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AI Podcasts

May 30, 2025

Hey Tech, Come to Healthcare

a16z

AI
Key Takeaways:
  1. **Build for Behavior Change:** The biggest wins will come from engaging consumers and enabling sustainable health behaviors, an area where tech excels.
  2. **AI is the Leapfrog:** Healthcare can jump directly to AI-driven solutions, bypassing clunky legacy software, especially for service-oriented tasks.
  3. **The Trillion-Dollar Prize is Real:** Whether through full-stack "payvider" models or horizontal platforms, the path to becoming the world's largest company runs through transforming the consumer healthcare experience.
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May 29, 2025

Building a DePIN-powered Shazam for Media with Rumi | Niko Cunningham and Mateusz Poreda

Proof of Coverage Media

AI
Key Takeaways:
  1. **Decentralized Analytics:** Rumi’s DePIN model democratizes media intelligence, offering far richer and more granular data than traditional players like Nielsen.
  2. **Context is King:** The "Shazam for media" capability will fuel a new generation of AI agents and interactive experiences, making media deeply engaging.
  3. **Investor Signal:** The $5M pre-seed (EV3, A16Z CSX) and early traction with industry players like Tivision validate Rumi's approach and market potential.
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May 29, 2025

Beyond Leaderboards: LMArena’s Mission to Make AI Reliable

a16z

AI
Key Takeaways:
  1. Reliability Demands Real-Time, Human-Centric Testing: Static benchmarks are dead. AI reliability for complex tasks requires continuous evaluation based on diverse, subjective human preferences in real-world scenarios.
  2. Crowd-Sourced Evaluation Outperforms Insular Expertise: The "wisdom of the crowd," as captured by LMArena, provides a more robust and representative measure of AI performance than siloed expert opinions, preventing narrow value-encoding.
  3. Personalized Evaluation is the Next Frontier: Technologies like "Prompt to Leaderboard" show the potential for highly granular, cost-effective, and personalized AI model selection, maximizing utility for individual users and specific tasks.
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May 28, 2025

Rick Rubin: Vibe Coding is the Punk Rock of Software

a16z

AI
Key Takeaways:
  1. Embrace AI as a Co-Creator: Leverage AI to democratize creation and rapidly iterate, but remember the unique human element—your distinct point of view and intuition—is irreplaceable.
  2. Authenticity Over Algorithm: Whether you're an artist or an entrepreneur, genuine connection comes from unwavering commitment to your core vision, not by chasing fleeting trends or assumed audience desires.
  3. Question Everything, Especially "Answers": Cultivate a mindset of curiosity and critical thinking. AI can provide answers, but true insight comes from deeply engaging with questions and understanding that knowledge is ever-evolving.
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May 27, 2025

7 More Healthy Years: What We Can Learn from Super Agers

a16z

AI
Key Takeaways:
  1. Embrace AI-Powered Prevention: AI's capacity to synthesize vast health data will redefine personalized risk assessment and early intervention, moving us beyond one-size-fits-all healthcare.
  2. Target the "Big Three" Early: Focus on preventing cancer, cardiovascular disease, and neurodegenerative conditions by leveraging their long incubation periods for proactive interventions.
  3. Leverage New Therapeutic Frontiers: Groundbreaking drug classes like GLP-1s and rapid advancements in immunotherapy offer unprecedented tools to combat and, crucially, prevent major diseases.
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May 27, 2025

TAOFU's Mikel & Mitch: Enabling Capital Formation for Subnets on Bittensors $10B+ Network

Delphi Digital

AI
Key Takeaways:
  1. Democratized Subnet Funding: TAOFU’s SNS model allows subnet creators to raise capital without diluting their core emission-earning potential, fostering more shots on goal for AI innovation on Bittensor.
  2. Investor Access & Liquidity: For investors, TAOFU provides a clear mechanism (SNS tokens and an integrated DEX) to invest in early-stage Bittensor subnets and gain liquidity, previously a closed-off and opaque process.
  3. Curated Quality: TAOFU’s permissioned approach and focus on sustainable value capture (with plans for a curator model) aim to filter for high-quality projects, protecting investors while nurturing promising AI ventures within Bittensor.
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May 26, 2025

Has AI Revived the DePIN Sector? | Dmitriy Berenzon

0xResearch

AI
Key Takeaways:
  1. AI is DePIN's Demand Catalyst: The need for affordable AI compute is breathing new life and tangible demand into decentralized infrastructure.
  2. Value Accrual & Revenue are King: For DePIN tokens to thrive in liquid markets, clear mechanisms for value flow-through from opco revenue to the token are non-negotiable; "ARR is the new TVL."
  3. Distribution Trumps Decentralization (for now): Crypto-native solutions, especially in payments, must crack the distribution code or risk being outmaneuvered by Web2 incumbents leveraging their massive user bases.
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May 26, 2025

Chatbot platforms might replace social media

Machine Learning Street Talk

AI
Key Takeaways:
  1. AI Companionship is Exploding: Millions are already deeply engaged with AI for emotional connection, and this is just the beginning as technology like GPT-4o normalizes it.
  2. Lean Engineering Can Win: Chai's success with a tiny, hyper-talented team and innovative techniques like model blending proves that massive VC-backed operations aren't the only path to scale in AI.
  3. The Next Social Platform Might Be AI: As AI offers more active, personalized, and consequence-free social interaction, it could very well become the dominant way people connect, potentially supplanting traditional social media.
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May 25, 2025

How Endless Debt Became America's Culture

Forward Guidance

AI
Key Takeaways:
  1. **Debt is Destiny:** America's fiscal irresponsibility and cultural embrace of debt ensure ongoing money printing and inflation, making currency debasement a near certainty.
  2. **The One True Trade:** Forget complex analytics; the primary goal is preserving purchasing power. This means owning store-of-value assets like Bitcoin and gold, which are positioned to thrive.
  3. **AI Accelerates the Crisis:** Artificial intelligence will not only disrupt labor markets but also intensify the debt crisis by devaluing traditional education and fueling calls for more government relief.
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Crypto Podcasts

December 2, 2025

Crypto Dumps on BOJ Pivot Signal as Tether, Strategy Turmoil Hit Markets: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Leverage is the Real Trigger. The BOJ pivot was just the spark. The crypto market’s bonfire was fueled by excessive leverage, turning a macro ripple into a tidal wave and signaling a broader rotation from high-beta assets to value.
  2. Narrative Trumps Fundamentals (For Now). MicroStrategy’s CEO stated a basic corporate finance reality—they’d sell BTC if required to service debt—and the market tanked. This proves that in retail-driven markets, violating the "diamond hands" story is more damaging than a weak balance sheet.
  3. TradFi's Glass House. While legacy finance lobbies against crypto’s perceived risks, its own critical infrastructure is failing due to mundane issues like a broken air conditioner, making a powerful, real-time case for decentralized resilience.
See full notes
December 2, 2025

Crypto Dumps on BOJ Pivot Signal as Tether, Strategy Turmoil Hit Markets: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Leverage is the Accelerant: The market's violent reaction to predictable macro news reveals a system still prone to painful, cascading deleveraging events driven by over-leveraged players.
  2. Narratives are Fragile Assets: MicroStrategy’s stumble shows that in crypto, narrative integrity is as critical as financial solvency. A violation can trigger sell-offs regardless of underlying fundamentals.
  3. Old Systems Break While New Ones are Built: The CME outage is a powerful, real-time advertisement for decentralized alternatives, underscoring TradFi's fragility even as its gatekeepers resist change.
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December 2, 2025

Crypto Dumps on BOJ Pivot Signal as Tether, Strategy Turmoil Hit Markets: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. Macro is Back in Charge. The era of cheap leverage is facing a global reckoning, with the unwind of the Yen Carry Trade serving as a key trigger. High-beta assets like crypto are the first to feel the pain.
  2. Narrative Trumps Numbers. MicroStrategy's dip wasn't about math; it was about breaking a story. In crypto, violating a core community belief can be more damaging than a weak earnings report.
  3. TradFi's Fragility is Crypto's Calling Card. While crypto fends off FUD, a major institution like the CME went offline for 10 hours due to a failed air conditioner. This is a powerful, real-world advertisement for decentralized resilience.
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December 2, 2025

Crypto Dumps on BOJ Pivot Signal as Tether, Strategy Turmoil Hit Markets: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. High-Beta is a Crowded Trade: Crypto, alongside assets like uranium and quantum stocks, is being sold off in unison as investors rotate into value stocks. In this defensive environment, expect Bitcoin to outperform altcoins.
  2. Narrative Trumps Fundamentals (For Now): MicroStrategy’s stock plunged not on a fundamental crisis but on the CEO admitting they *might* sell Bitcoin in a corner case—a direct violation of their "never sell" narrative.
  3. Don't Fight the Central Banks: The BOJ’s tightening signal was the trigger for the dump. Conversely, the Fed's expected rate cuts and potential for future dovish leadership remain the key bullish catalysts to watch.
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December 2, 2025

LIVE | CRYPTO TRENDS WITH ALANA FROM VARIANT | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. DEXes Are Winning by Default: The sheer volume of new, on-chain-only tokens is an unstoppable force driving users to DEXes. Centralized exchanges can either integrate or become irrelevant for the long tail of assets.
  2. The Real Money is in the Rails: Don't focus on who will issue the next dominant stablecoin. The biggest opportunity lies in building the interoperability infrastructure that will connect the coming flood of branded, corporate, and national stablecoins.
  3. Bitcoin's Ultimate Bull Case is Geopolitical: In a world of fragmenting currencies and rising geopolitical tensions, Bitcoin's status as a non-sovereign, politically neutral asset makes it the ultimate contender for a global reserve currency.
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December 2, 2025

LIVE | CRYPTO TRENDS WITH ALANA FROM VARIANT | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. **Memecoins Were a Trojan Horse:** The speculative frenzy was a catalyst that massively accelerated DEX adoption and forced millions of users to finally learn how to use self-custody wallets and on-chain tools.
  2. **Prepare for Thousands of Stablecoins:** Every company with deposits will likely issue its own "branded money." The next major infrastructure battle will be building the interoperability layers—the "Visa for stablecoins"—to manage this fragmented liquidity.
  3. **The Real Stablecoin Opportunity is Global:** The next frontier isn't another USD competitor, but non-USD stablecoins tied to high-yield foreign currencies, which will unlock the creation of on-chain foreign exchange (FX) markets.
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