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AI Podcasts

November 17, 2025

Hash Rate - Ep 145 - TAO Subnets Templar (3), Basilica (39), Grail (81)

Hash Rate pod - Bittensor $TAO & Subnets

AI
Key Takeaways:
  1. **A New Market is Born:** Templar isn't just cheaper; it enables something that was previously impossible for 99% of the world. Democratizing pre-training means anyone can build a truly custom, sovereign AI.
  2. **Productization is Underway:** Covenant is no longer just a research project. With enterprise sales in motion, the focus is now on revenue. The team has committed that 100% of fees from custom training will be used to buy back its tokens.
  3. **Economics are Being Rewritten:** Basilica’s incentive mechanism is a direct critique of unsustainable models on other compute subnets. Its focus on profitability and positive TAO flow sets a new standard for economic design on Bittensor.
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November 17, 2025

Bryan Johnson: Don’t Die, Beating Entropy, AI Alignment & The Two-Species Future

Bankless

AI
Key Takeaways:
  1. AI Forces a Moral Reboot. The emergence of superintelligence renders our current societal goals dangerously obsolete. Survival must become the new prime directive.
  2. Existence is a Team Sport. The "Don't Die" philosophy is a collective mission ("we don't die") to ensure species-wide survival, not a selfish quest for individual immortality.
  3. Prepare for the Biological Sandbox. Humanity is moving from manipulating physical atoms and digital bits to programming our own biology—a frontier with both unimaginable potential and catastrophic risk.
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November 17, 2025

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

a16z

AI
Key Takeaways:
  1. Stop Trying to “Steer” AGI. The control paradigm is a dead end. The goal isn’t a more obedient tool; it’s a trustworthy teammate. We must shift from engineering control to cultivating care.
  2. Alignment is a Process, Not a Product. True alignment isn't a fixed set of rules. It’s a dynamic process of moral learning, akin to raising a child. AIs that only follow rules are brittle and dangerous.
  3. Build for Cooperation, Not Command. The technical path forward involves training AIs in rich, multi-agent environments where they must learn cooperation and theory of mind—the foundational skills for becoming a good member of a group.
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November 16, 2025

Rawson Haverty presents "US & China AI: Lessons from Across the Pacific" | dAGI Summit 2025

Delphi Digital

AI
Key Takeaways:
  1. US Leads in Capital-Intensive Frontier AI; China Excels at Industrial Diffusion. The US leverages deep capital markets for its massive compute buildout and AGI research, while China uses state direction to embed AI into its vast industrial base via open-source models and hardware.
  2. Market Structure Dictates AI Strategy. The US "efficient oligopoly" model prioritizes global dominance and profit reinvestment by a few players. China's "subjugated swarm" model creates intense domestic competition, driving down prices and accelerating adoption at the cost of profitability.
  3. Geopolitical Tension May Be a Necessary Stabilizer. The competition between the US's freedom-oriented, frontier-pushing approach and China's stability-focused, diffusion-driven model creates a complementary tension that could be essential for navigating the "narrow corridor" between AI-driven totalitarianism and uncontrollable chaos.
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November 13, 2025

How Will AI Change Gaming Development? (A Dev’s Take)

The DCo Podcast

AI
Key Takeaways:
  1. Development timelines are collapsing from months to days. AI allows developers to swap entire asset libraries or generate new game concepts at unprecedented speed, turning a two-month art project into a day's work.
  2. The lifespan of any single game is shrinking. Prepare for a world of disposable entertainment. As AI floods the market with content, the strategy will pivot from creating one long-lasting hit to deploying a rapid succession of engaging experiences.
  3. Games are the next evolution of the attention economy. Just as memes became a core tool for community-building around tokens, easily created games will be the next engine for capturing and directing user attention in a hyper-competitive digital world.
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November 11, 2025

AI Nerves, Crypto Realism, Privacy Coins, & Lessons From Trading

1000x Podcast

AI
Key Takeaways:
  1. Adopt a Stock Picker's Mentality. The crypto market is no longer a monolith where a rising tide lifts all boats. Focus on assets with real products, user growth, and cash flow, as the gap between winners and losers will only widen.
  2. Shorting is a Tactical Assault, Not a Siege. Don't "invest" in a short. The only viable short strategies are tactical, targeting specific events like VC unlocks or news-driven spikes. Otherwise, even "total scams" can 5x against you.
  3. Cultivate a Goldfish's Memory. The most critical trading skill is learning how to change your mind. Cut losing trades, forget the loss (but remember the lesson), and redeploy capital without emotional baggage. Stubbornness is a portfolio killer.
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November 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

a16z

AI
Key Takeaways:
  1. Word-of-mouth isn't a feature; it's the engine. Before spending a dime on marketing, obsess over the first 30 seconds of the user experience until people can't help but share it.
  2. Being different is better than being better. Don't build incrementally better slideware. Redefine the core primitives of your category, as Gamma did by moving beyond the 16x9 slide.
  3. Hire painfully slowly to protect your DNA. Resisting the temptation to scale headcount with user growth is a superpower. The goal isn't to hit a hiring target; it's to hire the best people.
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November 7, 2025

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

a16z

AI
Key Takeaways:
  1. AGI Is a Definitional Debate. Progress toward an AI that can replace a remote worker is happening fast. However, achieving "true" human-like learning efficiency may require an entirely new paradigm beyond scaling current LLMs.
  2. The New Creator Economy Is Code. AI is turning software development into a mainstream creative pursuit, empowering a new class of solo entrepreneurs who can build what previously required entire teams.
  3. Incumbents Learned Their Lesson. Unlike past tech shifts, today's giants are aggressively adopting AI, making it both a sustaining *and* disruptive force. The market is large enough for both incumbents and startups to create massive value.
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November 6, 2025

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

a16z

AI
Key Takeaways:
  1. Build the Tools, Not Just the House: CZI’s greatest leverage comes from creating open-source tools and datasets. By building the fundamental infrastructure, they empower the entire scientific community—from academic labs to startups—to accelerate discovery.
  2. Data Is the New Microscope: The future of biology hinges on a tight feedback loop between generating novel, purpose-built datasets and training domain-specific AI models on them. This synergy is unlocking insights that were previously impossible.
  3. Virtual Biology Is the Next Frontier: Simulating biology computationally with "virtual cells" will become the new standard for research, enabling scientists to test riskier hypotheses faster and cheaper, dramatically compressing the timeline for major breakthroughs.
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Crypto Podcasts

February 10, 2026

2 Million TPS and Decentralized? Has the Zero Blockchain Cracked Scalability?

Unchained

Crypto
Key Takeaways:
  1. Institutional capital is increasingly seeking permissionless, global markets, but existing blockchain infrastructure struggles to meet this demand without compromising core decentralized values. Zero attempts to bridge this gap by delivering enterprise-grade throughput on a broadly decentralized network.
  2. Evaluate Zero's technical papers (QMDB, FAFO, Zero OS) and upcoming mainnet launch. Builders should consider its multi-VM and Linux binary compatibility for deploying high-performance applications, especially in payments and global markets.
  3. Zero represents a bold attempt to solve the blockchain scalability trilemma through fundamental architectural breakthroughs and strategic institutional partnerships. Its success could redefine what's possible for decentralized finance and global markets over the next 6-12 months, making it a critical project to monitor.
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February 11, 2026

Crypto’s Legal Lines, MegaETH Launched But Delayed TGE, and LayerZero's Bombshell

Unchained

Crypto
Key Takeaways:
  1. The industry is moving from a "build it and they will come" mentality to a highly intentional, ecosystem-first approach, recognizing that raw tech specs alone don't guarantee adoption. This is coupled with a critical legal battle to define developer liability, which will dictate the future of open-source crypto innovation.
  2. Investigate projects that prioritize real-world utility and long-term ecosystem health over short-term token hype. For builders, focus on creating "10x" user experiences that justify new infrastructure, while understanding the evolving legal framework for non-custodial software.
  3. The next 6-12 months will see a clearer delineation of regulatory boundaries for developers and a competitive race among high-performance chains to onboard institutional and consumer applications. Success hinges on a blend of technical superiority, strategic ecosystem cultivation, and legal clarity.
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February 11, 2026

How I Called 2026's Biggest Rally | Vincent Delaurd

Forward Guidance

Crypto
Key Takeaways:
  1. The US economy undergoes a "Great Reset" towards higher nominal growth, rates, and deficits, underpinned by surging gig economy tax collections and unprecedented AI capital expenditure, creating a disconnect with conventional sentiment.
  2. Overweight international assets, particularly Latin America and Europe, to diversify from over-concentrated US equity.
  3. The confluence of hidden nominal growth, aggressive fiscal policy, and AI-driven capex points to a sustained inflationary environment and asset price appreciation through 2026, challenging recessionary fears and demanding a re-evaluation of portfolio allocations.
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February 10, 2026

This Is the Layer Making RWAs Finally Interoperable

The DCo Podcast

Crypto
Key Takeaways:
  1. The DeFi era is consolidating. Institutional RWA adoption will drive isolated, high-volume activity on private chains. LeiFi builds the connective tissue to bridge these environments.
  2. Builders and investors should prioritize infrastructure that abstracts multi-chain complexity and provides robust distribution for tokenized assets. Investigate LeiFi's new checkout product and intent system.
  3. Exponential fragmentation is crypto's reality for the next decade. LeiFi's meta-aggregation, virtual machine, and intent system are foundational rails for institutional capital and RWA liquidity.
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February 10, 2026

This Lesser Known Type of Stablecoin Is Better Than USDC & USDT - Michael Svoboda

The Rollup

Crypto
Key Takeaways:
  1. Diversify stablecoin holdings beyond regulated fiat-backed options. Allocate a portion to decentralized, crypto-backed stablecoins to gain uncorrelated yield, mitigate counterparty risk, and preserve property rights, especially for crypto-native operations or users in restrictive jurisdictions.
  2. The increasing weaponization of traditional finance and demand for censorship resistance is driving a technical reality: the need for truly sovereign, code-governed financial primitives. This pushes capital towards crypto-native stablecoins that offer an opt-out from traditional financial control.
  3. Regulated stablecoins will become commoditized rails for traditional finance, while truly decentralized stablecoins will solidify their niche as the preferred choice for those prioritizing censorship resistance, self-custody, and organic DeFi yield. Understanding this bifurcation is crucial for positioning portfolios and building infrastructure that aligns with crypto's core ethos.
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February 9, 2026

Seby Rubino: Mortgages You NEVER Repay? Resi Labs, AI Real Estate Appraisals, Tokenized Assets | 80

Ventura Labs

Crypto
Key Takeaways:
  1. The real estate industry is undergoing a fundamental re-architecture, moving from centralized, opaque, and debt-heavy models to decentralized, transparent, and equity-driven tokenized platforms. This shift, powered by AI and blockchain, will redefine property access and wealth creation.
  2. Investigate tokenization platforms that leverage AI for appraisal and inspection, particularly those offering yield-bearing real estate tokens. Consider strategies that use rental income to service interest on borrowed capital, effectively creating leveraged exposure to appreciating assets without traditional mortgage obligations.
  3. The convergence of AI and tokenization is not just optimizing real estate; it is creating entirely new financial primitives. Understanding Resi's full-stack approach—intelligence, infrastructure, and financial services—is crucial for positioning yourself in a market that could soon offer "mortgages you don't pay back" and unlock unprecedented liquidity for property owners.
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