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AI Podcasts

December 18, 2025

SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)

Latent Space

AI
Key Takeaways:
  1. Vision AI Democratization: SAM 3 lowers the barrier for sophisticated vision tasks, making advanced segmentation and tracking accessible for a wider range of applications.
  2. Builder/Investor Note: Focus on domain-specific adaptations and tooling that enhance human-AI interaction for ambiguous visual concepts. The "last mile" of user intent is a key differentiator.
  3. The "So What?": SAM 3 accelerates the development of multimodal AI, particularly in robotics and video analysis, by providing a robust, scalable visual foundation for the next generation of intelligent systems.
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December 18, 2025

How to build an AI native company (even if your company is 50 years old) – Dan Shipper, Every

AI Engineer

AI
Key Takeaways:
  1. The 100% AI adoption threshold is a step-function change, not incremental. Companies that commit fully will outpace those with partial integration.
  2. Builders should prioritize "compounding engineering" by codifying knowledge into reusable prompts. This builds an organizational memory that accelerates future development exponentially.
  3. Re-evaluate team structures and roles. Single engineers can own complex products, and even technical managers can contribute code, shifting how organizations operate.
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December 18, 2025

AI Consulting in Practice – NLW, Super ai

AI Engineer

AI
Key Takeaways:
  1. The Agent Economy is Here: Enterprises are moving past pilots with AI agents. Builders should focus on orchestration layers and human-agent interaction design.
  2. ROI Measurement is the Next Frontier: Investors should look for solutions that help organizations accurately track and attribute AI value beyond traditional metrics.
  3. Strategic AI, Not Spot Solutions: The biggest wins come from systematic, cross-organizational AI strategies that target new capabilities and revenue growth, not just incremental time savings.
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December 18, 2025

The EU and the not-so-simple macroeconomics of AI – Luis Garicano

Epoch AI

AI
Key Takeaways:
  1. Strategic Implication: The global AI race is a zero-sum game for foundational models. Europe's best strategy is a "smart second mover" approach, focusing on the implementation layer by ensuring interoperability and data portability.
  2. Builder/Investor Note: Invest in AI that achieves true autonomy and enhances expert productivity. Be wary of markets stifled by over-regulation, which can impede AI adoption and growth.
  3. The "So What?": Europe faces a critical juncture. Without embracing AI-driven growth, its demographic and debt problems will worsen, leading to higher interest rates without the corresponding economic expansion.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade will be defined by who builds the core infrastructure for intelligence. This is where the most significant value and influence will accrue.
  2. Builder/Investor Note: Direct capital and talent towards foundational AI components—chips, models, and interoperable systems. Avoid the temptation to only build at the application layer.
  3. The So What?: The window for shaping the future of intelligence is now. Engage in the deepest, most complex challenges to secure a footprint in this new era.
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December 18, 2025

Two Futures | Runtime 2025

a16z

AI
Key Takeaways:
  1. Strategic Implication: The next decade's value will accrue to those building foundational AI infrastructure and the "invisible layers" that connect intelligent systems.
  2. Builder/Investor Note: Focus capital and talent on core AI models, specialized domain intelligence, and the underlying computational fabric. Superficial applications risk rapid commoditization.
  3. The So What?: This is the defining period for the architecture of global intelligence. Participation now determines future influence and relevance.
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December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Strategic Implication: The next frontier in AI is agentic, and progress hinges on fundamental pre-training innovation, not just post-training optimizations.
  2. Builder/Investor Note: Focus on teams with deep experience in scaling and debugging large models, as this is a high-capital, high-risk endeavor. Builders should prioritize developing new benchmarks for agentic capabilities.
  3. The "So What?": The industry needs to move beyond next-token prediction and static benchmarks to unlock truly capable, self-correcting AI agents in the next 6-12 months.
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December 17, 2025

Rethinking Pre-Training for Agentic AI [Aakanksha Chowdhery] - 759

The TWIML AI Podcast with Sam Charrington

AI
Key Takeaways:
  1. Pre-Training is the New Frontier: The next leap in AI capabilities, particularly for agentic systems, will come from fundamental advancements in pre-training, not just post-training tweaks.
  2. Builders & Investors: Focus on teams rethinking loss objectives, curating high-quality reasoning data, and developing dynamic benchmarks for agentic capabilities. Be wary of "agentic" claims that lack foundational pre-training innovation.
  3. The "So What?": Over the next 6-12 months, expect a push for new benchmarks and data strategies that explicitly train models for multi-step planning, long-form reasoning, and error recovery, moving beyond simple next-token prediction.
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December 17, 2025

Code World Model: Building World Models for Computation – Jacob Kahn, FAIR Meta

AI Engineer

AI
Key Takeaways:
  1. Shift in AI Development: The focus moves from syntax-aware code generation to execution-aware reasoning, enabling more robust and intelligent code agents.
  2. Builder/Investor Note: Prioritize tools and platforms that support explicit execution modeling and highly asynchronous, high-throughput RL training for agentic systems.
  3. The "So What?": AI that can simulate complex systems internally will drastically reduce development and testing costs, accelerating innovation in software and distributed systems over the next 6-12 months.
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Crypto Podcasts

November 29, 2025

In Defense of Exponentials – Haseeb Reads His Viral Essay – The Chopping Block

Unchained

Crypto
Key Takeaways:
  1. **Stop Applying Linear Valuations to Exponential Tech.** Judging Ethereum on its P/E ratio is like criticizing Amazon in 1999 for its lack of profits. It’s a category error. Value chains based on their probability of capturing a piece of a future trillion-dollar system.
  2. **The Prize Is Worth Winning.** The entire investment case for new L1s hinges on the belief that incumbents like Ethereum and Solana are immensely valuable. If they are, then a small probability of becoming the next one justifies a multi-billion dollar valuation today.
  3. **Zoom Out and Believe.** The current market is trapped in short-term cynicism. The real alpha comes from adopting a Silicon Valley mindset over a Wall Street one, recognizing that you are living through a technological revolution on par with the early internet.
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November 28, 2025

Can ‘Choose Rich’ Nick Create the Barstool Sports of Crypto?

Unchained

Crypto
Key Takeaways:
  1. Weaponize cringe for distribution. The ‘Choose Rich Nick’ model proves that being the butt of the joke is a powerful growth hack. Manufacturing moments that invite mockery creates a viral loop of outrage and engagement that funnels attention to the core business.
  2. Authenticity is a liability. The most successful stunts are meticulously planned fabrications. From fake girlfriends to staged yacht expulsions, the goal isn't to be real but to create a compelling narrative that the internet can’t ignore.
  3. Success hinges on ambiguity. The content is designed to polarize. Its virality depends on a split audience: one half gets the joke and celebrates the performance, while the other half takes it at face value, fueling the outrage machine that drives impressions.
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November 28, 2025

Klarna Launches A Stablecoin, Hyperliquid Perps & The Prediction Market Wars | Weekly Roundup

Empire

Crypto
Key Takeaways:
  1. Fintech is the New On-Ramp. Giants like Klarna are adopting stablecoins for economic utility, not speculation. This signals a new wave of adoption driven by real-world efficiency gains.
  2. Re-evaluate Your Valuations. The massive valuation gap between a fintech like Klarna and an L1 like Solana forces a critical question: will value accrue to the rails or the businesses that use them to serve hundreds of millions of customers?
  3. Distribution is Undefeated. Robinhood’s move to sideline its partner Kalshi proves that owning the customer relationship is the ultimate moat, a crucial lesson for infrastructure projects reliant on third-party distribution.
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November 27, 2025

Anthony Sassano on Why This Cycle Isn’t Playing Out Like the Last Ones

Bankless

Crypto
Key Takeaways:
  1. The Old Playbooks Are Obsolete. This isn't your 2021 bull run. The four-year cycle is broken, institutional flows have altered market dynamics, and historical patterns are no longer reliable predictors of future performance.
  2. Ethereum Is Entering Hyper-Scale. A relentless upgrade cadence is simultaneously scaling both L1 (via gas limit increases) and L2s (via blob scaling), even before the ZK revolution delivers another 100x+ throughput boost to the mainnet.
  3. Adaptability Is the Ultimate Security. Existential threats like quantum computing are moving from science fiction to near-term reality. Ethereum's culture of continuous improvement is its greatest defense, while chains resistant to change face a brewing crisis.
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November 25, 2025

Closed my ETH Short ($578k Profit). What’s Next for Crypto?

Taiki Maeda

Crypto
Key Takeaways:
  1. **ETH is Overvalued and Avoidable.** Its fundamentals do not justify its sky-high valuation. View it as a flawed asset, not a mandatory portfolio holding for crypto investors.
  2. **Farm, Don't Trade.** The most reliable retail edge isn't trading, but airdrop farming. It allows you to acquire assets from overvalued launches without providing exit liquidity.
  3. **Cash is a Position.** In a market defined by negative reflexivity and dwindling liquidity, the winning strategy is capital preservation. Avoid the casino, raise cash, and wait for the market to present clear, undervalued opportunities.
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November 24, 2025

How to Trade Crypto Cycles with Raoul Pal

Empire

Crypto
Key Takeaways:
  1. Stop Obsessing Over the Halving. The four-year cycle is a narrative, not a driver. The real signal is the macro business cycle, driven by debt refinancing and central bank liquidity. Track the ISM index: historically, buying below 50 and selling above 57 has been a winning strategy.
  2. Invest in Networks, Not Spreadsheets. Value crypto protocols based on network effects (active users and transaction value), not discounted cash flows. The long-term bet is on the growth of the network itself, as this is where wealth has compounded most dramatically.
  3. Survive to Compound. Structure your portfolio to withstand volatility. Have external cash flow so you’re never a forced seller, and take "lifestyle chips" off the table during rallies to manage psychological stress. Drawdowns are a feature, not a bug—use them to add to your long-term positions.
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