERC-8004 into agent development. Builders should register their AI agents on ERC-8004 to establish verifiable on-chain identity and reputation, attracting trusted interactions and avoiding future centralized platform fees or censorship.
  3. The future of AI commerce hinges on decentralized trust. ERC-8004 is the foundational primitive for this, ensuring that as AI agents become more sophisticated and transact more value, the underlying infrastructure remains open, fair, and resistant to single points of control. This is a critical piece of the puzzle for anyone building or investing in the agent economy over the next 6-12 months.
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February 8, 2026

Hash Rate - Ep.157 - Mining Bittensor with OpenClaw

Hash Rate Podcast

Crypto
Key Takeaways:
  1. Agentic AI is not just a tool; it's a new layer of abstraction for decentralized networks. It shifts the barrier to entry from deep technical and crypto-specific knowledge to strategic prompting and resource allocation, accelerating network participation and value accrual.
  2. Experiment now. Deploy a hosted agentic AI like OpenClaw (via seafloor.bot) with a small budget to understand its capabilities in a controlled environment. Focus on automating complex setup tasks within decentralized AI protocols like Bittensor to gain firsthand experience before others.
  3. The rise of agentic AI agents will fundamentally reshape how individuals and organizations interact with and profit from decentralized AI. Those who master agent orchestration and "skill" development will capture disproportionate value as these systems become the primary interface for programmable intelligence and capital.
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February 7, 2026

Crypto’s Reality Check | Roundup

Bell Curve

Crypto
Key Takeaways:
  1. AI's gravitational pull on talent and capital is forcing crypto to mature beyond speculative tokenomics, transitioning focus from "meme value" to demonstrable product-market fit and real-world utility.
  2. Identify and invest in projects building at the intersection of crypto and AI, or those creating "net new" applications that abstract away crypto complexity for mainstream users, especially in areas like identity or fintech.
  3. This bear market is a necessary, albeit painful, reset. It's a time for builders to focus on creating tangible value and for investors to seek out projects with genuine utility, as the era of easy speculative gains is over.
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February 7, 2026

How Chutes Hit 160B Tokens/Day (Without Centralized Infrastructure)

The Opentensor Foundation | Bittensor TAO

Crypto
Key Takeaways:
  1. The commodification of AI compute, driven by decentralized networks, is shifting power from centralized data centers to globally distributed, incentive-aligned miners. This creates a more efficient, resilient, and cost-effective foundation for intelligence.
  2. Explore building AI agents and applications on Shoots' expanding platform, leveraging their TEEs and end-to-end encryption for privacy-sensitive use cases. The "Sign in with Shoots" OAuth system offers a compelling way to integrate AI capabilities without upfront compute costs.
  3. Shoots is not just an inference provider; it's building the foundational infrastructure for a truly decentralized, private, and intelligent internet. Over the next 6-12 months, expect to see a proliferation of sophisticated AI agents and applications built on Shoots, driven by its unique blend of incentives, security, and global compute.
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February 7, 2026

Vitalik Signals the End of the Rollup-Centric Roadmap: What's Next?

Bankless

Crypto
Key Takeaways:
  1. The Macro Shift: Ethereum pivots from a "rollup-centric" vision to a multi-faceted approach: a powerful, ZKVM-scaled L1 coexists with a diverse "alliance" of specialized L2s. This adapts to technical realities and renews L1's core focus.
  2. The Tactical Edge: Builders should prioritize differentiated L2 solutions or contribute to L1's ZKVM scaling. Investors should evaluate L2s based on distinct utility and symbiotic relationship with Ethereum.
  3. The Bottom Line: Ethereum's market leadership remains, but this pivot signals a pragmatic roadmap. The next 6-12 months will see rallying around L1 ZKVM scaling and clearer L2 roles, demanding sharper focus on where value accrual and innovation occur.
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