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AI Podcasts

February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The Macro Shift: AI is collapsing the time horizon for technological deployment and market dominance, shifting the competitive advantage from pure innovation to a combination of innovation, capital, and rapid infrastructure deployment.
  2. The Tactical Edge: Invest in companies that are not just building AI, but are fundamentally rethinking existing industries with AI-first principles, recognizing that traditional software moats are eroding.
  3. The Bottom Line: The next 12-24 months will see AI's broad impact kick in, creating unprecedented opportunities for those who understand its new "laws of physics" and the critical role of policy in shaping its trajectory.
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February 4, 2026

Ozempic Won't Solve America's Obesity Problem

a16z

AI
Key Takeaways:
  1. The healthcare system is moving from reactive, acute care to proactive, preventative interventions, driven by the unsustainable costs of chronic disease and a growing understanding of environmental health.
  2. Build infrastructure that financially incentivizes lifestyle interventions, such as TrueMed's HSA/FSA payment rails for health-promoting products and services.
  3. The next decade will see hundreds of billions of dollars redirected towards preventative health. Companies that bridge the gap between lifestyle choices and healthcare financing will capture significant market share.
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February 3, 2026

SpaceX Engineer Explains America's Biggest Energy Mistake | Scott Nolan, CEO of General Matter

The Generalist

AI
Key Takeaways:
  1. The Macro Shift: Global energy demand, driven by AI, forces a strategic re-evaluation of nuclear power. This creates a window for nations to re-shore critical energy infrastructure, moving from reliance on adversaries to domestic, cost-competitive solutions.
  2. The Tactical Edge: Investigate companies addressing foundational supply chain gaps in critical industries like energy. Look for teams with a "first principles" engineering approach and a track record of commercializing hard tech.
  3. The Bottom Line: America's energy independence and its ability to power future technological growth, like AI, hinge on rebuilding domestic nuclear fuel enrichment. This is not just an industrial opportunity; it is a national security imperative.
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February 4, 2026

The Economic Singularity Will Make Today’s Economy Unrecognizable w/ Dr. Alexander Wissner-Gross

Milk Road AI

AI
Key Takeaways:
  1. The Macro Shift: AI-driven hyperdeflation is colliding with the technical reality of autonomous AI agents creating their own crypto-backed economies, threatening a decoupling from human fiat systems.
  2. The Tactical Edge: Investigate and build infrastructure that bridges human and AI economies, focusing on fiat-to-crypto rails that can accommodate agent-driven transactions to prevent a complete split.
  3. The Bottom Line: The next 5-10 years will see an unprecedented economic transformation. Understanding AI's deflationary power and the emerging AI agent economy is critical for navigating a world where traditional economic models may no longer apply.
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February 3, 2026

OpenClaw Makes AI Agents and CPUs Get Real

Semi Doped

AI
Key Takeaways:
  1. The time of practical AI agents is here, moving compute demand beyond pure GPU inference to a significant reliance on CPUs for coordination, data handling, and security.
  2. Evaluate your agent deployment strategy now, prioritizing sandboxed environments (VPS, dedicated local servers) and exploring cost-optimized model routing to manage API expenses.
  3. Prepare for a future where AI agents become integral to workflows, but recognize the hidden infrastructure costs and security implications, particularly the growing importance of CPU capacity and robust access controls.
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February 4, 2026

⚡️ Context graphs: AI’s trillion-dollar opportunity — Jaya Gupta, Ashu Garg, Foundation Capital

Latent Space

AI
Key Takeaways:
  1. The shift from "how" to "why" in AI agent capabilities creates a new, multi-trillion-dollar market for companies that can capture institutional decision logic.
  2. Invest in or build agentic systems that are in the "right path" of business processes, actively capturing decision traces from unstructured data.
  3. Hundreds of context graphs will be in production at scale within a year, defining a new "context graph stack." The winning companies will be those that master this flywheel, extracting value to accelerate automation and build deep, defensible moats.
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February 2, 2026

We Entered an Era Where No One Knows What Comes Next

Turing Post

AI
Key Takeaways:
  1. The shift from linear, bottleneck-driven technological progress to a multi-layered, interconnected advancement model in AI has rendered traditional forecasting obsolete, forcing a re-evaluation of what "singularity" truly represents.
  2. Prioritize adaptability: Invest in modular, composable AI infrastructure and tools that thrive in multi-layered, unpredictable environments, rather than betting on single-bottleneck solutions.
  3. The inability to narrate AI's future means traditional roadmaps are obsolete; success hinges on navigating simultaneous, interconnected advancements and embracing the emergent.
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February 3, 2026

Why The Laws of Startup Physics Have Changed | Ben Horowitz Interview

Invest Like The Best

AI
Key Takeaways:
  1. The era of infrastructure-heavy tech deployment is over; AI's internet-native nature means immediate, widespread application. This shifts the competitive advantage from capital-intensive builds to rapid iteration and data leverage.
  2. Invest in companies that are not just using AI, but are fundamentally rethinking their business models around AI's ability to collapse traditional cost structures and accelerate product development.
  3. AI is a force multiplier for both individual opportunity and national power. Understanding its immediate deployability and the new rules of company building is crucial for investors and builders aiming to lead in the next wave of innovation over the next 12-24 months.
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February 2, 2026

Ben Horowitz and David Solomon: The Sweetest Macro Spot in 40 Years

a16z

AI
Key Takeaways:
  1. Unprecedented fiscal and monetary stimulus, coupled with a deregulatory environment, creates a powerful tailwind for financial assets and tech, driving a capital investment super cycle.
  2. Investors should prioritize companies with proprietary data and GPU access, as these are the new moats in an AI-driven world where traditional software leads are eroding.
  3. The convergence of a stimulative macro environment and AI's disruptive force means capital will flow to those who can scale, innovate, and navigate complex policy landscapes, making strategic positioning now critical for future relevance.
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Crypto Podcasts

January 21, 2026

Quadrillions: How to Win the World | Chris Maurice

Empire

Crypto
Key Takeaways:
  1. The transition from public peer-to-peer narratives to private B2B infrastructure that connects local bonds to global stablecoins.
  2. Build for the back end of the product by integrating with local financial institutions that already own the user relationship.
  3. The next year will see the rise of global dollar-denominated accounts, making the US dollar a truly borderless commodity.
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January 21, 2026

Market Structure, Macro Volatility, and the Next Phase of Crypto | Michael Anderson & Vance Spencer

Bell Curve

Crypto
Key Takeaways:
  1. The transition from L1 wars to on-chain businesses means capital is moving toward protocols with clear revenue-sharing models.
  2. Monitor Bitmine’s ETH accumulation and the launch of Blackwell GPU clusters. Position in protocols that bridge the gap between AI infrastructure financing and stablecoin liquidity.
  3. The next year belongs to the capital assassins who can blend meme-driven distribution with hard-nosed corporate finance.
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January 20, 2026

LIVE: MegaETH, Pump, NYSE | 0xResearch

0xResearch

Crypto
Key Takeaways:
  1. The Macro Migration: Value is moving from base layers to applications that own the end-user relationship. This transition favors integrated platforms over modular protocols.
  2. The Tactical Edge: Monitor platforms that successfully integrate vertical services like Phantom or Pump.fun. These Everything Apps are the most likely candidates for sustainable revenue growth.
  3. The Bottom Line: The next six months will favor teams that prioritize revenue and user stickiness over speculative token launches.
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January 19, 2026

Why Grayscale Sees ATHs Before Q3, With ETH Outperforming: Bits + Bips

Unchained

Crypto
Key Takeaways:
  1. The erosion of central bank independence turns fiscal debt into a marketing campaign for hard-capped digital assets.
  2. Accumulate Ethereum and top-tier smart contract platforms that offer staking yields before the $40 trillion advised wealth pool begins its structural rotation.
  3. The next year will be defined by the transition from speculative retail trading to structural institutional accumulation driven by a global flight from debasing fiat.
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January 16, 2026

Claude Code, Stablecoin Adoption, and 2026 Trends | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. AI-driven productivity is meeting institutional stablecoin adoption to create hyper-efficient financial services.
  2. Integrate AI-assisted coding into every department to maintain a lean headcount.
  3. Success in the next cycle requires the grit to build through the quiet periods and the agility to utilize AI for rapid product iteration.
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January 14, 2026

$250M & $500M M&A talks, Neo finance category update, lots of action in DC ft. Polygon

The Rollup

Crypto
Key Takeaways:
  1. The rotation from metals to equities then crypto is accelerating as fiat debasement becomes the only political option.
  2. Prioritize "exogenous yield" protocols that bridge real-world revenue on-chain to capture non-inflationary returns.
  3. The next 12 months will see crypto move from an isolated casino to the primary infrastructure for the global financial system.
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